{
  "url": "https://dantelabs.com/sv/genes/pros1",
  "gene": {
    "slug": "pros1",
    "symbol": "PROS1",
    "name": "protein S",
    "hgnc": "HGNC:9456",
    "summary": null,
    "location": "3q11.1",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "PROS"
    ],
    "ensemblId": "ENSG00000184500",
    "entrezId": 5627,
    "omim": [
      "176880"
    ],
    "uniprot": [
      "P07225"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "3",
      "start": 93873051,
      "end": 93973896,
      "strand": "-",
      "ensemblTranscript": "ENST00000394236.9",
      "refseqTranscript": "NM_000313.4",
      "ensemblProtein": "ENSP00000377783.3",
      "refseqProtein": "NP_000304.2",
      "exons": [
        {
          "start": 93873051,
          "end": 93874405
        },
        {
          "start": 93876966,
          "end": 93877191
        },
        {
          "start": 93879163,
          "end": 93879314
        },
        {
          "start": 93884728,
          "end": 93884896
        },
        {
          "start": 93886336,
          "end": 93886503
        },
        {
          "start": 93892933,
          "end": 93893122
        },
        {
          "start": 93896576,
          "end": 93896691
        },
        {
          "start": 93898448,
          "end": 93898569
        },
        {
          "start": 93900804,
          "end": 93900929
        },
        {
          "start": 93905784,
          "end": 93905915
        },
        {
          "start": 93906021,
          "end": 93906143
        },
        {
          "start": 93910619,
          "end": 93910705
        },
        {
          "start": 93924240,
          "end": 93924264
        },
        {
          "start": 93927250,
          "end": 93927407
        },
        {
          "start": 93973674,
          "end": 93973896
        }
      ],
      "cds": {
        "start": 93874245,
        "end": 93973749
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
      "start": 93591881,
      "end": 93692910,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 93423474,
      "end": 94423473,
      "genes": [
        {
          "symbol": "ARL13B",
          "ensemblId": "ENSG00000169379",
          "biotype": "protein_coding",
          "start": 93980128,
          "end": 94055678,
          "strand": "+",
          "slug": "arl13b"
        },
        {
          "symbol": "DHFR2",
          "ensemblId": "ENSG00000178700",
          "biotype": "protein_coding",
          "start": 93981180,
          "end": 94063389,
          "strand": "-",
          "slug": "dhfr2"
        },
        {
          "symbol": "STX19",
          "ensemblId": "ENSG00000178750",
          "biotype": "protein_coding",
          "start": 94012043,
          "end": 94028658,
          "strand": "-",
          "slug": "stx19"
        },
        {
          "symbol": "NSUN3",
          "ensemblId": "ENSG00000178694",
          "biotype": "protein_coding",
          "start": 94062980,
          "end": 94131832,
          "strand": "+",
          "slug": "nsun3"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "thrombophilia",
        "name": "Trombofili",
        "diseases": [
          {
            "mondoId": "MONDO:0002304",
            "name": "Brist på protein S",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "En ärftlig brist på det naturliga antikoagulerande proteinet protein S, orsakad av förändringar i PROS1, som ökar risken för blodproppar i venerna.",
            "management": "Att känna till detta underlättar beslut om förebyggande av blodproppar vid operation, graviditet och läkemedel som innehåller östrogen.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ],
              "actionability": 8
            },
            "sameAsReport": false,
            "broad": false
          },
          {
            "mondoId": "MONDO:0100240",
            "name": "Ärftlig trombofili",
            "genes": 9,
            "inheritance": null,
            "description": null,
            "management": "Antikoagulation (behandlingstid beroende på genotyp); undvik östrogenhaltiga preventivmedel; LMWH för profylax under graviditet; förlängd antikoagulation efter operation; livslång antikoagulation vid sammansatta genotyper eller genotyper med hög risk",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant",
                "autosomal-recessive"
              ],
              "actionability": 8
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/sv/conditions/thrombophilia"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-skin-pigmentation",
        "name": "Abnormal skin pigmentation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-skin-pigmentation"
      },
      {
        "slug": "abnormal-cerebral-vascular-morphology",
        "name": "Abnormality of the cerebral blood vessels",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-cerebral-vascular-morphology"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-skin",
