{
  "url": "https://dantelabs.com/sv/genes/rad51d",
  "gene": {
    "slug": "rad51d",
    "symbol": "RAD51D",
    "name": "RAD51 paralog D",
    "hgnc": "HGNC:9823",
    "summary": null,
    "location": "17q12",
    "locusType": "gene with protein product",
    "aliases": [
      "R51H3",
      "Trad",
      "HsTRAD"
    ],
    "previousSymbols": [
      "RAD51L3"
    ],
    "ensemblId": "ENSG00000185379",
    "entrezId": 5892,
    "omim": [
      "602954"
    ],
    "uniprot": [
      "O75771"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 35092221,
      "end": 35119860,
      "strand": "-",
      "ensemblTranscript": "ENST00000345365.11",
      "refseqTranscript": "NM_002878.4",
      "ensemblProtein": "ENSP00000338790.6",
      "refseqProtein": "NP_002869.3",
      "exons": [
        {
          "start": 35092221,
          "end": 35101036
        },
        {
          "start": 35101201,
          "end": 35101365
        },
        {
          "start": 35103254,
          "end": 35103324
        },
        {
          "start": 35103454,
          "end": 35103544
        },
        {
          "start": 35106386,
          "end": 35106481
        },
        {
          "start": 35106988,
          "end": 35107122
        },
        {
          "start": 35107366,
          "end": 35107447
        },
        {
          "start": 35118501,
          "end": 35118619
        },
        {
          "start": 35119111,
          "end": 35119172
        },
        {
          "start": 35119532,
          "end": 35119860
        }
      ],
      "cds": {
        "start": 35100953,
        "end": 35119613
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
      "start": 33426811,
      "end": 33448541,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 34606041,
      "end": 35606040,
      "genes": [
        {
          "symbol": "TMEM132E",
          "ensemblId": "ENSG00000181291",
          "biotype": "protein_coding",
          "start": 34579487,
          "end": 34639318,
          "strand": "+",
          "slug": "tmem132e"
        },
        {
          "symbol": "CCT6B",
          "ensemblId": "ENSG00000132141",
          "biotype": "protein_coding",
          "start": 34927842,
          "end": 34981078,
          "strand": "-",
          "slug": "cct6b"
        },
        {
          "symbol": "ZNF830",
          "ensemblId": "ENSG00000198783",
          "biotype": "protein_coding",
          "start": 34961540,
          "end": 34963777,
          "strand": "+",
          "slug": "znf830"
        },
        {
          "symbol": "LIG3",
          "ensemblId": "ENSG00000005156",
          "biotype": "protein_coding",
          "start": 34980462,
          "end": 35009743,
          "strand": "+",
          "slug": "lig3"
        },
        {
          "symbol": "RFFL",
          "ensemblId": "ENSG00000092871",
          "biotype": "protein_coding",
          "start": 35005990,
          "end": 35089899,
          "strand": "-",
          "slug": "rffl"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000267618",
          "biotype": "protein_coding",
          "start": 35011349,
          "end": 35121493,
          "strand": "-"
        },
        {
          "symbol": "FNDC8",
          "ensemblId": "ENSG00000073598",
          "biotype": "protein_coding",
          "start": 35121615,
          "end": 35130732,
          "strand": "+",
          "slug": "fndc8"
        },
        {
          "symbol": "NLE1",
          "ensemblId": "ENSG00000073536",
          "biotype": "protein_coding",
          "start": 35125556,
          "end": 35142313,
          "strand": "-",
          "slug": "nle1"
        },
        {
          "symbol": "UNC45B",
          "ensemblId": "ENSG00000141161",
          "biotype": "protein_coding",
          "start": 35146495,
          "end": 35189346,
          "strand": "+",
          "slug": "unc45b"
        },
        {
          "symbol": "SLC35G3",
          "ensemblId": "ENSG00000164729",
          "biotype": "protein_coding",
          "start": 35192520,
          "end": 35194393,
          "strand": "-",
          "slug": "slc35g3"
        },
        {
          "symbol": "SLFN5",
          "ensemblId": "ENSG00000166750",
          "biotype": "protein_coding",
          "start": 35243043,
