{
  "url": "https://dantelabs.com/traits/fatigable-weakness",
  "trait": {
    "bundleId": "2026.10.18-8b139e39",
    "release": "2026-09-01",
    "slug": "fatigable-weakness",
    "id": "HP:0003473",
    "name": "Fatigable weakness",
    "definition": "A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.",
    "synonyms": [
      "Fatigable weakness of limb muscles",
      "Generalised muscle weakness due to defect at the neuromuscular junction",
      "Generalized muscle weakness due to defect at the neuromuscular junction",
      "Myasthenia",
      "Myasthenic weakness",
      "Proximal muscle weakness due to defect at the neuromuscular junction"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-synaptic-transmission-at-the-neuromuscular-junction",
        "name": "Abnormal synaptic transmission at the neuromuscular junction",
        "url": "https://dantelabs.com/traits/abnormal-synaptic-transmission-at-the-neuromuscular-junction"
      },
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      }
    ],
    "narrower": [
      {
        "slug": "fatigable-weakness-of-bulbar-muscles",
        "name": "Fatigable weakness of bulbar muscles",
        "genes": 52,
        "url": "https://dantelabs.com/traits/fatigable-weakness-of-bulbar-muscles"
      },
      {
        "slug": "fatigable-weakness-of-respiratory-muscles",
        "name": "Fatigable weakness of respiratory muscles",
        "genes": 44,
        "url": "https://dantelabs.com/traits/fatigable-weakness-of-respiratory-muscles"
      },
      {
        "slug": "fatigable-weakness-of-skeletal-muscles",
        "name": "Fatigable weakness of skeletal muscles",
        "genes": 9,
        "url": "https://dantelabs.com/traits/fatigable-weakness-of-skeletal-muscles"
      }
    ],
    "genes": [
      {
        "slug": "alg14",
        "symbol": "ALG14",
        "hgnc": "HGNC:28287",
        "name": "ALG14 UDP-N-acetylglucosaminyltransferase subunit",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alg14"
      },
      {
        "slug": "alg2",
        "symbol": "ALG2",
        "hgnc": "HGNC:23159",
        "name": "ALG2 alpha-1,3/1,6-mannosyltransferase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alg2"
      },
      {
        "slug": "chat",
        "symbol": "CHAT",
        "hgnc": "HGNC:1912",
        "name": "choline O-acetyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chat"
      },
      {
        "slug": "chrna1",
        "symbol": "CHRNA1",
        "hgnc": "HGNC:1955",
        "name": "cholinergic receptor nicotinic alpha 1 subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrna1"
      },
      {
        "slug": "chrnb1",
        "symbol": "CHRNB1",
        "hgnc": "HGNC:1961",
        "name": "cholinergic receptor nicotinic beta 1 subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrnb1"
      },
      {
        "slug": "chrnd",
        "symbol": "CHRND",
        "hgnc": "HGNC:1965",
        "name": "cholinergic receptor nicotinic delta subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrnd"
      },
      {
        "slug": "chrne",
        "symbol": "CHRNE",
        "hgnc": "HGNC:1966",
        "name": "cholinergic receptor nicotinic epsilon subunit",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chrne"
      },
      {
        "slug": "colq",
        "symbol": "COLQ",
        "hgnc": "HGNC:2226",
        "name": "collagen like tail subunit of asymmetric acetylcholinesterase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/colq"
      },
      {
        "slug": "gfpt1",
        "symbol": "GFPT1",
        "hgnc": "HGNC:4241",
        "name": "glutamine--fructose-6-phosphate transaminase 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gfpt1"
      },
      {
        "slug": "musk",
        "symbol": "MUSK",
        "hgnc": "HGNC:7525",
        "name": "muscle associated receptor tyrosine kinase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/musk"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn4a"
      },
      {
        "slug": "slc25a1",
        "symbol": "SLC25A1",
        "hgnc": "HGNC:10979",
        "name": "solute carrier family 25 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a1"
      },
      {
        "slug": "snap25",
        "symbol": "SNAP25",
        "hgnc": "HGNC:11132",
        "name": "synaptosome associated protein 25",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snap25"
      },
      {
        "slug": "casq1",
        "symbol": "CASQ1",
        "hgnc": "HGNC:1512",
        "name": "calsequestrin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casq1"
      },
      {
        "slug": "casr",
        "symbol": "CASR",
        "hgnc": "HGNC:1514",
        "name": "calcium sensing receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casr"
      },
      {
        "slug": "gna11",
        "symbol": "GNA11",
        "hgnc": "HGNC:4379",
        "name": "G protein subunit alpha 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gna11"
      },
      {
        "slug": "orai1",
        "symbol": "ORAI1",
        "hgnc": "HGNC:25896",
        "name": "ORAI calcium release-activated calcium modulator 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/orai1"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "stim1",
        "symbol": "STIM1",
        "hgnc": "HGNC:11386",
        "name": "stromal interaction molecule 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stim1"
      },
      {
        "slug": "acad9",
        "symbol": "ACAD9",
        "hgnc": "HGNC:21497",
        "name": "acyl-CoA dehydrogenase family member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acad9"
      },
      {
        "slug": "acadm",
        "symbol": "ACADM",
        "hgnc": "HGNC:89",
        "name": "acyl-CoA dehydrogenase medium chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acadm"
      },
      {
        "slug": "dpagt1",
        "symbol": "DPAGT1",
        "hgnc": "HGNC:2995",
        "name": "dolichyl-phosphate N-acetylglucosaminephosphotransferase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dpagt1"
      },
      {
        "slug": "gmppb",
        "symbol": "GMPPB",
        "hgnc": "HGNC:22932",
        "name": "GDP-mannose pyrophosphorylase B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gmppb"
      },
      {
        "slug": "slc5a7",
        "symbol": "SLC5A7",
        "hgnc": "HGNC:14025",
        "name": "solute carrier family 5 member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a7"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "slc34a2",
        "symbol": "SLC34A2",
        "hgnc": "HGNC:11020",
        "name": "solute carrier family 34 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a2"
      },
      {
        "slug": "dok7",
        "symbol": "DOK7",
        "hgnc": "HGNC:26594",
        "name": "docking protein 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dok7"
      }
    ]
  }
}