        "name": "Absent/small skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-skin"
      },
      {
        "slug": "subcutaneous-hemorrhage",
        "name": "Bleeding below the skin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/subcutaneous-hemorrhage"
      },
      {
        "slug": "cerebral-hemorrhage",
        "name": "Bleeding in brain",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/cerebral-hemorrhage"
      },
      {
        "slug": "blindness",
        "name": "Blindness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/blindness"
      },
      {
        "slug": "deep-venous-thrombosis",
        "name": "Blood clot in a deep vein",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/deep-venous-thrombosis"
      },
      {
        "slug": "arterial-thrombosis",
        "name": "Blood clot in artery",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arterial-thrombosis"
      },
      {
        "slug": "pulmonary-embolism",
        "name": "Blood clot in artery of lung",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pulmonary-embolism"
      },
      {
        "slug": "cerebral-venous-thrombosis",
        "name": "Blood clot in cerebral vein",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/cerebral-venous-thrombosis"
      },
      {
        "slug": "purpura",
        "name": "Blood spots",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/purpura"
      },
      {
        "slug": "gangrene",
        "name": "Death of body tissue due to lack of blood flow or infection",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gangrene"
      },
      {
        "slug": "disseminated-intravascular-coagulation",
        "name": "Disseminated intravascular coagulation",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/disseminated-intravascular-coagulation"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "hypercoagulability",
        "name": "Hypercoagulability",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypercoagulability"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "retinopathy",
        "name": "Noninflammatory retina disease",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/retinopathy"
      },
      {
        "slug": "skin-ulcer",
        "name": "Open skin sore",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/skin-ulcer"
      },
      {
        "slug": "venous-insufficiency",
        "name": "Poorly functioning veins",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/venous-insufficiency"
      },
      {
        "slug": "reduced-protein-s-activity",
        "name": "Reduced protein S activity",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-protein-s-activity"
      },
      {
        "slug": "superficial-thrombophlebitis",
        "name": "Superficial thrombophlebitis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/superficial-thrombophlebitis"
      },
      {
        "slug": "thin-skin",
        "name": "Thin skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thin-skin"
      },
      {
        "slug": "thrombophlebitis",
        "name": "Thrombophlebitis",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/thrombophlebitis"
      },
      {
        "slug": "warfarin-induced-skin-necrosis",
        "name": "Warfarin-induced skin necrosis",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/warfarin-induced-skin-necrosis"
      }
    ],
    "related": [
      {
        "slug": "f2",
        "symbol": "F2",
        "name": "coagulation factor II, thrombin",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/f2"
      },
      {
        "slug": "f5",
        "symbol": "F5",
        "name": "coagulation factor V",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/f5"
      },
      {
        "slug": "f9",
        "symbol": "F9",
        "name": "coagulation factor IX",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/f9"
      },
      {
        "slug": "hrg",
        "symbol": "HRG",
        "name": "histidine rich glycoprotein",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/hrg"
      },
      {
        "slug": "proc",
        "symbol": "PROC",
        "name": "protein C, inactivator of coagulation factors Va and VIIIa",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/proc"
      },
      {
        "slug": "serpinc1",
        "symbol": "SERPINC1",
        "name": "serpin family C member 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/serpinc1"
      },
      {
        "slug": "serpind1",
        "symbol": "SERPIND1",
        "name": "serpin family D member 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/serpind1"
      },
      {
        "slug": "thbd",
        "symbol": "THBD",
        "name": "thrombomodulin",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/thbd"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-8b139e39",
      "panel": "2026-10-18",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}