{
  "url": "https://dantelabs.com/sv/genes/kpna7",
  "gene": {
    "slug": "kpna7",
    "symbol": "KPNA7",
    "name": "karyopherin subunit alpha 7",
    "hgnc": "HGNC:21839",
    "summary": null,
    "location": "7q22.1",
    "locusType": "gene with protein product",
    "aliases": [
      "IPOA8"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000185467",
    "entrezId": 402569,
    "omim": [
      "614107"
    ],
    "uniprot": [
      "A9QM74"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "7",
      "start": 99173572,
      "end": 99208115,
      "strand": "-",
      "ensemblTranscript": "ENST00000327442.7",
      "refseqTranscript": "NM_001145715.3",
      "ensemblProtein": "ENSP00000330878.6",
      "refseqProtein": "NP_001139187.1",
      "exons": [
        {
          "start": 99173572,
          "end": 99173794
        },
        {
          "start": 99177920,
          "end": 99178066
        },
        {
          "start": 99181883,
          "end": 99182065
        },
        {
          "start": 99184929,
          "end": 99185162
        },
        {
          "start": 99188300,
          "end": 99188563
        },
        {
          "start": 99193019,
          "end": 99193101
        },
        {
          "start": 99195070,
          "end": 99195338
        },
        {
          "start": 99196084,
          "end": 99196166
        },
        {
          "start": 99203106,
          "end": 99203240
        },
        {
          "start": 99207401,
          "end": 99207489
        },
        {
          "start": 99208028,
          "end": 99208115
        }
      ],
      "cds": {
        "start": 99173708,
        "end": 99207466
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "7",
      "start": 98771197,
      "end": 98805129,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 98690844,
      "end": 99690843,
      "genes": [
        {
          "symbol": "TMEM130",
          "ensemblId": "ENSG00000166448",
          "biotype": "protein_coding",
          "start": 98846478,
          "end": 98870771,
          "strand": "-",
          "slug": "tmem130"
        },
        {
          "symbol": "TRRAP",
          "ensemblId": "ENSG00000196367",
          "biotype": "protein_coding",
          "start": 98877933,
          "end": 99050831,
          "strand": "+",
          "slug": "trrap"
        },
        {
          "symbol": "SMURF1",
          "ensemblId": "ENSG00000198742",
          "biotype": "protein_coding",
          "start": 99027435,
          "end": 99144171,
          "strand": "-",
          "slug": "smurf1"
        },
        {
          "symbol": "MYH16",
          "ensemblId": "ENSG00000293560",
          "biotype": "protein_coding",
          "start": 99272839,
          "end": 99311132,
          "strand": "+",
          "slug": "myh16"
        },
        {
          "symbol": "ARPC1A",
          "ensemblId": "ENSG00000241685",
          "biotype": "protein_coding",
          "start": 99325879,
          "end": 99366527,
          "strand": "+",
          "slug": "arpc1a"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000284292",
          "biotype": "protein_coding",
          "start": 99325879,
          "end": 99394653,
          "strand": "+"
        },
        {
          "symbol": "ARPC1B",
          "ensemblId": "ENSG00000130429",
          "biotype": "protein_coding",
          "start": 99374226,
          "end": 99398124,
          "strand": "+",
          "slug": "arpc1b"
        },
        {
          "symbol": "PDAP1",
          "ensemblId": "ENSG00000106244",
          "biotype": "protein_coding",
          "start": 99392048,
          "end": 99408831,
          "strand": "-",
          "slug": "pdap1"
        },
        {
          "symbol": "BUD31",
          "ensemblId": "ENSG00000106245",
          "biotype": "protein_coding",
          "start": 99408610,
          "end": 99419618,
          "strand": "+",
          "slug": "bud31"
        },
        {
          "symbol": "PTCD1",
          "ensemblId": "ENSG00000106246",
          "biotype": "protein_coding",
          "start": 99415192,
          "end": 99466201,
          "strand": "-",
          "slug": "ptcd1"
        },
        {
          "symbol": "ATP5MF-PTCD1",
          "ensemblId": "ENSG00000248919",
          "biotype": "protein_coding",
          "start": 99419749,
          "end": 99466197,
          "strand": "-",
          "slug": "atp5mf-ptcd1"
        },
        {
          "symbol": "CPSF4",
          "ensemblId": "ENSG00000160917",
          "biotype": "protein_coding",
          "start": 99438908,
          "end": 99458910,
          "strand": "+",
          "slug": "cpsf4"
        },
        {
          "symbol": "ATP5MF",
          "ensemblId": "ENSG00000241468",
          "biotype": "protein_coding",
          "start": 99448475,
          "end": 99466201,
          "strand": "-",
          "slug": "atp5mf"
        },
        {
          "symbol": "ZNF789",
          "ensemblId": "ENSG00000198556",
          "biotype": "protein_coding",
          "start": 99472794,
          "end": 99503650,
          "strand": "+",
          "slug": "znf789"
        },
        {
          "symbol": "ZNF394",
          "ensemblId": "ENSG00000160908",
          "biotype": "protein_coding",
          "start": 99473877,
          "end": 99504918,
          "strand": "-",
          "slug": "znf394"
        },
        {
          "symbol": "ZKSCAN5",
          "ensemblId": "ENSG00000196652",
