{
  "url": "https://dantelabs.com/sv/genes/wdr37",
  "gene": {
    "slug": "wdr37",
    "symbol": "WDR37",
    "name": "WD repeat domain 37",
    "hgnc": "HGNC:31406",
    "summary": null,
    "location": "10p15.3",
    "locusType": "gene with protein product",
    "aliases": [
      "KIAA0982"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000047056",
    "entrezId": 22884,
    "omim": [
      "618586"
    ],
    "uniprot": [
      "Q9Y2I8"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 1056385,
      "end": 1132372,
      "strand": "+",
      "ensemblTranscript": "ENST00000263150.9",
      "refseqTranscript": "NM_014023.4",
      "ensemblProtein": "ENSP00000263150.4",
      "refseqProtein": "NP_054742.2",
      "exons": [
        {
          "start": 1056385,
          "end": 1056968
        },
        {
          "start": 1072116,
          "end": 1072293
        },
        {
          "start": 1077907,
          "end": 1078003
        },
        {
          "start": 1080011,
          "end": 1080106
        },
        {
          "start": 1080412,
          "end": 1080476
        },
        {
          "start": 1084403,
          "end": 1084538
        },
        {
          "start": 1086286,
          "end": 1086357
        },
        {
          "start": 1093452,
          "end": 1093496
        },
        {
          "start": 1096170,
          "end": 1096246
        },
        {
          "start": 1103602,
          "end": 1103836
        },
        {
          "start": 1105126,
          "end": 1105267
        },
        {
          "start": 1124218,
          "end": 1124352
        },
        {
          "start": 1124910,
          "end": 1125024
        },
        {
          "start": 1129213,
          "end": 1132372
        }
      ],
      "cds": {
        "start": 1072156,
        "end": 1129344
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 1095478,
      "end": 1178237,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 594379,
      "end": 1594378,
      "genes": [
        {
          "symbol": "DIP2C",
          "ensemblId": "ENSG00000151240",
          "biotype": "protein_coding",
          "start": 274201,
          "end": 689937,
          "strand": "-",
          "slug": "dip2c"
        },
        {
          "symbol": "LARP4B",
          "ensemblId": "ENSG00000107929",
          "biotype": "protein_coding",
          "start": 803911,
          "end": 931821,
          "strand": "-",
          "slug": "larp4b"
        },
        {
          "symbol": "GTPBP4",
          "ensemblId": "ENSG00000107937",
          "biotype": "protein_coding",
          "start": 988409,
          "end": 1020001,
          "strand": "+",
          "slug": "gtpbp4"
        },
        {
          "symbol": "IDI2",
          "ensemblId": "ENSG00000148377",
          "biotype": "protein_coding",
          "start": 1018908,
          "end": 1025861,
          "strand": "-",
          "slug": "idi2"
        },
        {
          "symbol": "IDI1",
          "ensemblId": "ENSG00000067064",
          "biotype": "protein_coding",
          "start": 1037732,
          "end": 1049364,
          "strand": "-",
          "slug": "idi1"
        },
        {
          "symbol": "ADARB2",
          "ensemblId": "ENSG00000185736",
          "biotype": "protein_coding",
          "start": 1177308,
          "end": 1737525,
          "strand": "-",
          "slug": "adarb2"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-cerebellum-morphology",
        "name": "Abnormality of the cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-cerebellum-morphology"
      },
      {
        "slug": "abnormal-palmar-crease-morphology",
        "name": "Abnormality of the palm lines",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-palmar-crease-morphology"
      },
      {
        "slug": "microphthalmia",
        "name": "Abnormally small eyeball",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/microphthalmia"
      },
      {
        "slug": "absent-speech",
        "name": "Absent speech development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/absent-speech"
      },
      {
        "slug": "atrial-septal-defect",
        "name": "An opening in the wall separating the top two chambers of the heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/atrial-septal-defect"
      },
      {
        "slug": "bilateral-cryptorchidism",
        "name": "Bilateral cryptorchidism",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bilateral-cryptorchidism"
      },
      {
        "slug": "secondary-microcephaly",
        "name": "Development of small head that was not present at birth",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/secondary-microcephaly"
      },
      {
        "slug": "downturned-corners-of-mouth",
        "name": "Downturned corners of mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/downturned-corners-of-mouth"
      },
      {
        "slug": "cardiomegaly",
        "name": "Enlarged heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cardiomegaly"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "epicanthus",
        "name": "Eye folds",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/epicanthus"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "high-forehead",
        "name": "High forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/high-forehead"
      },
      {
        "slug": "ventricular-septal-defect",
        "name": "Hole in heart wall separating two lower heart chambers",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ventricular-septal-defect"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "low-set-ears",
        "name": "Low-set ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/low-set-ears"
      },
      {
        "slug": "coloboma",
        "name": "Notched pupil",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/coloboma"
      },
      {
        "slug": "patent-ductus-arteriosus",
        "name": "Patent ductus arteriosus",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/patent-ductus-arteriosus"
      },
      {
        "slug": "patent-foramen-ovale",
        "name": "Patent foramen ovale",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/patent-foramen-ovale"
      },
      {
        "slug": "peters-anomaly",
        "name": "Peters anomaly",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/peters-anomaly"
      },
      {
        "slug": "prominent-nasal-bridge",
        "name": "Prominent nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/prominent-nasal-bridge"
      },
      {
        "slug": "redundant-neck-skin",
        "name": "Redundant neck skin",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/redundant-neck-skin"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "smooth-philtrum",
        "name": "Smooth philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/smooth-philtrum"
      },
      {
        "slug": "tricuspid-regurgitation",
        "name": "Tricuspid regurgitation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tricuspid-regurgitation"
      },
      {
        "slug": "hypertelorism",
        "name": "Wide-set eyes",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypertelorism"
      },
      {
        "slug": "wide-intermamillary-distance",
        "name": "Wide-spaced nipples",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/wide-intermamillary-distance"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}