{
  "url": "https://dantelabs.com/sv/genes/hoxb1",
  "gene": {
    "slug": "hoxb1",
    "symbol": "HOXB1",
    "name": "homeobox B1",
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    "summary": null,
    "location": "17q21.32",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
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      "HOX2I"
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    "ensemblId": "ENSG00000120094",
    "entrezId": 3211,
    "omim": [
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    "uniprot": [
      "P14653"
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    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "17",
      "start": 48528526,
      "end": 48531011,
      "strand": "-",
      "ensemblTranscript": "ENST00000239174.7",
      "refseqTranscript": "NM_002144.4",
      "ensemblProtein": "ENSP00000355140.5",
      "refseqProtein": "NP_002135.2",
      "exons": [
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          "end": 48529875
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        {
          "start": 48530328,
          "end": 48531011
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      ],
      "cds": {
        "start": 48529547,
        "end": 48530904
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    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "17",
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      "end": 46608359,
      "strand": "-"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "COPZ2",
          "ensemblId": "ENSG00000005243",
          "biotype": "protein_coding",
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          "end": 48038030,
          "strand": "-",
          "slug": "copz2"
        },
        {
          "symbol": "NFE2L1",
          "ensemblId": "ENSG00000082641",
          "biotype": "protein_coding",
          "start": 48047889,
          "end": 48088647,
          "strand": "+",
          "slug": "nfe2l1"
        },
        {
          "symbol": "CBX1",
          "ensemblId": "ENSG00000108468",
          "biotype": "protein_coding",
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          "end": 48107848,
          "strand": "-",
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        {
          "symbol": "SNX11",
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          "strand": "+",
          "slug": "snx11"
        },
        {
          "symbol": "SKAP1",
          "ensemblId": "ENSG00000141293",
          "biotype": "protein_coding",
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          "end": 48430275,
          "strand": "-",
          "slug": "skap1"
        },
        {
          "symbol": "HOXB2",
          "ensemblId": "ENSG00000173917",
          "biotype": "protein_coding",
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          "slug": "hoxb2"
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        {
          "symbol": "HOXB3",
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          "slug": "hoxb3"
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        {
          "symbol": "HOXB4",
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          "biotype": "protein_coding",
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          "end": 48578429,
          "strand": "-",
          "slug": "hoxb4"
        },
        {
          "symbol": "HOXB5",
          "ensemblId": "ENSG00000120075",
          "biotype": "protein_coding",
          "start": 48591257,
          "end": 48594179,
          "strand": "-",
          "slug": "hoxb5"
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        {
          "symbol": "HOXB6",
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          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "hoxb6"
        },
        {
          "symbol": "HOXB7",
          "ensemblId": "ENSG00000260027",
          "biotype": "protein_coding",
          "start": 48607222,
          "end": 48633572,
          "strand": "-",
          "slug": "hoxb7"
        },
        {
          "symbol": "HOXB8",
          "ensemblId": "ENSG00000120068",
          "biotype": "protein_coding",
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          "end": 48618003,
          "strand": "-",
          "slug": "hoxb8"
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        {
          "symbol": "HOXB9",
          "ensemblId": "ENSG00000170689",
          "biotype": "protein_coding",
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          "end": 48626576,
          "strand": "-",
          "slug": "hoxb9"
        },
        {
          "symbol": "PRAC2",
          "ensemblId": "ENSG00000229637",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "prac2"
        },
        {
          "symbol": "PRAC1",
          "ensemblId": "ENSG00000159182",
          "biotype": "protein_coding",
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          "end": 48723082,
          "strand": "-",
          "slug": "prac1"
        },
        {
          "symbol": "HOXB13",
          "ensemblId": "ENSG00000159184",
          "biotype": "protein_coding",
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          "end": 48729076,
          "strand": "-",
          "slug": "hoxb13"
        },
        {
          "symbol": "TTLL6",
          "ensemblId": "ENSG00000170703",
          "biotype": "protein_coding",
          "start": 48762234,
