{
  "url": "https://dantelabs.com/sv/genes/fuz",
  "gene": {
    "slug": "fuz",
    "symbol": "FUZ",
    "name": "fuzzy planar cell polarity protein",
    "hgnc": "HGNC:26219",
    "summary": null,
    "location": "19q13.33",
    "locusType": "gene with protein product",
    "aliases": [
      "FLJ22688",
      "Fy",
      "CPLANE3"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000010361",
    "entrezId": 80199,
    "omim": [
      "610622"
    ],
    "uniprot": [
      "Q9BT04"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "19",
      "start": 49806866,
      "end": 49813292,
      "strand": "-",
      "ensemblTranscript": "ENST00000313777.9",
      "refseqTranscript": "NM_025129.5",
      "ensemblProtein": "ENSP00000313309.4",
      "refseqProtein": "NP_079405.2",
      "exons": [
        {
          "start": 49806866,
          "end": 49807374
        },
        {
          "start": 49808414,
          "end": 49808488
        },
        {
          "start": 49808574,
          "end": 49808638
        },
        {
          "start": 49808717,
          "end": 49808823
        },
        {
          "start": 49809163,
          "end": 49809258
        },
        {
          "start": 49809378,
          "end": 49809575
        },
        {
          "start": 49811363,
          "end": 49811467
        },
        {
          "start": 49811631,
          "end": 49811699
        },
        {
          "start": 49812251,
          "end": 49812335
        },
        {
          "start": 49812615,
          "end": 49812736
        },
        {
          "start": 49812996,
          "end": 49813292
        }
      ],
      "cds": {
        "start": 49807151,
        "end": 49813106
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "19",
      "start": 50310126,
      "end": 50320633,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 49310079,
      "end": 50310078,
      "genes": [
        {
          "symbol": "SLC6A16",
          "ensemblId": "ENSG00000063127",
          "biotype": "protein_coding",
          "start": 49289638,
          "end": 49325215,
          "strand": "-",
          "slug": "slc6a16"
        },
        {
          "symbol": "CD37",
          "ensemblId": "ENSG00000104894",
          "biotype": "protein_coding",
          "start": 49335171,
          "end": 49343335,
          "strand": "+",
          "slug": "cd37"
        },
        {
          "symbol": "TEAD2",
          "ensemblId": "ENSG00000074219",
          "biotype": "protein_coding",
          "start": 49340389,
          "end": 49362729,
          "strand": "-",
          "slug": "tead2"
        },
        {
          "symbol": "DKKL1",
          "ensemblId": "ENSG00000104901",
          "biotype": "protein_coding",
          "start": 49361783,
          "end": 49375120,
          "strand": "+",
          "slug": "dkkl1"
        },
        {
          "symbol": "KASH5",
          "ensemblId": "ENSG00000161609",
          "biotype": "protein_coding",
          "start": 49388219,
          "end": 49417990,
          "strand": "+",
          "slug": "kash5"
        },
        {
          "symbol": "PTH2",
          "ensemblId": "ENSG00000142538",
          "biotype": "protein_coding",
          "start": 49422419,
          "end": 49423660,
          "strand": "-",
          "slug": "pth2"
        },
        {
          "symbol": "GFY",
          "ensemblId": "ENSG00000261949",
          "biotype": "protein_coding",
          "start": 49423749,
          "end": 49428987,
          "strand": "+",
          "slug": "gfy"
        },
        {
          "symbol": "SLC17A7",
          "ensemblId": "ENSG00000104888",
          "biotype": "protein_coding",
          "start": 49429399,
          "end": 49443197,
          "strand": "-",
          "slug": "slc17a7"
        },
        {
          "symbol": "PIH1D1",
          "ensemblId": "ENSG00000104872",
          "biotype": "protein_coding",
          "start": 49446291,
          "end": 49453537,
          "strand": "-",
          "slug": "pih1d1"
        },
        {
          "symbol": "ALDH16A1",
          "ensemblId": "ENSG00000161618",
          "biotype": "protein_coding",
          "start": 49453146,
          "end": 49471052,
          "strand": "+",
          "slug": "aldh16a1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000269469",
          "biotype": "protein_coding",
          "start": 49462752,
          "end": 49486231,
          "strand": "+"
        },
        {
          "symbol": "FLT3LG",
          "ensemblId": "ENSG00000090554",
