{
  "url": "https://dantelabs.com/sv/genes/wnt2b",
  "gene": {
    "slug": "wnt2b",
    "symbol": "WNT2B",
    "name": "Wnt family member 2B",
    "hgnc": "HGNC:12781",
    "summary": null,
    "location": "1p13.2",
    "locusType": "gene with protein product",
    "aliases": [
      "XWNT2"
    ],
    "previousSymbols": [
      "WNT13"
    ],
    "ensemblId": "ENSG00000134245",
    "entrezId": 7482,
    "omim": [
      "601968"
    ],
    "uniprot": [
      "Q93097"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "1",
      "start": 112508965,
      "end": 112530165,
      "strand": "+",
      "ensemblTranscript": "ENST00000369684.5",
      "refseqTranscript": "NM_024494.3",
      "ensemblProtein": "ENSP00000358698.4",
      "refseqProtein": "NP_078613.1",
      "exons": [
        {
          "start": 112508965,
          "end": 112509444
        },
        {
          "start": 112514874,
          "end": 112515094
        },
        {
          "start": 112516140,
          "end": 112516417
        },
        {
          "start": 112517121,
          "end": 112517385
        },
        {
          "start": 112520280,
          "end": 112530165
        }
      ],
      "cds": {
        "start": 112509263,
        "end": 112520509
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "1",
      "start": 113009163,
      "end": 113072787,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 112019565,
      "end": 113019564,
      "genes": [
        {
          "symbol": "CTTNBP2NL",
          "ensemblId": "ENSG00000143079",
          "biotype": "protein_coding",
          "start": 112396198,
          "end": 112463456,
          "strand": "+",
          "slug": "cttnbp2nl"
        },
        {
          "symbol": "ST7L",
          "ensemblId": "ENSG00000007341",
          "biotype": "protein_coding",
          "start": 112523473,
          "end": 112620825,
          "strand": "-",
          "slug": "st7l"
        },
        {
          "symbol": "CAPZA1",
          "ensemblId": "ENSG00000116489",
          "biotype": "protein_coding",
          "start": 112619173,
          "end": 112672747,
          "strand": "+",
          "slug": "capza1"
        },
        {
          "symbol": "MOV10",
          "ensemblId": "ENSG00000155363",
          "biotype": "protein_coding",
          "start": 112673141,
          "end": 112702415,
          "strand": "+",
          "slug": "mov10"
        },
        {
          "symbol": "RHOC",
          "ensemblId": "ENSG00000155366",
          "biotype": "protein_coding",
          "start": 112699765,
          "end": 112707897,
          "strand": "-",
          "slug": "rhoc"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000271810",
          "biotype": "protein_coding",
          "start": 112702614,
          "end": 112711433,
          "strand": "-"
        },
        {
          "symbol": "PPM1J",
          "ensemblId": "ENSG00000155367",
          "biotype": "protein_coding",
          "start": 112709994,
          "end": 112715502,
          "strand": "-",
          "slug": "ppm1j"
        },
        {
          "symbol": "TAFA3",
          "ensemblId": "ENSG00000184599",
          "biotype": "protein_coding",
          "start": 112718881,
          "end": 112729076,
          "strand": "+",
          "slug": "tafa3"
        },
        {
          "symbol": "SLC16A1",
          "ensemblId": "ENSG00000155380",
          "biotype": "protein_coding",
          "start": 112904043,
          "end": 112957593,
          "strand": "-",
          "slug": "slc16a1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "congenital-diarrhoeas-and-enteropathies",
        "name": "Medfödd diarré och enteropatier",
        "diseases": [
          {
            "mondoId": "MONDO:0000824",
            "name": "Medfödd diarré",
            "genes": 12,
            "inheritance": null,
            "description": "Ärftliga tillstånd, inklusive medfödd kloriddiarré (SLC26A3), microvillus inclusion disease (MYO5B), tufting enteropathy (EPCAM) och medfödd natriumdiarré (SPINT2, SLC9A3), som orsakar kronisk diarré från tidig spädbarnsålder.",
            "management": "En specifik diagnos styr behandlingen, till exempel elektrolytersättning vid kloriddiarré, eller tidig planering för parenteral nutrition eller tarmtransplantation vid microvillus inclusion disease och tufting enteropathy.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/sv/conditions/congenital-diarrhoeas-and-enteropathies"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "villous-atrophy",
        "name": "Villous atrophy",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/villous-atrophy"
      }
    ],
    "related": [
      {
        "slug": "dgat1",
        "symbol": "DGAT1",
        "name": "diacylglycerol O-acyltransferase 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/dgat1"
      },
      {
        "slug": "epcam",
        "symbol": "EPCAM",
        "name": "epithelial cell adhesion molecule",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/epcam"
      },
      {
        "slug": "gucy2c",
        "symbol": "GUCY2C",
        "name": "guanylate cyclase 2C",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/gucy2c"
      },
      {
        "slug": "myo5b",
        "symbol": "MYO5B",
        "name": "myosin VB",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/myo5b"
      },
      {
        "slug": "neurog3",
        "symbol": "NEUROG3",
        "name": "neurogenin 3",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/neurog3"
      },
      {
        "slug": "plvap",
        "symbol": "PLVAP",
        "name": "plasmalemma vesicle associated protein",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/plvap"
      },
      {
        "slug": "slc26a3",
        "symbol": "SLC26A3",
        "name": "solute carrier family 26 member 3",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/slc26a3"
      },
      {
        "slug": "slc5a1",
        "symbol": "SLC5A1",
        "name": "solute carrier family 5 member 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/slc5a1"
      },
      {
        "slug": "slc9a3",
        "symbol": "SLC9A3",
        "name": "solute carrier family 9 member A3",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/slc9a3"
      },
      {
        "slug": "spint2",
        "symbol": "SPINT2",
        "name": "serine peptidase inhibitor, Kunitz type 2",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/spint2"
      },
      {
        "slug": "stx3",
        "symbol": "STX3",
        "name": "syntaxin 3",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/stx3"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}