{ "url": "https://dantelabs.com/sv/genes/gck", "gene": { "slug": "gck", "symbol": "GCK", "name": "glucokinase", "hgnc": "HGNC:4195", "summary": null, "location": "7p13", "locusType": "gene with protein product", "aliases": [ "HK4", "HKIV" ], "previousSymbols": [ "MODY2" ], "ensemblId": "ENSG00000106633", "entrezId": 2645, "omim": [ "138079" ], "uniprot": [ "P35557" ], "model": { "build": "GRCh38", "release": "v1.5", "chrom": "7", "start": 44144275, "end": 44189439, "strand": "-", "ensemblTranscript": "ENST00000403799.8", "refseqTranscript": "NM_000162.5", "ensemblProtein": "ENSP00000384247.3", "refseqProtein": "NP_000153.1", "exons": [ { "start": 44144275, "end": 44145280 }, { "start": 44145497, "end": 44145730 }, { "start": 44146463, "end": 44146618 }, { "start": 44147650, "end": 44147833 }, { "start": 44149760, "end": 44149859 }, { "start": 44149969, "end": 44150064 }, { "start": 44150956, "end": 44151075 }, { "start": 44152271, "end": 44152425 }, { "start": 44153301, "end": 44153463 }, { "start": 44188909, "end": 44189439 } ], "cds": { "start": 44145136, "end": 44188953 } }, "grch37": { "build": "GRCh37", "release": "87", "chrom": "7", "start": 44183872, "end": 44237769, "strand": "-" }, "neighbourhood": { "release": "116", "start": 43666857, "end": 44666856, "genes": [ { "symbol": "COA1", "ensemblId": "ENSG00000106603", "biotype": "protein_coding", "start": 43552389, "end": 43729857, "strand": "-", "slug": "coa1" }, { "symbol": "BLVRA", "ensemblId": "ENSG00000106605", "biotype": "protein_coding", "start": 43758009, "end": 43808868, "strand": "+", "slug": "blvra" }, { "symbol": "MRPS24", "ensemblId": "ENSG00000062582", "biotype": "protein_coding", "start": 43866556, "end": 43869893, "strand": "-", "slug": "mrps24" }, { "symbol": "URGCP-MRPS24", "ensemblId": "ENSG00000270617", "biotype": "protein_coding", "start": 43866558, "end": 43906589, "strand": "-", "slug": "urgcp-mrps24" }, { "symbol": "URGCP", "ensemblId": "ENSG00000106608", "biotype": "protein_coding", "start": 43873645, "end": 43926411, "strand": "-", "slug": "urgcp" }, { "symbol": "UBE2D4", "ensemblId": "ENSG00000078967", "biotype": "protein_coding", "start": 43925799, "end": 43956136, "strand": "+", "slug": "ube2d4" }, { "symbol": "SPDYE1", "ensemblId": "ENSG00000136206", "biotype": "protein_coding", "start": 43997897, "end": 44010124, "strand": "+", "slug": "spdye1" }, { "symbol": "DBNL", "ensemblId": "ENSG00000136279", "biotype": "protein_coding", "start": 44044628, "end": 44069456, "strand": "+", "slug": "dbnl" }, { "symbol": "PGAM2", "ensemblId": "ENSG00000164708", "biotype": "protein_coding", "start": 44062724, "end": 44065736, "strand": "-", "slug": "pgam2" }, { "symbol": "POLM", "ensemblId": "ENSG00000122678", "biotype": "protein_coding", "start": 44070915, "end": 44082985, "strand": "-", "slug": "polm" }, { "symbol": "AEBP1", "ensemblId": "ENSG00000106624", "biotype": "protein_coding", "start": 44104286, "end": 44114565, "strand": "+", "slug": "aebp1" }, { "symbol": "POLD2", "ensemblId": "ENSG00000106628", "biotype": "protein_coding", "start": 44114631, "end": 44124407, "strand": "-", "slug": "pold2" }, { "symbol": "MYL7", "ensemblId": "ENSG00000106631", "biotype": "protein_coding", "start": 44138857, "end": 44143179, "strand": "-", "slug": "myl7" }, { "symbol": "YKT6", "ensemblId": "ENSG00000106636", "biotype": "protein_coding", "start": 44200959, "end": 44214294, "strand": "+", "slug": "ykt6" }, { "symbol": "CAMK2B", "ensemblId": "ENSG00000058404", "biotype": "protein_coding", "start": 44209993, "end": 44334577, "strand": "-", "slug": "camk2b" }, { "symbol": "NUDCD3", "ensemblId": "ENSG00000015676", "biotype": "protein_coding", "start": 44379119, "end": 44490919, "strand": "-", "slug": "nudcd3" }, { "symbol": "NPC1L1", "ensemblId": "ENSG00000015520", "biotype": "protein_coding", "start": 44512442, "end": 