          "end": 35273655,
          "strand": "+",
          "slug": "slfn5"
        },
        {
          "symbol": "SLFN11",
          "ensemblId": "ENSG00000172716",
          "biotype": "protein_coding",
          "start": 35350305,
          "end": 35373701,
          "strand": "-",
          "slug": "slfn11"
        },
        {
          "symbol": "SLFN12",
          "ensemblId": "ENSG00000172123",
          "biotype": "protein_coding",
          "start": 35409339,
          "end": 35433475,
          "strand": "-",
          "slug": "slfn12"
        },
        {
          "symbol": "SLFN13",
          "ensemblId": "ENSG00000154760",
          "biotype": "protein_coding",
          "start": 35435096,
          "end": 35449766,
          "strand": "-",
          "slug": "slfn13"
        },
        {
          "symbol": "SLFN12L",
          "ensemblId": "ENSG00000205045",
          "biotype": "protein_coding",
          "start": 35464249,
          "end": 35537770,
          "strand": "-",
          "slug": "slfn12l"
        },
        {
          "symbol": "SLFN14",
          "ensemblId": "ENSG00000236320",
          "biotype": "protein_coding",
          "start": 35543985,
          "end": 35560819,
          "strand": "-",
          "slug": "slfn14"
        },
        {
          "symbol": "PEX12",
          "ensemblId": "ENSG00000108733",
          "biotype": "protein_coding",
          "start": 35574795,
          "end": 35578863,
          "strand": "-",
          "slug": "pex12"
        },
        {
          "symbol": "AP2B1",
          "ensemblId": "ENSG00000006125",
          "biotype": "protein_coding",
          "start": 35578046,
          "end": 35726417,
          "strand": "+",
          "slug": "ap2b1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "moderate-penetrance-breast-ovarian-cancer-genes",
        "name": "Gener för bröst- och äggstockscancer utöver BRCA1/2",
        "diseases": [
          {
            "mondoId": "MONDO:0700274",
            "name": "Cancerpredisposition relaterad till RAD51D",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "Varianter i RAD51D som ökar risken för äggstockscancer och, i mindre grad, bröstcancer.",
            "management": "Borttagning av äggstockar och äggledare övervägs ofta från mitten av 40-årsåldern för att minska risken för äggstockscancer.",
            "evidence": {
              "gencc": [
                "ClinGen"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0013669",
            "name": "Familjär bröst-äggstockscancer, känslighet 4 (RAD51D)",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "Känslighet för bröst- och äggstockscancer relaterad till RAD51D.",
            "management": null,
            "evidence": {
              "gencc": [
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ],
              "actionability": 7
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/sv/conditions/moderate-penetrance-breast-ovarian-cancer-genes"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-fallopian-tube-morphology",
        "name": "Abnormal fallopian tube morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-fallopian-tube-morphology"
      },
      {
        "slug": "breast-carcinoma",
        "name": "Breast cancer",
        "systems": [
          "abnormality-of-the-breast",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/breast-carcinoma"
      },
      {
        "slug": "melanoma",
        "name": "Cancer of skin pigment cells",
        "systems": [
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/melanoma"
      },
      {
        "slug": "neoplasm-of-the-pancreas",
        "name": "Cancer of the pancreas",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-pancreas"
      },
      {
        "slug": "ovarian-neoplasm",
        "name": "Ovarian cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/ovarian-neoplasm"
      },
      {
        "slug": "primary-peritoneal-carcinoma",
        "name": "Primary peritoneal carcinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/primary-peritoneal-carcinoma"
      },
      {
        "slug": "prostate-cancer",
        "name": "Prostate cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prostate-cancer"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}