          "biotype": "protein_coding",
          "start": 49474150,
          "end": 49486233,
          "strand": "+",
          "slug": "flt3lg"
        },
        {
          "symbol": "RPL13A",
          "ensemblId": "ENSG00000142541",
          "biotype": "protein_coding",
          "start": 49487510,
          "end": 49493057,
          "strand": "+",
          "slug": "rpl13a"
        },
        {
          "symbol": "RPS11",
          "ensemblId": "ENSG00000142534",
          "biotype": "protein_coding",
          "start": 49496233,
          "end": 49499903,
          "strand": "+",
          "slug": "rps11"
        },
        {
          "symbol": "FCGRT",
          "ensemblId": "ENSG00000104870",
          "biotype": "protein_coding",
          "start": 49506806,
          "end": 49526917,
          "strand": "+",
          "slug": "fcgrt"
        },
        {
          "symbol": "RCN3",
          "ensemblId": "ENSG00000142552",
          "biotype": "protein_coding",
          "start": 49526534,
          "end": 49579703,
          "strand": "+",
          "slug": "rcn3"
        },
        {
          "symbol": "NOSIP",
          "ensemblId": "ENSG00000142546",
          "biotype": "protein_coding",
          "start": 49555207,
          "end": 49592927,
          "strand": "-",
          "slug": "nosip"
        },
        {
          "symbol": "PRRG2",
          "ensemblId": "ENSG00000126460",
          "biotype": "protein_coding",
          "start": 49580646,
          "end": 49591004,
          "strand": "+",
          "slug": "prrg2"
        },
        {
          "symbol": "PRR12",
          "ensemblId": "ENSG00000126464",
          "biotype": "protein_coding",
          "start": 49591108,
          "end": 49626439,
          "strand": "+",
          "slug": "prr12"
        },
        {
          "symbol": "RRAS",
          "ensemblId": "ENSG00000126458",
          "biotype": "protein_coding",
          "start": 49634555,
          "end": 49640211,
          "strand": "-",
          "slug": "rras"
        },
        {
          "symbol": "SCAF1",
          "ensemblId": "ENSG00000126461",
          "biotype": "protein_coding",
          "start": 49640488,
          "end": 49658649,
          "strand": "+",
          "slug": "scaf1"
        },
        {
          "symbol": "IRF3",
          "ensemblId": "ENSG00000126456",
          "biotype": "protein_coding",
          "start": 49659569,
          "end": 49665864,
          "strand": "-",
          "slug": "irf3"
        },
        {
          "symbol": "BCL2L12",
          "ensemblId": "ENSG00000126453",
          "biotype": "protein_coding",
          "start": 49664622,
          "end": 49673917,
          "strand": "+",
          "slug": "bcl2l12"
        },
        {
          "symbol": "PRMT1",
          "ensemblId": "ENSG00000126457",
          "biotype": "protein_coding",
          "start": 49675786,
          "end": 49689029,
          "strand": "+",
          "slug": "prmt1"
        },
        {
          "symbol": "ADM5",
          "ensemblId": "ENSG00000224420",
          "biotype": "protein_coding",
          "start": 49688953,
          "end": 49690575,
          "strand": "+",
          "slug": "adm5"
        },
        {
          "symbol": "CPT1C",
          "ensemblId": "ENSG00000169169",
          "biotype": "protein_coding",
          "start": 49690898,
          "end": 49713733,
          "strand": "+",
          "slug": "cpt1c"
        },
        {
          "symbol": "TSKS",
          "ensemblId": "ENSG00000126467",
          "biotype": "protein_coding",
          "start": 49739753,
          "end": 49763329,
          "strand": "-",
          "slug": "tsks"
        },
        {
          "symbol": "AP2A1",
          "ensemblId": "ENSG00000196961",
          "biotype": "protein_coding",
          "start": 49766912,
          "end": 49807114,
          "strand": "+",
          "slug": "ap2a1"
        },
        {
          "symbol": "MED25",
          "ensemblId": "ENSG00000104973",
          "biotype": "protein_coding",
          "start": 49818269,
          "end": 49840384,
          "strand": "+",
          "slug": "med25"
        },
        {
          "symbol": "PTOV1",
          "ensemblId": "ENSG00000104960",
          "biotype": "protein_coding",
          "start": 49850735,
          "end": 49860744,
          "strand": "+",
          "slug": "ptov1"
        },
        {
          "symbol": "PNKP",
          "ensemblId": "ENSG00000039650",
          "biotype": "protein_coding",
