{
  "url": "https://dantelabs.com/traits/abnormal-retinal-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-retinal-morphology",
    "id": "HP:0000479",
    "name": "Retina issue",
    "label": "Abnormal retinal morphology",
    "definition": "A structural abnormality of the retina.",
    "synonyms": [
      "Abnormal retina",
      "Abnormality of the retina",
      "Anomaly of the retina"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-fundus-morphology",
        "name": "Abnormal fundus morphology",
        "url": "https://dantelabs.com/traits/abnormal-fundus-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-retinal-pigmentation",
        "name": "Abnormal retinal pigmentation",
        "genes": 236,
        "url": "https://dantelabs.com/traits/abnormal-retinal-pigmentation"
      },
      {
        "slug": "retinal-degeneration",
        "name": "Retina degeneration",
        "genes": 225,
        "url": "https://dantelabs.com/traits/retinal-degeneration"
      },
      {
        "slug": "retinopathy",
        "name": "Noninflammatory retina disease",
        "genes": 142,
        "url": "https://dantelabs.com/traits/retinopathy"
      },
      {
        "slug": "retinal-dystrophy",
        "name": "Breakdown of light-sensitive cells in back of eye",
        "genes": 127,
        "url": "https://dantelabs.com/traits/retinal-dystrophy"
      },
      {
        "slug": "abnormal-retinal-vascular-morphology",
        "name": "Abnormality of retina blood vessels",
        "genes": 113,
        "url": "https://dantelabs.com/traits/abnormal-retinal-vascular-morphology"
      },
      {
        "slug": "retinal-detachment",
        "name": "Retinal detachment",
        "genes": 110,
        "url": "https://dantelabs.com/traits/retinal-detachment"
      },
      {
        "slug": "abnormal-chorioretinal-morphology",
        "name": "Abnormal chorioretinal morphology",
        "genes": 34,
        "url": "https://dantelabs.com/traits/abnormal-chorioretinal-morphology"
      },
      {
        "slug": "retinal-coloboma",
        "name": "Hole in the back of the eye",
        "genes": 32,
        "url": "https://dantelabs.com/traits/retinal-coloboma"
      },
      {
        "slug": "abnormal-macular-morphology",
        "name": "Abnormal macular morphology",
        "genes": 31,
        "url": "https://dantelabs.com/traits/abnormal-macular-morphology"
      },
      {
        "slug": "retinal-dysplasia",
        "name": "Retinal dysplasia",
        "genes": 28,
        "url": "https://dantelabs.com/traits/retinal-dysplasia"
      },
      {
        "slug": "retinal-hemorrhage",
        "name": "Retinal bleeding",
        "genes": 23,
        "url": "https://dantelabs.com/traits/retinal-hemorrhage"
      },
      {
        "slug": "angioid-streaks",
        "name": "Angioid streaks",
        "genes": 10,
        "url": "https://dantelabs.com/traits/angioid-streaks"
      },
      {
        "slug": "subretinal-fluid",
        "name": "Subretinal fluid",
        "genes": 10,
        "url": "https://dantelabs.com/traits/subretinal-fluid"
      },
      {
        "slug": "retinal-fold",
        "name": "Retinal fold",
        "genes": 8,
        "url": "https://dantelabs.com/traits/retinal-fold"
      },
      {
        "slug": "subretinal-deposits",
        "name": "Subretinal deposits",
        "genes": 7,
        "url": "https://dantelabs.com/traits/subretinal-deposits"
      },
      {
        "slug": "yellow-white-retinal-lesion",
        "name": "Yellow/white retinal lesion",
        "genes": 7,
        "url": "https://dantelabs.com/traits/yellow-white-retinal-lesion"
      },
      {
        "slug": "retinoschisis",
        "name": "Retinoschisis",
        "genes": 6,
        "url": "https://dantelabs.com/traits/retinoschisis"
      },
      {
        "slug": "retinal-hamartoma",
        "name": "Retinal hamartoma",
        "genes": 5,
        "url": "https://dantelabs.com/traits/retinal-hamartoma"
      },
      {
        "slug": "retinal-peau-d-orange",
        "name": "Retinal peau d'orange",
        "genes": 4,
        "url": "https://dantelabs.com/traits/retinal-peau-d-orange"
      },
      {
        "slug": "retinitis",
        "name": "Retinitis",
        "genes": 4,
        "url": "https://dantelabs.com/traits/retinitis"