          "biotype": "protein_coding",
          "start": 99504634,
          "end": 99535360,
          "strand": "+",
          "slug": "zkscan5"
        },
        {
          "symbol": "ZBED8L",
          "ensemblId": "ENSG00000221909",
          "biotype": "protein_coding",
          "start": 99546204,
          "end": 99559392,
          "strand": "-",
          "slug": "zbed8l"
        },
        {
          "symbol": "ZNF655",
          "ensemblId": "ENSG00000197343",
          "biotype": "protein_coding",
          "start": 99558389,
          "end": 99578948,
          "strand": "+",
          "slug": "znf655"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000272647",
          "biotype": "protein_coding",
          "start": 99558695,
          "end": 99607810,
          "strand": "+"
        },
        {
          "symbol": "TMEM225B",
          "ensemblId": "ENSG00000244219",
          "biotype": "protein_coding",
          "start": 99597868,
          "end": 99611045,
          "strand": "+",
          "slug": "tmem225b"
        },
        {
          "symbol": "ZSCAN25",
          "ensemblId": "ENSG00000197037",
          "biotype": "protein_coding",
          "start": 99616623,
          "end": 99738531,
          "strand": "+",
          "slug": "zscan25"
        },
        {
          "symbol": "CYP3A5",
          "ensemblId": "ENSG00000106258",
          "biotype": "protein_coding",
          "start": 99647442,
          "end": 99680043,
          "strand": "-",
          "slug": "cyp3a5"
        },
        {
          "symbol": "CYP3A7-CYP3A51P",
          "ensemblId": "ENSG00000282301",
          "biotype": "protein_coding",
          "start": 99684957,
          "end": 99735102,
          "strand": "-",
          "slug": "cyp3a7-cyp3a51p"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "female-infertility",
        "name": "Kvinnlig infertilitet",
        "diseases": [
          {
            "mondoId": "MONDO:0014769",
            "name": "ärftlig defekt i oocytmognaden",
            "genes": 17,
            "inheritance": null,
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/sv/conditions/female-infertility"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-meiosis",
        "name": "Abnormal meiosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-meiosis"
      },
      {
        "slug": "abnormal-oocyte-morphology",
        "name": "Abnormal oocyte morphology",
        "systems": [
          "abnormal-cellular-phenotype"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-oocyte-morphology"
      },
      {
        "slug": "abnormal-spermatogenesis",
        "name": "Abnormal sperm development",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-spermatogenesis"
      },
      {
        "slug": "female-infertility",
        "name": "Female infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/female-infertility"
      },
      {
        "slug": "metaphase-i-oocyte-maturation-arrest",
        "name": "Metaphase I oocyte maturation arrest",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/metaphase-i-oocyte-maturation-arrest"
      },
      {
        "slug": "polycystic-ovaries",
        "name": "Polycystic ovaries",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/polycystic-ovaries"
      }
    ],
    "related": [
      {
        "slug": "btg4",
        "symbol": "BTG4",
        "name": "BTG anti-proliferation factor 4",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/btg4"
      },
      {
        "slug": "cdc20",
        "symbol": "CDC20",
        "name": "cell division cycle 20",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/cdc20"
      },
      {
        "slug": "mos",
        "symbol": "MOS",
        "name": "MOS proto-oncogene, serine/threonine kinase",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/mos"
      },
      {
        "slug": "nlrp2",
        "symbol": "NLRP2",
        "name": "NLR family pyrin domain containing 2",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/nlrp2"
      },
      {
        "slug": "nlrp5",
        "symbol": "NLRP5",
        "name": "NLR family pyrin domain containing 5",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/nlrp5"
      },
      {
        "slug": "padi6",
        "symbol": "PADI6",
        "name": "peptidyl arginine deiminase 6",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/padi6"
      },
      {
        "slug": "panx1",
        "symbol": "PANX1",
        "name": "pannexin 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/panx1"
      },
      {
        "slug": "patl2",
        "symbol": "PATL2",
        "name": "PAT1 homolog 2",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/patl2"
      },
      {
        "slug": "rec114",
        "symbol": "REC114",
        "name": "REC114 meiotic recombination protein",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/rec114"
      },
      {
        "slug": "trip13",
        "symbol": "TRIP13",
        "name": "thyroid hormone receptor interactor 13",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/trip13"
      },
      {
        "slug": "tuba4a",
        "symbol": "TUBA4A",
        "name": "tubulin alpha 4a",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/tuba4a"
      },
      {
        "slug": "tubb8",
        "symbol": "TUBB8",
        "name": "tubulin beta 8 class VIII",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/tubb8"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}