{
  "url": "https://dantelabs.com/traits/small-cerebral-cortex",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "small-cerebral-cortex",
    "id": "HP:0002472",
    "name": "Small cerebral cortex",
    "definition": "Reduced size of the cerebral cortex.",
    "synonyms": [
      "Decreased volume of cerebral cortex"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cerebral-cortex-morphology",
        "name": "Abnormal cerebral cortex morphology",
        "url": "https://dantelabs.com/traits/abnormal-cerebral-cortex-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "znf335",
        "symbol": "ZNF335",
        "hgnc": "HGNC:15807",
        "name": "zinc finger protein 335",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf335"
      },
      {
        "slug": "tcf4",
        "symbol": "TCF4",
        "hgnc": "HGNC:11634",
        "name": "transcription factor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf4"
      },
      {
        "slug": "cdk13",
        "symbol": "CDK13",
        "hgnc": "HGNC:1733",
        "name": "cyclin dependent kinase 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk13"
      },
      {
        "slug": "aspm",
        "symbol": "ASPM",
        "hgnc": "HGNC:19048",
        "name": "assembly factor for spindle microtubules",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aspm"
      },
      {
        "slug": "cdk5rap2",
        "symbol": "CDK5RAP2",
        "hgnc": "HGNC:18672",
        "name": "CDK5 regulatory subunit associated protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk5rap2"
      },
      {
        "slug": "cpap",
        "symbol": "CPAP",
        "hgnc": "HGNC:17272",
        "name": "centrosome assembly and centriole elongation protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpap"
      },
      {
        "slug": "kif14",
        "symbol": "KIF14",
        "hgnc": "HGNC:19181",
        "name": "kinesin family member 14",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif14"
      },
      {
        "slug": "mcph1",
        "symbol": "MCPH1",
        "hgnc": "HGNC:6954",
        "name": "microcephalin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcph1"
      }
    ]
  }
}