44541330, "strand": "-", "slug": "npc1l1" }, { "symbol": "DDX56", "ensemblId": "ENSG00000136271", "biotype": "protein_coding", "start": 44565416, "end": 44575388, "strand": "-", "slug": "ddx56" }, { "symbol": "TMED4", "ensemblId": "ENSG00000158604", "biotype": "protein_coding", "start": 44576392, "end": 44582309, "strand": "-", "slug": "tmed4" }, { "symbol": "OGDH", "ensemblId": "ENSG00000105953", "biotype": "protein_coding", "start": 44606496, "end": 44710116, "strand": "+", "slug": "ogdh" } ], "truncated": false }, "reports": [ { "slug": "diabetes-mellitus", "name": "Diabetes mellitus", "diseases": [ { "mondoId": "MONDO:0005015", "name": "Diabetes mellitus", "genes": 31, "inheritance": null, "description": "En ämnesomsättningsrubbning som kännetecknas av onormalt höga blodsockernivåer på grund av minskad insulinproduktion eller insulinresistens/desensibilisering.", "management": "Teplizumab (Tzield) vid presymptomatisk typ 1-diabetes steg 2 (FDA-godkänd 2022); insulinersättning vid klinisk debut av typ 1-diabetes; TrialNet-screening för autoantikroppar hos släktingar med hög risk; slutna system för automatisk insulinleverans", "evidence": { "gencc": [ "Ambry Genetics", "ClinGen", "Genomics England PanelApp", "Labcorp Genetics (formerly Invitae)", "PanelApp Australia" ], "clingen": "Definitive", "acmgSf": false, "inheritance": [ "autosomal-dominant", "autosomal-recessive" ] }, "sameAsReport": true, "broad": false } ], "url": "https://dantelabs.com/sv/conditions/diabetes-mellitus" }, { "slug": "hyperinsulinism", "name": "Hyperinsulinism", "diseases": [ { "mondoId": "MONDO:0007834", "name": "Islet Cell Adenomatosis", "genes": 5, "inheritance": "autosomal-dominant", "description": "En sporadisk eller ärftlig sjukdom som kännetecknas av fokal eller diffus proliferation av cellerna i Langerhans öar i bukspottkörteln. Den leder till hyperinsulinemi och hypoglykemi.", "management": null, "evidence": { "gencc": [ "Ambry Genetics", "ClinGen", "Genomics England PanelApp", "Labcorp Genetics (formerly Invitae)", "PanelApp Australia" ], "clingen": "Definitive", "acmgSf": false, "inheritance": [ "autosomal-dominant" ] }, "sameAsReport": false, "broad": false }, { "mondoId": "MONDO:0002177", "name": "Hyperinsulinism", "genes": 9, "inheritance": null, "description": "Onormalt höga nivåer av insulin i blodet.", "management": null, "evidence": { "gencc": [ "Ambry Genetics", "ClinGen", "Genomics England PanelApp", "Labcorp Genetics (formerly Invitae)", "PanelApp Australia" ], "clingen": "Definitive", "acmgSf": false, "inheritance": [ "autosomal-dominant" ] }, "sameAsReport": true, "broad": false } ], "url": "https://dantelabs.com/sv/conditions/hyperinsulinism" }, { "slug": "maturity-onset-diabetes-of-the-young", "name": "Maturity-Onset Diabetes Of The Young", "diseases": [ { "mondoId": "MONDO:0018911", "name": "Maturity-Onset Diabetes Of The Young", "genes": 12, "inheritance": "autosomal-dominant", "description": "MODY (Maturity-Onset Diabetes of the Young) är en sällsynt, familjärt förekommande, klinisk och genetiskt heterogen form av diabetes. Den kännetecknas av debut vid ung ålder (generellt 10–45 år) med bibehållen egen insulinproduktion, avsaknad av autoimmunitet mot betaceller i bukspottkörteln, ingen fetma och ingen insulinresistens samt, vid vissa undertyper, manifestationer utanför bukspottkörteln.", "management": "GCK-MODY: ingen behandling behövs; HNF1A/HNF4A-MODY: sulfonylureider i låg dos; HNF1B-MODY: insulin + njuruppföljning; T2D polygen: livsstilsförändring, metformin, GLP-1-agonister och SGLT2-hämmare utifrån profilen av samsjuklighet", "evidence": { "gencc": [ "Ambry Genetics", "Genomics England PanelApp", "Labcorp Genetics (formerly Invitae)", "PanelApp Australia" ], "acmgSf": false, "inheritance": [ "autosomal-dominant" ] }, "sameAsReport": true, "broad": false } ], "url": "https://dantelabs.com/sv/conditions/maturity-onset-diabetes-of-the-young" }, { "slug": "neonatal-diabetes-mellitus", "name": "Neonatal