{
  "url": "https://dantelabs.com/sv/genes/ankrd26",
  "gene": {
    "slug": "ankrd26",
    "symbol": "ANKRD26",
    "name": "ankyrin repeat domain 26",
    "hgnc": "HGNC:29186",
    "summary": null,
    "location": "10p12.1",
    "locusType": "gene with protein product",
    "aliases": [
      "KIAA1074"
    ],
    "previousSymbols": [
      "THC2"
    ],
    "ensemblId": "ENSG00000107890",
    "entrezId": 22852,
    "omim": [
      "610855"
    ],
    "uniprot": [
      "Q9UPS8"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "10",
      "start": 27004116,
      "end": 27100494,
      "strand": "-",
      "ensemblTranscript": "ENST00000376087.5",
      "refseqTranscript": "NM_014915.3",
      "ensemblProtein": "ENSP00000365255.4",
      "refseqProtein": "NP_055730.2",
      "exons": [
        {
          "start": 27004116,
          "end": 27005723
        },
        {
          "start": 27006917,
          "end": 27006962
        },
        {
          "start": 27012882,
          "end": 27013110
        },
        {
          "start": 27014494,
          "end": 27014711
        },
        {
          "start": 27017502,
          "end": 27017792
        },
        {
          "start": 27022558,
          "end": 27022687
        },
        {
          "start": 27024447,
          "end": 27024559
        },
        {
          "start": 27028852,
          "end": 27028945
        },
        {
          "start": 27029286,
          "end": 27029356
        },
        {
          "start": 27033225,
          "end": 27033377
        },
        {
          "start": 27034796,
          "end": 27035752
        },
        {
          "start": 27037186,
          "end": 27037323
        },
        {
          "start": 27037871,
          "end": 27038054
        },
        {
          "start": 27039965,
          "end": 27040178
        },
        {
          "start": 27043426,
          "end": 27043567
        },
        {
          "start": 27044157,
          "end": 27044190
        },
        {
          "start": 27046353,
          "end": 27046523
        },
        {
          "start": 27048801,
          "end": 27048979
        },
        {
          "start": 27053320,
          "end": 27053390
        },
        {
          "start": 27060345,
          "end": 27060417
        },
        {
          "start": 27060512,
          "end": 27060540
        },
        {
          "start": 27061144,
          "end": 27061242
        },
        {
          "start": 27063988,
          "end": 27064081
        },
        {
          "start": 27066487,
          "end": 27066548
        },
        {
          "start": 27067157,
          "end": 27067286
        },
        {
          "start": 27077338,
          "end": 27077540
        },
        {
          "start": 27077633,
          "end": 27077693
        },
        {
          "start": 27079089,
          "end": 27079161
        },
        {
          "start": 27082803,
          "end": 27082833
        },
        {
          "start": 27086539,
          "end": 27086609
        },
        {
          "start": 27092406,
          "end": 27092512
        },
        {
          "start": 27093349,
          "end": 27093522
        },
        {
          "start": 27093685,
          "end": 27093799
        },
        {
          "start": 27100085,
          "end": 27100494
        }
      ],
      "cds": {
        "start": 27005590,
        "end": 27100326
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "10",
      "start": 27280843,
      "end": 27389421,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 26552305,
      "end": 27552304,
      "genes": [
        {
          "symbol": "APBB1IP",
          "ensemblId": "ENSG00000077420",
          "biotype": "protein_coding",
          "start": 26438160,
          "end": 26568449,
          "strand": "+",
          "slug": "apbb1ip"
        },
        {
          "symbol": "PDSS1",
          "ensemblId": "ENSG00000148459",
          "biotype": "protein_coding",
          "start": 26697441,
          "end": 26746798,
          "strand": "+",
          "slug": "pdss1"
        },
        {
          "symbol": "ABI1",
          "ensemblId": "ENSG00000136754",
          "biotype": "protein_coding",
          "start": 26745266,
          "end": 26861094,
          "strand": "-",
          "slug": "abi1"
        },
        {
          "symbol": "YME1L1",
          "ensemblId": "ENSG00000136758",
          "biotype": "protein_coding",
          "start": 27107777,