          "start": 49859882,
          "end": 49878351,
          "strand": "-",
          "slug": "pnkp"
        },
        {
          "symbol": "AKT1S1",
          "ensemblId": "ENSG00000204673",
          "biotype": "protein_coding",
          "start": 49869023,
          "end": 49879470,
          "strand": "-",
          "slug": "akt1s1"
        },
        {
          "symbol": "TBC1D17",
          "ensemblId": "ENSG00000104946",
          "biotype": "protein_coding",
          "start": 49877501,
          "end": 49888751,
          "strand": "+",
          "slug": "tbc1d17"
        },
        {
          "symbol": "IL4I1",
          "ensemblId": "ENSG00000104951",
          "biotype": "protein_coding",
          "start": 49889654,
          "end": 49929926,
          "strand": "-",
          "slug": "il4i1"
        },
        {
          "symbol": "NUP62",
          "ensemblId": "ENSG00000213024",
          "biotype": "protein_coding",
          "start": 49906825,
          "end": 49929926,
          "strand": "-",
          "slug": "nup62"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000269179",
          "biotype": "protein_coding",
          "start": 49909501,
          "end": 49958391,
          "strand": "-"
        },
        {
          "symbol": "ATF5",
          "ensemblId": "ENSG00000169136",
          "biotype": "protein_coding",
          "start": 49923910,
          "end": 49933935,
          "strand": "+",
          "slug": "atf5"
        },
        {
          "symbol": "SIGLEC11",
          "ensemblId": "ENSG00000161640",
          "biotype": "protein_coding",
          "start": 49948910,
          "end": 49961172,
          "strand": "-",
          "slug": "siglec11"
        },
        {
          "symbol": "SIGLEC16",
          "ensemblId": "ENSG00000161643",
          "biotype": "protein_coding",
          "start": 49969600,
          "end": 49975819,
          "strand": "+",
          "slug": "siglec16"
        },
        {
          "symbol": "VRK3",
          "ensemblId": "ENSG00000105053",
          "biotype": "protein_coding",
          "start": 49974537,
          "end": 50025946,
          "strand": "-",
          "slug": "vrk3"
        },
        {
          "symbol": "ZNF473",
          "ensemblId": "ENSG00000142528",
          "biotype": "protein_coding",
          "start": 50025714,
          "end": 50053414,
          "strand": "+",
          "slug": "znf473"
        },
        {
          "symbol": "IZUMO2",
          "ensemblId": "ENSG00000161652",
          "biotype": "protein_coding",
          "start": 50152537,
          "end": 50163281,
          "strand": "-",
          "slug": "izumo2"
        },
        {
          "symbol": "MYH14",
          "ensemblId": "ENSG00000105357",
          "biotype": "protein_coding",
          "start": 50188181,
          "end": 50310545,
          "strand": "+",
          "slug": "myh14"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-cardiovascular-system-morphology",
        "name": "Abnormal cardiovascular system morphology",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-cardiovascular-system-morphology"
      },
      {
        "slug": "abnormal-iliac-wing-morphology",
        "name": "Abnormal iliac wing morphology",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-iliac-wing-morphology"
      },
      {
        "slug": "ectopic-kidney",
        "name": "Abnormal kidney location",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ectopic-kidney"
      },
      {
        "slug": "abnormal-pelvic-girdle-bone-morphology",
        "name": "Abnormal shape of pelvic girdle bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-pelvic-girdle-bone-morphology"
      },
      {
        "slug": "abnormal-vertebral-segmentation-and-fusion",
        "name": "Abnormal vertebral segmentation and fusion",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-vertebral-segmentation-and-fusion"
      },
      {
        "slug": "abnormality-of-the-ureter",
        "name": "Abnormality of the ureter",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ureter"
      },
      {
        "slug": "absence-of-the-sacrum",
        "name": "Absence of the sacrum",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/absence-of-the-sacrum"
      },
      {
        "slug": "anal-atresia",
        "name": "Absent anus",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anal-atresia"
      },
      {
        "slug": "renal-agenesis",
