{
  "url": "https://dantelabs.com/sv/genes/tf",
  "gene": {
    "slug": "tf",
    "symbol": "TF",
    "name": "transferrin",
    "hgnc": "HGNC:11740",
    "summary": null,
    "location": "3q22.1",
    "locusType": "gene with protein product",
    "aliases": [
      "PRO1557",
      "PRO2086"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000091513",
    "entrezId": 7018,
    "omim": [
      "190000"
    ],
    "uniprot": [
      "P02787"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "3",
      "start": 133746393,
      "end": 133796641,
      "strand": "+",
      "ensemblTranscript": "ENST00000402696.9",
      "refseqTranscript": "NM_001063.4",
      "ensemblProtein": "ENSP00000385834.3",
      "refseqProtein": "NP_001054.2",
      "exons": [
        {
          "start": 133746393,
          "end": 133746483
        },
        {
          "start": 133748412,
          "end": 133748584
        },
        {
          "start": 133753595,
          "end": 133753703
        },
        {
          "start": 133754495,
          "end": 133754671
        },
        {
          "start": 133755363,
          "end": 133755495
        },
        {
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        },
        {
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          "end": 133759329
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        {
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        },
        {
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          "end": 133764907
        },
        {
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        },
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        },
        {
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        },
        {
          "start": 133777049,
          "end": 133777238
        },
        {
          "start": 133778586,
          "end": 133796641
        }
      ],
      "cds": {
        "start": 133746441,
        "end": 133778620
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
      "start": 133464800,
      "end": 133497850,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 133271517,
      "end": 134271516,
      "genes": [
        {
          "symbol": "TMEM108",
          "ensemblId": "ENSG00000144868",
          "biotype": "protein_coding",
          "start": 133038276,
          "end": 133397775,
          "strand": "+",
          "slug": "tmem108"
        },
        {
          "symbol": "BFSP2",
          "ensemblId": "ENSG00000170819",
          "biotype": "protein_coding",
          "start": 133400056,
          "end": 133475222,
          "strand": "+",
          "slug": "bfsp2"
        },
        {
          "symbol": "CDV3",
          "ensemblId": "ENSG00000091527",
          "biotype": "protein_coding",
          "start": 133573543,
          "end": 133590274,
          "strand": "+",
          "slug": "cdv3"
        },
        {
          "symbol": "TOPBP1",
          "ensemblId": "ENSG00000163781",
          "biotype": "protein_coding",
          "start": 133598175,
          "end": 133662380,
          "strand": "-",
          "slug": "topbp1"
        },
        {
          "symbol": "SRPRB",
          "ensemblId": "ENSG00000144867",
          "biotype": "protein_coding",
          "start": 133784023,
          "end": 133825772,
          "strand": "+",
          "slug": "srprb"
        },
        {
          "symbol": "RAB6B",
          "ensemblId": "ENSG00000154917",
          "biotype": "protein_coding",
          "start": 133819939,
          "end": 133895889,
          "strand": "-",
          "slug": "rab6b"
        },
        {
          "symbol": "SLCO2A1",
          "ensemblId": "ENSG00000174640",
          "biotype": "protein_coding",
          "start": 133930258,
          "end": 134052184,
          "strand": "-",
          "slug": "slco2a1"
        },
        {
          "symbol": "RYK",
          "ensemblId": "ENSG00000163785",
          "biotype": "protein_coding",
          "start": 134065303,
          "end": 134250929,
          "strand": "-",
          "slug": "ryk"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "inherited-iron-metabolism-disorders",
        "name": "Ärftliga järnmetabolismrubbningar",
        "diseases": [
          {
            "mondoId": "MONDO:0008846",
            "name": "Atransferrinemi",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Orsakas av förändringar i TF. Nästan fullständig avsaknad av transferrin, det järnbärande proteinet, leder till svår anemi tillsammans med järnöverskott i organen.",
            "management": "Infusioner av plasma eller transferrin kan korrigera anemin, och järnöverskottet kan följas upp.",
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/sv/conditions/inherited-iron-metabolism-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "systems": [],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-liver",
        "name": "Abnormality of the liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/abnormality-of-the-liver"
      },
      {
        "slug": "abnormality-of-the-pancreas",
        "name": "Abnormality of the pancreas",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-pancreas"
      },
      {
        "slug": "arthritis",
        "name": "Arthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arthritis"
      },
      {
        "slug": "atransferrinemia",
        "name": "Atransferrinemia",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/atransferrinemia"
      },
      {
        "slug": "congestive-heart-failure",
        "name": "Cardiac failure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/congestive-heart-failure"
      },
      {
        "slug": "hypochromic-anemia",
        "name": "Hypochromic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/hypochromic-anemia"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "recurrent-infections",
        "name": "Recurrent infections",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-infections"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}