      },
      {
        "slug": "abnormal-retinal-nerve-fiber-layer-morphology",
        "name": "Abnormal retinal nerve fiber layer morphology",
        "genes": 3,
        "url": "https://dantelabs.com/traits/abnormal-retinal-nerve-fiber-layer-morphology"
      },
      {
        "slug": "retinal-perforation",
        "name": "Retinal tear",
        "genes": 3,
        "url": "https://dantelabs.com/traits/retinal-perforation"
      },
      {
        "slug": "sub-rpe-deposits",
        "name": "Sub-RPE deposits",
        "genes": 2,
        "url": "https://dantelabs.com/traits/sub-rpe-deposits"
      },
      {
        "slug": "retinal-infarction",
        "name": "Retinal infarction",
        "genes": 1,
        "url": "https://dantelabs.com/traits/retinal-infarction"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-retina",
        "name": "Absent/small retina",
        "genes": 0,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-retina"
      },
      {
        "slug": "retinal-edema",
        "name": "Retinal edema",
        "genes": 0,
        "url": "https://dantelabs.com/traits/retinal-edema"
      },
      {
        "slug": "retinal-neoplasm",
        "name": "Retinal neoplasm",
        "genes": 0,
        "url": "https://dantelabs.com/traits/retinal-neoplasm"
      }
    ],
    "genes": [
      {
        "slug": "opn1sw",
        "symbol": "OPN1SW",
        "hgnc": "HGNC:1012",
        "name": "opsin 1, short wave sensitive",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opn1sw"
      },
      {
        "slug": "ca2",
        "symbol": "CA2",
        "hgnc": "HGNC:1373",
        "name": "carbonic anhydrase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca2"
      },
      {
        "slug": "fbxo22",
        "symbol": "FBXO22",
        "hgnc": "HGNC:13593",
        "name": "F-box protein 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo22"
      },
      {
        "slug": "katnb1",
        "symbol": "KATNB1",
        "hgnc": "HGNC:6217",
        "name": "katanin regulatory subunit B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/katnb1"
      },
      {
        "slug": "krt25",
        "symbol": "KRT25",
        "hgnc": "HGNC:30839",
        "name": "keratin 25",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt25"
      },
      {
        "slug": "krt71",
        "symbol": "KRT71",
        "hgnc": "HGNC:28927",
        "name": "keratin 71",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt71"
      },
      {
        "slug": "krt74",
        "symbol": "KRT74",
        "hgnc": "HGNC:28929",
        "name": "keratin 74",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt74"
      },
      {
        "slug": "liph",
        "symbol": "LIPH",
        "hgnc": "HGNC:18483",
        "name": "lipase H",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/liph"
      },
      {
        "slug": "lpar6",
        "symbol": "LPAR6",
        "hgnc": "HGNC:15520",
        "name": "lysophosphatidic acid receptor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lpar6"
      },
      {
        "slug": "nde1",
        "symbol": "NDE1",
        "hgnc": "HGNC:17619",
        "name": "nudE neurodevelopment protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nde1"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "reln",
        "symbol": "RELN",
        "hgnc": "HGNC:9957",
        "name": "reelin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/reln"
      },
      {
        "slug": "rrm1",
        "symbol": "RRM1",
        "hgnc": "HGNC:10451",
        "name": "ribonucleotide reductase catalytic subunit M1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm1"
      },
      {
        "slug": "tk2",
        "symbol": "TK2",
        "hgnc": "HGNC:11831",
        "name": "thymidine kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tk2"
      },
      {
        "slug": "top3a",
        "symbol": "TOP3A",
        "hgnc": "HGNC:11992",
        "name": "DNA topoisomerase III alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top3a"
      },
      {
        "slug": "atcay",
        "symbol": "ATCAY",
        "hgnc": "HGNC:779",
        "name": "ATCAY kinesin light chain interacting caytaxin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atcay"
      }
    ]
  }
}