        "name": "Absent kidney",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/renal-agenesis"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-sacrum",
        "name": "Absent/small sacrum",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-sacrum"
      },
      {
        "slug": "ambiguous-genitalia",
        "name": "Ambiguous external genitalia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ambiguous-genitalia"
      },
      {
        "slug": "anencephaly",
        "name": "Anencephaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/anencephaly"
      },
      {
        "slug": "arrhinencephaly",
        "name": "Arrhinencephaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arrhinencephaly"
      },
      {
        "slug": "asymmetry-of-spinal-facet-joints",
        "name": "Asymmetry of spinal facet joints",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/asymmetry-of-spinal-facet-joints"
      },
      {
        "slug": "chiari-malformation",
        "name": "Chiari malformation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/chiari-malformation"
      },
      {
        "slug": "orofacial-cleft",
        "name": "Cleft of the mouth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/orofacial-cleft"
      },
      {
        "slug": "talipes-equinovarus",
        "name": "Club feet",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/talipes-equinovarus"
      },
      {
        "slug": "decreased-muscle-mass",
        "name": "Decreased muscle mass",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-muscle-mass"
      },
      {
        "slug": "diminished-deep-tendon-reflex",
        "name": "Diminished deep tendon reflex",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/diminished-deep-tendon-reflex"
      },
      {
        "slug": "ureteral-duplication",
        "name": "Double ureter",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ureteral-duplication"
      },
      {
        "slug": "lipoma",
        "name": "Fatty lump",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/lipoma"
      },
      {
        "slug": "hypertension",
        "name": "High blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypertension"
      },
      {
        "slug": "impulsivity",
        "name": "Impulsivity",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/impulsivity"
      },
      {
        "slug": "joint-stiffness",
        "name": "Joint stiffness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/joint-stiffness"
      },
      {
        "slug": "urinary-incontinence",
        "name": "Loss of bladder control",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "constitutional-symptom"
        ],
        "url": "https://dantelabs.com/traits/urinary-incontinence"
      },
      {
        "slug": "bowel-incontinence",
        "name": "Loss of bowel control",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/bowel-incontinence"
      },
      {
        "slug": "missing-ribs",
        "name": "Missing ribs",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/missing-ribs"
      },
      {
        "slug": "multiple-lipomas",
        "name": "Multiple fatty lumps",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/multiple-lipomas"
      },
      {
        "slug": "myelomeningocele",
        "name": "Myelomeningocele",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/myelomeningocele"
      },
      {
        "slug": "pulmonary-hypoplasia",
        "name": "Poorly developed lungs",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pulmonary-hypoplasia"
      },
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "spina-bifida-occulta",
        "name": "Spina bifida occulta",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/spina-bifida-occulta"
      },
      {
        "slug": "sacral-dimple",
        "name": "Spinal dimple",
        "systems": [
          "abnormality-of-the-integument",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/sacral-dimple"
      },
      {
        "slug": "hydrocephalus",
        "name": "Too much cerebrospinal fluid in the brain",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/hydrocephalus"
      },
      {
        "slug": "hypoplastic-vertebral-bodies",
        "name": "Underdeveloped back bones",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypoplastic-vertebral-bodies"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "vesicoureteral-reflux",
        "name": "Vesicoureteral reflux",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vesicoureteral-reflux"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}