{
  "url": "https://dantelabs.com/traits/chronic-bronchitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "chronic-bronchitis",
    "id": "HP:0004469",
    "name": "Chronic bronchitis",
    "definition": "Chronic inflammation of the bronchi.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "bronchitis",
        "name": "Bronchitis",
        "url": "https://dantelabs.com/traits/bronchitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ccdc39",
        "symbol": "CCDC39",
        "hgnc": "HGNC:25244",
        "name": "coiled-coil domain 39 molecular ruler complex subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc39"
      },
      {
        "slug": "ccdc40",
        "symbol": "CCDC40",
        "hgnc": "HGNC:26090",
        "name": "coiled-coil domain 40 molecular ruler complex subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc40"
      },
      {
        "slug": "dnah7",
        "symbol": "DNAH7",
        "hgnc": "HGNC:18661",
        "name": "dynein axonemal heavy chain 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah7"
      },
      {
        "slug": "hydin",
        "symbol": "HYDIN",
        "hgnc": "HGNC:19368",
        "name": "HYDIN axonemal central pair apparatus protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hydin"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "pold1",
        "symbol": "POLD1",
        "hgnc": "HGNC:9175",
        "name": "DNA polymerase delta 1, catalytic subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pold1"
      },
      {
        "slug": "rac2",
        "symbol": "RAC2",
        "hgnc": "HGNC:9802",
        "name": "Rac family small GTPase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rac2"
      },
      {
        "slug": "tap2",
        "symbol": "TAP2",
        "hgnc": "HGNC:44",
        "name": "transporter 2, ATP binding cassette subfamily B member",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tap2"
      },
      {
        "slug": "ubap2l",
        "symbol": "UBAP2L",
        "hgnc": "HGNC:29877",
        "name": "ubiquitin associated protein 2 like",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubap2l"
      },
      {
        "slug": "dnaaf11",
        "symbol": "DNAAF11",
        "hgnc": "HGNC:16725",
        "name": "dynein axonemal assembly factor 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf11"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "dnaaf5",
        "symbol": "DNAAF5",
        "hgnc": "HGNC:26013",
        "name": "dynein axonemal assembly factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf5"
      },
      {
        "slug": "odad2",
        "symbol": "ODAD2",
        "hgnc": "HGNC:25583",
        "name": "outer dynein arm docking complex subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad2"
      },
      {
        "slug": "carmil2",
        "symbol": "CARMIL2",
        "hgnc": "HGNC:27089",
        "name": "capping protein regulator and myosin 1 linker 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/carmil2"
      },
      {
        "slug": "dnaaf4",
        "symbol": "DNAAF4",
        "hgnc": "HGNC:21493",
        "name": "dynein axonemal assembly factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf4"
      },
      {
        "slug": "gusb",
        "symbol": "GUSB",
        "hgnc": "HGNC:4696",
        "name": "glucuronidase beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gusb"
      },
      {
        "slug": "ift54",
        "symbol": "IFT54",
        "hgnc": "HGNC:17861",
        "name": "intraflagellar transport 54",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift54"
      },
      {
        "slug": "odad3",
        "symbol": "ODAD3",
        "hgnc": "HGNC:28303",
        "name": "outer dynein arm docking complex subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad3"
      },
      {
        "slug": "rsph4a",
        "symbol": "RSPH4A",
        "hgnc": "HGNC:21558",
        "name": "radial spoke head component 4A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph4a"
      },
      {
        "slug": "serpina1",
        "symbol": "SERPINA1",
        "hgnc": "HGNC:8941",
        "name": "serpin family A member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpina1"
      },
      {
        "slug": "cfap298",
        "symbol": "CFAP298",
        "hgnc": "HGNC:1301",
        "name": "cilia and flagella associated protein 298",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap298"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "dnmt3b",
        "symbol": "DNMT3B",
        "hgnc": "HGNC:2979",
        "name": "DNA methyltransferase 3 beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3b"
      },
      {
        "slug": "drc2",
        "symbol": "DRC2",
        "hgnc": "HGNC:29937",
        "name": "dynein regulatory complex subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc2"
      },
      {
        "slug": "scnn1a",
        "symbol": "SCNN1A",
        "hgnc": "HGNC:10599",
        "name": "sodium channel epithelial 1 subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1a"
      },
      {
        "slug": "scnn1b",
        "symbol": "SCNN1B",
        "hgnc": "HGNC:10600",
        "name": "sodium channel epithelial 1 subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1b"
      },
      {
        "slug": "scnn1g",
        "symbol": "SCNN1G",
        "hgnc": "HGNC:10602",
        "name": "sodium channel epithelial 1 subunit gamma",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scnn1g"
      },
      {
        "slug": "spag1",
        "symbol": "SPAG1",
        "hgnc": "HGNC:11212",
        "name": "sperm associated antigen 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spag1"
      },
      {
        "slug": "zbtb24",
        "symbol": "ZBTB24",
        "hgnc": "HGNC:21143",
        "name": "zinc finger and BTB domain containing 24",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb24"
      },
      {
        "slug": "zmynd10",
        "symbol": "ZMYND10",
        "hgnc": "HGNC:19412",
        "name": "zinc finger MYND-type containing 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmynd10"
      }
    ]
  }
}