diabetes mellitus", "diseases": [ { "mondoId": "MONDO:0016391", "name": "Neonatal diabetes mellitus", "genes": 20, "inheritance": null, "description": "Diabetes som upptäcks under de första månaderna av livet, antingen permanent eller övergående, orsakad av defekter i en enskild gen som påverkar insulinproduktion eller insulinutsöndring.", "management": "De flesta med neonatal diabetes orsakad av KCNJ11 eller ABCC8 kan byta från insulininjektioner till sulfonylureatabletter, ofta med bättre blodsockerkontroll.", "evidence": { "gencc": [ "Genomics England PanelApp", "Labcorp Genetics (formerly Invitae)", "PanelApp Australia" ], "acmgSf": false, "inheritance": [ "autosomal-recessive" ] }, "sameAsReport": true, "broad": false } ], "url": "https://dantelabs.com/sv/conditions/neonatal-diabetes-mellitus" } ], "pharmacogenomics": [], "traits": [], "phenotypes": [ { "slug": "abnormal-circulating-c-peptide-concentration", "name": "Abnormal circulating C-peptide concentration", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/abnormal-circulating-c-peptide-concentration" }, { "slug": "abnormal-circulating-insulin-concentration", "name": "Abnormal circulating insulin concentration", "systems": [ "abnormality-of-the-endocrine-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/abnormal-circulating-insulin-concentration" }, { "slug": "renal-tubular-dysfunction", "name": "Abnormal function of filtrating structures in kidney", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/renal-tubular-dysfunction" }, { "slug": "abnormal-nervous-system-physiology", "name": "Abnormal nervous system physiology", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/abnormal-nervous-system-physiology" }, { "slug": "abnormal-oral-glucose-tolerance", "name": "Abnormal oral glucose tolerance", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/abnormal-oral-glucose-tolerance" }, { "slug": "abnormality-of-the-autonomic-nervous-system", "name": "Abnormality of the autonomic nervous system", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/abnormality-of-the-autonomic-nervous-system" }, { "slug": "abnormality-of-the-genitourinary-system", "name": "Abnormality of the genitourinary system", "systems": [], "frequency": "very-rare", "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system" }, { "slug": "abnormal-heart-morphology", "name": "Abnormality of the heart", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/abnormal-heart-morphology" }, { "slug": "abnormality-of-the-kidney", "name": "Abnormality of the kidney", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/abnormality-of-the-kidney" }, { "slug": "abnormality-of-the-upper-urinary-tract", "name": "Abnormality of the upper urinary tract", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormality-of-the-upper-urinary-tract" }, { "slug": "apraxia", "name": "Apraxia", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/apraxia" }, { "slug": "arthrogryposis-multiplex-congenita", "name": "Arthrogryposis multiplex congenita", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/arthrogryposis-multiplex-congenita" }, { "slug": "ataxia", "name": "Ataxia", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/ataxia" }, { "slug": "autoimmune-antibody-positivity", "name": "Autoimmune antibody positivity", "systems": [ "abnormality-of-the-immune-system" ], "url": "https://dantelabs.com/traits/autoimmune-antibody-positivity" }, { "slug": "large-for-gestational-age", "name": "Birth weight > 90th percentile", "systems": [ "growth-abnormality" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/large-for-gestational-age" }, { "slug": "insulin-resistance", "name": "Body fails to respond to insulin", "systems": [ "abnormality-of-metabolism-homeostasis" ], "url": "https://dantelabs.com/traits/insulin-resistance" }, { "slug": "coma", "name": "Coma", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/coma" }, { "slug": "hypoglycemic-coma", "name": "Coma caused by low blood sugar", "systems": [ "abnormality-of-the-nervous-system" ], "url": "https://dantelabs.com/traits/hypoglycemic-coma" }, { "slug": "renal-cyst", "name": "Cystic kidney disease", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/renal-cyst" }, { "slug": "acanthosis-nigricans", "name": "Darkened and thickened skin", "systems": [ "abnormality-of-the-integument" ], "url": "https://dantelabs.com/traits/acanthosis-nigricans" }, { "slug": "decreased-circulating-c-peptide-concentration", "name": "Decreased circulating C-peptide concentration", "systems": [ "abnormality-of-metabolism-homeostasis" ], "url": "https://dantelabs.com/traits/decreased-circulating-c-peptide-concentration" }, { "slug": "dehydration", "name": "Dehydration", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/dehydration" }, { "slug": "hypovolemia", "name": "Depleted blood volume", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/hypovolemia" }, { "slug": "diabetes-mellitus", "name": "Diabetes mellitus", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/diabetes-mellitus" }, { "slug": "diabetic-ketoacidosis", "name": "Diabetic ketoacidosis", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "url": "https://dantelabs.com/traits/diabetic-ketoacidosis" }, { "slug": "downturned-corners-of-mouth", "name": "Downturned corners of mouth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/downturned-corners-of-mouth" }, { "slug": "bilateral-ptosis", "name": "Drooping of both upper eyelids", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/bilateral-ptosis" }, { "slug": "elevated-hemoglobin-a1c", "name": "Elevated hemoglobin A1c", "systems": [ "abnormality-of-blood-and-blood-forming-tissues" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/elevated-hemoglobin-a1c" }, { "slug": "seizure", "name": "Epilepsy", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/seizure" }, { "slug": "failure-to-thrive", "name": "Faltering weight", "systems": [ "growth-abnormality" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/failure-to-thrive" }, { "slug": "fatigue", "name": "Fatigue", "systems": [ "constitutional-symptom" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/fatigue" }, { "slug": "generalized-myoclonic-seizure", "name": "Generalized myoclonic seizure", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/generalized-myoclonic-seizure" }, { "slug": "global-developmental-delay", "name": "Global developmental delay", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/global-developmental-delay" }, { "slug": "glycosuria", "name": "Glucose in urine", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-genitourinary-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/glycosuria" }, { "slug": "glucose-intolerance", "name": "Glucose intolerance", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/glucose-intolerance" }, { "slug": "bilateral-tonic-clonic-seizure", "name": "Grand mal seizures", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/bilateral-tonic-clonic-seizure" }, { "slug": "hand-tremor", "name": "Hand tremor", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/hand-tremor" }, { "slug": "hearing-impairment", "name": "Hearing impairment", "systems": [ "abnormality-of-the-ear" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/hearing-impairment" }, { "slug": "hepatocellular-adenoma", "name": "Hepatocellular adenoma", "systems": [ "abnormality-of-the-digestive-system", "neoplasm" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/hepatocellular-adenoma" }, { "slug": "fasting-hyperinsulinemia", "name": "High blood insulin levels while fasting", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/fasting-hyperinsulinemia" }, { "slug": "hyperglycemia", "name": "High