{
  "url": "https://dantelabs.com/sv/genes/slc22a4",
  "gene": {
    "slug": "slc22a4",
    "symbol": "SLC22A4",
    "name": "solute carrier family 22 member 4",
    "hgnc": "HGNC:10968",
    "summary": null,
    "location": "5q31.1",
    "locusType": "gene with protein product",
    "aliases": [
      "OCTN1",
      "MGC34546"
    ],
    "previousSymbols": [
      "DFNB60"
    ],
    "ensemblId": "ENSG00000197208",
    "entrezId": 6583,
    "omim": [
      "604190"
    ],
    "uniprot": [
      "Q9H015"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "5",
      "start": 132294394,
      "end": 132344190,
      "strand": "+",
      "ensemblTranscript": "ENST00000200652.4",
      "refseqTranscript": "NM_003059.3",
      "ensemblProtein": "ENSP00000200652.3",
      "refseqProtein": "NP_003050.2",
      "exons": [
        {
          "start": 132294394,
          "end": 132295009
        },
        {
          "start": 132312161,
          "end": 132312264
        },
        {
          "start": 132313614,
          "end": 132313768
        },
        {
          "start": 132322184,
          "end": 132322355
        },
        {
          "start": 132327277,
          "end": 132327403
        },
        {
          "start": 132331756,
          "end": 132331850
        },
        {
          "start": 132334718,
          "end": 132334932
        },
        {
          "start": 132335818,
          "end": 132336000
        },
        {
          "start": 132340565,
          "end": 132340700
        },
        {
          "start": 132343760,
          "end": 132344190
        }
      ],
      "cds": {
        "start": 132294617,
        "end": 132343835
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "5",
      "start": 131630136,
      "end": 131679899,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 131819292,
      "end": 132819291,
      "genes": [
        {
          "symbol": "MEIKIN",
          "ensemblId": "ENSG00000239642",
          "biotype": "protein_coding",
          "start": 131806990,
          "end": 131945698,
          "strand": "-",
          "slug": "meikin"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000281938",
          "biotype": "protein_coding",
          "start": 131807143,
          "end": 132011637,
          "strand": "-"
        },
        {
          "symbol": "ACSL6",
          "ensemblId": "ENSG00000164398",
          "biotype": "protein_coding",
          "start": 131949973,
          "end": 132012243,
          "strand": "-",
          "slug": "acsl6"
        },
        {
          "symbol": "IL3",
          "ensemblId": "ENSG00000164399",
          "biotype": "protein_coding",
          "start": 132060655,
          "end": 132063204,
          "strand": "+",
          "slug": "il3"
        },
        {
          "symbol": "CSF2",
          "ensemblId": "ENSG00000164400",
          "biotype": "protein_coding",
          "start": 132073784,
          "end": 132076170,
          "strand": "+",
          "slug": "csf2"
        },
        {
          "symbol": "P4HA2",
          "ensemblId": "ENSG00000072682",
          "biotype": "protein_coding",
          "start": 132190094,
          "end": 132295315,
          "strand": "-",
          "slug": "p4ha2"
        },
        {
          "symbol": "PDLIM4",
          "ensemblId": "ENSG00000131435",
          "biotype": "protein_coding",
          "start": 132257640,
          "end": 132273712,
          "strand": "+",
          "slug": "pdlim4"
        },
        {
          "symbol": "SLC22A5",
          "ensemblId": "ENSG00000197375",
          "biotype": "protein_coding",
          "start": 132369493,
          "end": 132395615,
          "strand": "+",
          "slug": "slc22a5"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000283782",
          "biotype": "protein_coding",
          "start": 132410832,
          "end": 132646079,
          "strand": "+"
        },
        {
          "symbol": "IRF1",
          "ensemblId": "ENSG00000125347",
          "biotype": "protein_coding",
          "start": 132440440,
          "end": 132508719,
          "strand": "-",
          "slug": "irf1"
        },
        {
          "symbol": "IL5",
          "ensemblId": "ENSG00000113525",
          "biotype": "protein_coding",
          "start": 132541444,
          "end": 132556838,
          "strand": "-",
          "slug": "il5"
        },
        {
          "symbol": "RAD50",
          "ensemblId": "ENSG00000113522",
          "biotype": "protein_coding",
          "start": 132556019,
          "end": 132646349,
          "strand": "+",
          "slug": "rad50"
        },
        {
          "symbol": "IL13",
          "ensemblId": "ENSG00000169194",
          "biotype": "protein_coding",
          "start": 132656263,
          "end": 132661110,
          "strand": "+",
          "slug": "il13"
        },
        {
          "symbol": "IL4",
          "ensemblId": "ENSG00000113520",
          "biotype": "protein_coding",
          "start": 132673986,
          "end": 132682678,
          "strand": "+",
          "slug": "il4"
        },
        {
          "symbol": "KIF3A",
          "ensemblId": "ENSG00000131437",
          "biotype": "protein_coding",
          "start": 132688806,
          "end": 132737638,
          "strand": "-",
          "slug": "kif3a"
        },
        {
          "symbol": "CCNI2",
          "ensemblId": "ENSG00000205089",
          "biotype": "protein_coding",
          "start": 132747319,
          "end": 132765178,
          "strand": "+",
          "slug": "ccni2"
        },
        {
          "symbol": "SEPTIN8",
          "ensemblId": "ENSG00000164402",
          "biotype": "protein_coding",
          "start": 132750138,
          "end": 132807241,
          "strand": "-",
          "slug": "septin8"
        },
        {
          "symbol": "SOWAHA",
          "ensemblId": "ENSG00000198944",
          "biotype": "protein_coding",
          "start": 132813302,
          "end": 132816786,
          "strand": "+",
          "slug": "sowaha"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "anti-citrullinated-protein-antibody-positivity",
        "name": "Anti-citrullinated protein antibody positivity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/anti-citrullinated-protein-antibody-positivity"
      },
      {
        "slug": "elevated-circulating-c-reactive-protein-concentration",
        "name": "Elevated circulating C-reactive protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/elevated-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "elevated-erythrocyte-sedimentation-rate",
        "name": "High ESR",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/elevated-erythrocyte-sedimentation-rate"
      },
      {
        "slug": "vasculitis",
        "name": "Inflammation of blood vessel",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/vasculitis"
      },
      {
        "slug": "interphalangeal-joint-erosions",
        "name": "Interphalangeal joint erosions",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/interphalangeal-joint-erosions"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "joint-stiffness",
        "name": "Joint stiffness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/joint-stiffness"
      },
      {
        "slug": "joint-swelling",
        "name": "Joint swelling",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/joint-swelling"
      },
      {
        "slug": "polyarticular-arthritis",
        "name": "Polyarticular arthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/polyarticular-arthritis"
      },
      {
        "slug": "rheumatoid-arthritis",
        "name": "Rheumatoid arthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/rheumatoid-arthritis"
      },
      {
        "slug": "rheumatoid-factor-positive",
        "name": "Rheumatoid factor positive",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/rheumatoid-factor-positive"
      },
      {
        "slug": "swan-neck-like-deformities-of-the-fingers",
        "name": "Swan neck-like deformities of the fingers",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/swan-neck-like-deformities-of-the-fingers"
      },
      {
        "slug": "digital-flexor-tenosynovitis",
        "name": "Trigger finger",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/digital-flexor-tenosynovitis"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "url": "https://dantelabs.com/traits/weight-loss"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}