{
  "url": "https://dantelabs.com/traits/bcgosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "bcgosis",
    "id": "HP:0020087",
    "name": "BCGosis",
    "definition": "Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.",
    "synonyms": [
      "BCGiosis",
      "Disseminated Bacillus Calmette-Guerin infection"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "bcg-associated-disease",
        "name": "BCG-associated disease",
        "url": "https://dantelabs.com/traits/bcg-associated-disease"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "map3k14",
        "symbol": "MAP3K14",
        "hgnc": "HGNC:6853",
        "name": "mitogen-activated protein kinase kinase kinase 14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k14"
      },
      {
        "slug": "rel",
        "symbol": "REL",
        "hgnc": "HGNC:9954",
        "name": "REL proto-oncogene, NF-kB subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rel"
      },
      {
        "slug": "tbx21",
        "symbol": "TBX21",
        "hgnc": "HGNC:11599",
        "name": "T-box transcription factor 21",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx21"
      },
      {
        "slug": "cybb",
        "symbol": "CYBB",
        "hgnc": "HGNC:2578",
        "name": "cytochrome b-245 beta chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybb"
      },
      {
        "slug": "il12rb1",
        "symbol": "IL12RB1",
        "hgnc": "HGNC:5971",
        "name": "interleukin 12 receptor subunit beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12rb1"
      },
      {
        "slug": "mcts1",
        "symbol": "MCTS1",
        "hgnc": "HGNC:23357",
        "name": "MCTS1 re-initiation and release factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcts1"
      },
      {
        "slug": "rorc",
        "symbol": "RORC",
        "hgnc": "HGNC:10260",
        "name": "RAR related orphan receptor C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rorc"
      },
      {
        "slug": "ifng",
        "symbol": "IFNG",
        "hgnc": "HGNC:5438",
        "name": "interferon gamma",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifng"
      },
      {
        "slug": "irf1",
        "symbol": "IRF1",
        "hgnc": "HGNC:6116",
        "name": "interferon regulatory factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf1"
      },
      {
        "slug": "znfx1",
        "symbol": "ZNFX1",
        "hgnc": "HGNC:29271",
        "name": "zinc finger NFX1-type containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znfx1"
      }
    ]
  }
}