          "end": 48817229,
          "strand": "-",
          "slug": "ttll6"
        },
        {
          "symbol": "CALCOCO2",
          "ensemblId": "ENSG00000136436",
          "biotype": "protein_coding",
          "start": 48830971,
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          "strand": "+",
          "slug": "calcoco2"
        },
        {
          "symbol": "ATP5MC1",
          "ensemblId": "ENSG00000159199",
          "biotype": "protein_coding",
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          "end": 48895875,
          "strand": "+",
          "slug": "atp5mc1"
        },
        {
          "symbol": "UBE2Z",
          "ensemblId": "ENSG00000159202",
          "biotype": "protein_coding",
          "start": 48908368,
          "end": 48929062,
          "strand": "+",
          "slug": "ube2z"
        },
        {
          "symbol": "SNF8",
          "ensemblId": "ENSG00000159210",
          "biotype": "protein_coding",
          "start": 48928972,
          "end": 48944842,
          "strand": "-",
          "slug": "snf8"
        },
        {
          "symbol": "GIP",
          "ensemblId": "ENSG00000159224",
          "biotype": "protein_coding",
          "start": 48958554,
          "end": 48968596,
          "strand": "-",
          "slug": "gip"
        },
        {
          "symbol": "IGF2BP1",
          "ensemblId": "ENSG00000159217",
          "biotype": "protein_coding",
          "start": 48997225,
          "end": 49056148,
          "strand": "+",
          "slug": "igf2bp1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "facial-palsy",
        "name": "Bell's palsy",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/facial-palsy"
      },
      {
        "slug": "broad-forehead",
        "name": "Broad forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/broad-forehead"
      },
      {
        "slug": "impaired-mastication",
        "name": "Chewing difficulties",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/impaired-mastication"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "depressed-nasal-bridge",
        "name": "Depressed nasal bridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/depressed-nasal-bridge"
      },
      {
        "slug": "dysarthria",
        "name": "Difficulty articulating speech",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/dysarthria"
      },
      {
        "slug": "downturned-corners-of-mouth",
        "name": "Downturned corners of mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/downturned-corners-of-mouth"
      },
      {
        "slug": "unilateral-ptosis",
        "name": "Dropping of one upper eyelid",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/unilateral-ptosis"
      },
      {
        "slug": "posteriorly-rotated-ears",
        "name": "Ears rotated toward back of head",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/posteriorly-rotated-ears"
      },
      {
        "slug": "esophoria",
        "name": "Esophoria",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/esophoria"
      },
      {
        "slug": "epicanthus",
        "name": "Eye folds",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/epicanthus"
      },
      {
        "slug": "lagophthalmos",
        "name": "Eyelids stay open",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/lagophthalmos"
      },
      {
        "slug": "feeding-difficulties",
        "name": "Feeding difficulties",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/feeding-difficulties"
      },
      {
        "slug": "high-palate",
        "name": "High palate",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/high-palate"
      },
      {
        "slug": "esotropia",
        "name": "Inward turning cross eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/esotropia"
      },
      {
        "slug": "micrognathia",
        "name": "Little lower jaw",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/micrognathia"
      },
      {
        "slug": "low-set-ears",
        "name": "Low-set ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/low-set-ears"
      },
      {
        "slug": "midface-retrusion",
        "name": "Midface retrusion",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/midface-retrusion"
      },
      {
        "slug": "myopathic-facies",
        "name": "Myopathic facies",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/myopathic-facies"
      },
      {
        "slug": "anteverted-nares",
        "name": "Nasal tip, upturned",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anteverted-nares"
      },
      {
        "slug": "open-mouth",
        "name": "Open mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/open-mouth"
      },
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "short-nose",
        "name": "Short nose",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-nose"
      },
      {
        "slug": "short-philtrum",
        "name": "Short philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/short-philtrum"
      },
      {
        "slug": "smooth-philtrum",
        "name": "Smooth philtrum",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/smooth-philtrum"
      },
      {
        "slug": "tented-upper-lip-vermilion",
        "name": "Tented mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/tented-upper-lip-vermilion"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}