{
  "url": "https://dantelabs.com/traits/abnormal-eye-physiology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-eye-physiology",
    "id": "HP:0012373",
    "name": "Abnormal eye physiology",
    "definition": "A functional anomaly of the eye.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "narrower": [
      {
        "slug": "ptosis",
        "name": "Drooping upper eyelid",
        "genes": 763,
        "url": "https://dantelabs.com/traits/ptosis"
      },
      {
        "slug": "glaucoma",
        "name": "Glaucoma",
        "genes": 357,
        "url": "https://dantelabs.com/traits/glaucoma"
      },
      {
        "slug": "abnormality-of-vision",
        "name": "Abnormality of vision",
        "genes": 176,
        "url": "https://dantelabs.com/traits/abnormality-of-vision"
      },
      {
        "slug": "abnormality-of-eye-movement",
        "name": "Abnormality of eye movement",
        "genes": 79,
        "url": "https://dantelabs.com/traits/abnormality-of-eye-movement"
      },
      {
        "slug": "lacrimation-abnormality",
        "name": "Abnormality of tear production",
        "genes": 34,
        "url": "https://dantelabs.com/traits/lacrimation-abnormality"
      },
      {
        "slug": "abnormality-of-refraction",
        "name": "Abnormality of refraction",
        "genes": 31,
        "url": "https://dantelabs.com/traits/abnormality-of-refraction"
      },
      {
        "slug": "inflammatory-abnormality-of-the-eye",
        "name": "Inflammatory abnormality of the eye",
        "genes": 16,
        "url": "https://dantelabs.com/traits/inflammatory-abnormality-of-the-eye"
      },
      {
        "slug": "ocular-pain",
        "name": "Eye pain",
        "genes": 13,
        "url": "https://dantelabs.com/traits/ocular-pain"
      },
      {
        "slug": "staring-gaze",
        "name": "Staring gaze",
        "genes": 12,
        "url": "https://dantelabs.com/traits/staring-gaze"
      },
      {
        "slug": "abnormal-pupillary-function",
        "name": "Abnormal pupillary function",
        "genes": 9,
        "url": "https://dantelabs.com/traits/abnormal-pupillary-function"
      },
      {
        "slug": "decreased-corneal-sensation",
        "name": "Decreased corneal sensation",
        "genes": 5,
        "url": "https://dantelabs.com/traits/decreased-corneal-sensation"
      },
      {
        "slug": "hemorrhage-of-the-eye",
        "name": "Bleeding from the eye",
        "genes": 4,
        "url": "https://dantelabs.com/traits/hemorrhage-of-the-eye"
      },
      {
        "slug": "corneal-foreign-body-sensation",
        "name": "Corneal foreign body sensation",
        "genes": 1,
        "url": "https://dantelabs.com/traits/corneal-foreign-body-sensation"
      },
      {
        "slug": "asthenopia",
        "name": "Eye strain",
        "genes": 1,
        "url": "https://dantelabs.com/traits/asthenopia"
      },
      {
        "slug": "abnormal-corneal-reflex",
        "name": "Abnormal corneal reflex",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-corneal-reflex"
      },
      {
        "slug": "abnormal-extraocular-muscle-physiology",
        "name": "Abnormal extraocular muscle physiology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-extraocular-muscle-physiology"
      },
      {
        "slug": "abnormal-intraocular-pressure",
        "name": "Abnormal intraocular pressure",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-intraocular-pressure"
      },
      {
        "slug": "abnormal-visual-electrophysiology",
        "name": "Abnormal visual electrophysiology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-visual-electrophysiology"
      }
    ],
    "genes": [
      {
        "slug": "pigt",
        "symbol": "PIGT",
        "hgnc": "HGNC:14938",
        "name": "phosphatidylinositol glycan anchor biosynthesis class T",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigt"
      },
      {
        "slug": "abcg5",
        "symbol": "ABCG5",
        "hgnc": "HGNC:13886",
        "name": "ATP binding cassette subfamily G member 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg5"
      },
      {
        "slug": "abcg8",
        "symbol": "ABCG8",
        "hgnc": "HGNC:13887",
        "name": "ATP binding cassette subfamily G member 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg8"
      },
      {
        "slug": "apob",
        "symbol": "APOB",
        "hgnc": "HGNC:603",
        "name": "apolipoprotein B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apob"
      },
      {
        "slug": "ldlr",
        "symbol": "LDLR",
        "hgnc": "HGNC:6547",
        "name": "low density lipoprotein receptor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldlr"
      },
      {
        "slug": "ldlrap1",
        "symbol": "LDLRAP1",
        "hgnc": "HGNC:18640",
        "name": "low density lipoprotein receptor adaptor protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldlrap1"
      },
      {
        "slug": "pcsk9",
        "symbol": "PCSK9",
        "hgnc": "HGNC:20001",
        "name": "proprotein convertase subtilisin/kexin type 9",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcsk9"
      }
    ]
  }
}