{
  "url": "https://dantelabs.com/sv/genes/pdcd10",
  "gene": {
    "slug": "pdcd10",
    "symbol": "PDCD10",
    "name": "programmed cell death 10",
    "hgnc": "HGNC:8761",
    "summary": null,
    "location": "3q26.1",
    "locusType": "gene with protein product",
    "aliases": [
      "TFAR15"
    ],
    "previousSymbols": [
      "CCM3"
    ],
    "ensemblId": "ENSG00000114209",
    "entrezId": 11235,
    "omim": [
      "609118"
    ],
    "uniprot": [
      "Q9BUL8"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "3",
      "start": 167683298,
      "end": 167734892,
      "strand": "-",
      "ensemblTranscript": "ENST00000392750.7",
      "refseqTranscript": "NM_007217.4",
      "ensemblProtein": "ENSP00000376506.2",
      "refseqProtein": "NP_009148.2",
      "exons": [
        {
          "start": 167683298,
          "end": 167684389
        },
        {
          "start": 167687234,
          "end": 167687316
        },
        {
          "start": 167687615,
          "end": 167687693
        },
        {
          "start": 167695596,
          "end": 167695722
        },
        {
          "start": 167697009,
          "end": 167697126
        },
        {
          "start": 167704842,
          "end": 167704895
        },
        {
          "start": 167720062,
          "end": 167720273
        },
        {
          "start": 167734214,
          "end": 167734350
        },
        {
          "start": 167734662,
          "end": 167734892
        }
      ],
      "cds": {
        "start": 167684308,
        "end": 167720157
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "3",
      "start": 167401086,
      "end": 167452727,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 167209095,
      "end": 168209094,
      "genes": [
        {
          "symbol": "ZBBX",
          "ensemblId": "ENSG00000169064",
          "biotype": "protein_coding",
          "start": 167239843,
          "end": 167407874,
          "strand": "-",
          "slug": "zbbx"
        },
        {
          "symbol": "SERPINI2",
          "ensemblId": "ENSG00000114204",
          "biotype": "protein_coding",
          "start": 167438967,
          "end": 167478972,
          "strand": "-",
          "slug": "serpini2"
        },
        {
          "symbol": "WDR49",
          "ensemblId": "ENSG00000174776",
          "biotype": "protein_coding",
          "start": 167477789,
          "end": 167653983,
          "strand": "-",
          "slug": "wdr49"
        },
        {
          "symbol": "SERPINI1",
          "ensemblId": "ENSG00000163536",
          "biotype": "protein_coding",
          "start": 167735065,
          "end": 167828461,
          "strand": "+",
          "slug": "serpini1"
        },
        {
          "symbol": "GOLIM4",
          "ensemblId": "ENSG00000173905",
          "biotype": "protein_coding",
          "start": 168008552,
          "end": 168096536,
          "strand": "-",
          "slug": "golim4"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "cerebral-cavernous-malformation",
        "name": "Kavernösa kärlmissbildningar i hjärnan (CCM)",
        "diseases": [
          {
            "mondoId": "MONDO:0011305",
            "name": "Cerebral Cavernous Malformation 3",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": "Varje familjär kavernös kärlmissbildning i hjärnan där sjukdomens orsak är en mutation i genen PDCD10.",
            "management": null,
            "evidence": {
              "gencc": [
                "G2P",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/sv/conditions/cerebral-cavernous-malformation"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "cerebral-calcification",
        "name": "Abnormal deposits of calcium in the brain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/cerebral-calcification"
      },
      {
        "slug": "abnormality-of-the-skin",
        "name": "Abnormality of the skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/abnormality-of-the-skin"
      },
      {
        "slug": "adrenal-calcification",
        "name": "Adrenal calcification",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/adrenal-calcification"
      },
      {
        "slug": "astrocytoma",
        "name": "Astrocytoma",
        "systems": [
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/astrocytoma"
      },
      {
        "slug": "cerebral-hemorrhage",
        "name": "Bleeding in brain",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cerebral-hemorrhage"
      },
      {
        "slug": "intracranial-hemorrhage",
        "name": "Bleeding within the skull",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/intracranial-hemorrhage"
      },
      {
        "slug": "cerebral-cavernous-malformation",
        "name": "Cerebral cavernous malformation",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/cerebral-cavernous-malformation"
      },
      {
        "slug": "choroidal-hemangioma",
        "name": "Choroidal hemangioma",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/choroidal-hemangioma"
      },
      {
        "slug": "cognitive-impairment",
        "name": "Cognitive impairment",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cognitive-impairment"
      },
      {
        "slug": "cavernous-hemangioma",
        "name": "Collection of dilated blood vessels that forms mass",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cavernous-hemangioma"
      },
      {
        "slug": "developmental-retinal-vascular-malformation",
        "name": "Developmental retinal vascular malformation",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/developmental-retinal-vascular-malformation"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "episodic-vomiting",
        "name": "Episodic vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/episodic-vomiting"
      },
      {
        "slug": "focal-t2-hyperintense-brainstem-lesion",
        "name": "Focal T2 hyperintense brainstem lesion",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/focal-t2-hyperintense-brainstem-lesion"
      },
      {
        "slug": "focal-t2-hypointense-brainstem-lesion",
        "name": "Focal T2 hypointense brainstem lesion",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/focal-t2-hypointense-brainstem-lesion"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "hepatic-vascular-malformations",
        "name": "Hepatic vascular malformations",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/hepatic-vascular-malformations"
      },
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      },
      {
        "slug": "abnormality-of-the-musculature",
        "name": "Muscular abnormality",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculature"
      },
      {
        "slug": "neuroma",
        "name": "Nerve tumor",
        "systems": [
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neuroma"
      },
      {
        "slug": "meningioma",
        "name": "Noncancerous growth of membranes covering brain",
        "systems": [
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/meningioma"
      },
      {
        "slug": "hypoesthesia",
        "name": "Numbness",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypoesthesia"
      },
      {
        "slug": "paralysis",
        "name": "Paralysis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/paralysis"
      },
      {
        "slug": "paresthesia",
        "name": "Pins and needles feeling",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/paresthesia"
      },
      {
        "slug": "retinal-cavernous-hemangioma",
        "name": "Retinal cavernous hemangioma",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/retinal-cavernous-hemangioma"
      },
      {
        "slug": "increased-intracranial-pressure",
        "name": "Rise in pressure inside skull",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-intracranial-pressure"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "spinal-cord-lesion",
        "name": "Spinal cord lesion",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/spinal-cord-lesion"
      },
      {
        "slug": "hemangioma",
        "name": "Strawberry mark",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hemangioma"
      },
      {
        "slug": "vascular-skin-abnormality",
        "name": "Vascular skin abnormality",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/vascular-skin-abnormality"
      },
      {
        "slug": "venous-malformation",
        "name": "Venous malformation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/venous-malformation"
      },
      {
        "slug": "vestibular-schwannoma",
        "name": "Vestibular schwannoma",
        "systems": [
          "abnormality-of-the-ear",
          "abnormality-of-the-nervous-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/vestibular-schwannoma"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}