          "end": 27155266,
          "strand": "-",
          "slug": "yme1l1"
        },
        {
          "symbol": "MASTL",
          "ensemblId": "ENSG00000120539",
          "biotype": "protein_coding",
          "start": 27154425,
          "end": 27187953,
          "strand": "+",
          "slug": "mastl"
        },
        {
          "symbol": "ACBD5",
          "ensemblId": "ENSG00000107897",
          "biotype": "protein_coding",
          "start": 27168135,
          "end": 27243046,
          "strand": "-",
          "slug": "acbd5"
        },
        {
          "symbol": "PTCHD3",
          "ensemblId": "ENSG00000182077",
          "biotype": "protein_coding",
          "start": 27397121,
          "end": 27414368,
          "strand": "-",
          "slug": "ptchd3"
        },
        {
          "symbol": "RAB18",
          "ensemblId": "ENSG00000099246",
          "biotype": "protein_coding",
          "start": 27504174,
          "end": 27545117,
          "strand": "+",
          "slug": "rab18"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "inherited-thrombocytopenias",
        "name": "Ärftlig trombocytopeni",
        "diseases": [
          {
            "mondoId": "MONDO:0100241",
            "name": "Ärftlig trombocytopeni",
            "genes": 33,
            "inheritance": null,
            "description": "En grupp tillstånd som orsakar ett livslångt lågt antal trombocyter, kopplade till gener som MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 och MECOM, och som ärvs dominant, recessivt eller X-bundet.",
            "management": "En genetisk diagnos förhindrar att tillståndet felaktigt bedöms som immun trombocytopeni, vilket kan leda till onödig behandling med steroider eller borttagning av mjälten, och vägleder uppföljning av relaterade problem i njurar, hörsel eller blod.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/sv/conditions/inherited-thrombocytopenias"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "increased-megakaryocyte-colony-forming-unit-count",
        "name": "Increased megakaryocyte colony forming unit count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-megakaryocyte-colony-forming-unit-count"
      },
      {
        "slug": "thrombocytopenia",
        "name": "Low platelet count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/thrombocytopenia"
      }
    ],
    "related": [
      {
        "slug": "actb",
        "symbol": "ACTB",
        "name": "actin beta",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/actb"
      },
      {
        "slug": "actn1",
        "symbol": "ACTN1",
        "name": "actinin alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/actn1"
      },
      {
        "slug": "adamts13",
        "symbol": "ADAMTS13",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 13",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/adamts13"
      },
      {
        "slug": "arpc1b",
        "symbol": "ARPC1B",
        "name": "actin related protein 2/3 complex subunit 1B",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/arpc1b"
      },
      {
        "slug": "cdc42",
        "symbol": "CDC42",
        "name": "cell division cycle 42",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/cdc42"
      },
      {
        "slug": "cycs",
        "symbol": "CYCS",
        "name": "cytochrome c, somatic",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/cycs"
      },
      {
        "slug": "diaph1",
        "symbol": "DIAPH1",
        "name": "diaphanous related formin 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/diaph1"
      },
      {
        "slug": "etv6",
        "symbol": "ETV6",
        "name": "ETS variant transcription factor 6",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/etv6"
      },
      {
        "slug": "fli1",
        "symbol": "FLI1",
        "name": "Fli-1 proto-oncogene, ETS transcription factor",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/fli1"
      },
      {
        "slug": "fyb1",
        "symbol": "FYB1",
        "name": "FYN binding protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/fyb1"
      },
      {
        "slug": "gale",
        "symbol": "GALE",
        "name": "UDP-galactose-4-epimerase",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/gale"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "name": "GATA binding protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/sv/genes/gata1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}