blood sugar", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/hyperglycemia" }, { "slug": "moderate-albuminuria", "name": "High urine albumin levels", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-genitourinary-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/moderate-albuminuria" }, { "slug": "hyperinsulinemic-hypoglycemia", "name": "Hyperinsulinemic hypoglycemia", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/hyperinsulinemic-hypoglycemia" }, { "slug": "hypoglycemic-seizures", "name": "Hypoglycemic seizures", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/hypoglycemic-seizures" }, { "slug": "hypoinsulinemia", "name": "Hypoinsulinemia", "systems": [ "abnormality-of-the-endocrine-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/hypoinsulinemia" }, { "slug": "hypoketotic-hypoglycemia", "name": "Hypoketotic hypoglycemia", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/hypoketotic-hypoglycemia" }, { "slug": "exocrine-pancreatic-insufficiency", "name": "Inability to properly digest food due to lack of pancreatic digestive enzymes", "systems": [ "abnormality-of-the-digestive-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/exocrine-pancreatic-insufficiency" }, { "slug": "increased-waist-to-hip-ratio", "name": "Increased waist to hip ratio", "systems": [ "growth-abnormality" ], "url": "https://dantelabs.com/traits/increased-waist-to-hip-ratio" }, { "slug": "insulin-resistant-diabetes-mellitus", "name": "Insulin resistant diabetes", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/insulin-resistant-diabetes-mellitus" }, { "slug": "intellectual-disability", "name": "Intellectual disability", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/intellectual-disability" }, { "slug": "severe-intellectual-disability", "name": "Intellectual disability, severe", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/severe-intellectual-disability" }, { "slug": "ketonuria", "name": "Ketonuria", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-genitourinary-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/ketonuria" }, { "slug": "nephropathy", "name": "Kidney damage", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/nephropathy" }, { "slug": "neonatal-hypoglycemia", "name": "Low blood sugar in newborn", "systems": [ "abnormality-of-metabolism-homeostasis" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/neonatal-hypoglycemia" }, { "slug": "hypotonia", "name": "Low muscle tone", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/hypotonia" }, { "slug": "lower-limb-joint-contracture", "name": "Lower-limb joint contracture", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/lower-limb-joint-contracture" }, { "slug": "maturity-onset-diabetes-of-the-young", "name": "Maturity-onset diabetes of the young", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/maturity-onset-diabetes-of-the-young" }, { "slug": "motor-delay", "name": "Motor delay", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/motor-delay" }, { "slug": "muscle-weakness", "name": "Muscle weakness", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/muscle-weakness" }, { "slug": "neonatal-insulin-dependent-diabetes-mellitus", "name": "Neonatal insulin-dependent diabetes mellitus", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/neonatal-insulin-dependent-diabetes-mellitus" }, { "slug": "neurodevelopmental-delay", "name": "Neurodevelopmental delay", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/neurodevelopmental-delay" }, { "slug": "retinopathy", "name": "Noninflammatory retina disease", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/retinopathy" }, { "slug": "type-ii-diabetes-mellitus", "name": "Noninsulin-dependent diabetes", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/type-ii-diabetes-mellitus" }, { "slug": 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