{
  "url": "https://dantelabs.com/traits/slender-build",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "slender-build",
    "id": "HP:0001533",
    "name": "Slender build",
    "definition": "Asthenic habitus refers to a slender build with long limbs, an angular profile, and prominent muscles or bones.",
    "synonyms": [
      "Thin build",
      "Asthenic habitus",
      "Thin body habitus"
    ],
    "systems": [
      {
        "slug": "growth-abnormality",
        "name": "Growth abnormality",
        "url": "https://dantelabs.com/traits/growth-abnormality"
      }
    ],
    "broader": [
      {
        "slug": "decreased-body-weight",
        "name": "Decreased body weight",
        "url": "https://dantelabs.com/traits/decreased-body-weight"
      },
      {
        "slug": "tall-stature",
        "name": "Tall stature",
        "url": "https://dantelabs.com/traits/tall-stature"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "nono",
        "symbol": "NONO",
        "hgnc": "HGNC:7871",
        "name": "non-POU domain containing octamer binding",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nono"
      },
      {
        "slug": "rnu2-2",
        "symbol": "RNU2-2",
        "hgnc": "HGNC:10152",
        "name": "RNA, U2 small nuclear 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu2-2"
      },
      {
        "slug": "fbn2",
        "symbol": "FBN2",
        "hgnc": "HGNC:3604",
        "name": "fibrillin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn2"
      },
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "polr3a",
        "symbol": "POLR3A",
        "hgnc": "HGNC:30074",
        "name": "RNA polymerase III subunit A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3a"
      },
      {
        "slug": "timm50",
        "symbol": "TIMM50",
        "hgnc": "HGNC:23656",
        "name": "translocase of inner mitochondrial membrane 50",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/timm50"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      },
      {
        "slug": "dna2",
        "symbol": "DNA2",
        "hgnc": "HGNC:2939",
        "name": "DNA replication helicase/nuclease 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dna2"
      },
      {
        "slug": "gria3",
        "symbol": "GRIA3",
        "hgnc": "HGNC:4573",
        "name": "glutamate ionotropic receptor AMPA type subunit 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gria3"
      },
      {
        "slug": "herc1",
        "symbol": "HERC1",
        "hgnc": "HGNC:4867",
        "name": "HECT and RLD domain containing E3 ubiquitin protein ligase family member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/herc1"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "sars1",
        "symbol": "SARS1",
        "hgnc": "HGNC:10537",
        "name": "seryl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sars1"
      },
      {
        "slug": "tnnt1",
        "symbol": "TNNT1",
        "hgnc": "HGNC:11948",
        "name": "troponin T1, slow skeletal type",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnt1"
      },
      {
        "slug": "upf3b",
        "symbol": "UPF3B",
        "hgnc": "HGNC:20439",
        "name": "UPF3B regulator of nonsense mediated mRNA decay",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/upf3b"
      },
      {
        "slug": "acta1",
        "symbol": "ACTA1",
        "hgnc": "HGNC:129",
        "name": "actin alpha 1, skeletal muscle",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/acta1"
      },
      {
        "slug": "cic",
        "symbol": "CIC",
        "hgnc": "HGNC:14214",
        "name": "capicua transcriptional repressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cic"
      },
      {
        "slug": "kbtbd13",
        "symbol": "KBTBD13",
        "hgnc": "HGNC:37227",
        "name": "kelch repeat and BTB domain containing 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kbtbd13"
      },
      {
        "slug": "klhl41",
        "symbol": "KLHL41",
        "hgnc": "HGNC:16905",
        "name": "kelch like family member 41",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl41"
      },
      {
        "slug": "mypn",
        "symbol": "MYPN",
        "hgnc": "HGNC:23246",
        "name": "myopalladin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mypn"
      },
      {
        "slug": "neb",
        "symbol": "NEB",
        "hgnc": "HGNC:7720",
        "name": "nebulin",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/neb"
      },
      {
        "slug": "tgfb1",
        "symbol": "TGFB1",
        "hgnc": "HGNC:11766",
        "name": "transforming growth factor beta 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tgfb1"
      },
      {
        "slug": "tpm2",
        "symbol": "TPM2",
        "hgnc": "HGNC:12011",
        "name": "tropomyosin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpm2"
      },
      {
        "slug": "tpm3",
        "symbol": "TPM3",
        "hgnc": "HGNC:12012",
        "name": "tropomyosin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpm3"
      },
      {
        "slug": "col6a1",
        "symbol": "COL6A1",
        "hgnc": "HGNC:2211",
        "name": "collagen type VI alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col6a1"
      },
      {
        "slug": "farsb",
        "symbol": "FARSB",
        "hgnc": "HGNC:17800",
        "name": "phenylalanyl-tRNA synthetase subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/farsb"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "strada",
        "symbol": "STRADA",
        "hgnc": "HGNC:30172",
        "name": "STE20 related adaptor alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/strada"
      },
      {
        "slug": "tubb4a",
        "symbol": "TUBB4A",
        "hgnc": "HGNC:20774",
        "name": "tubulin beta 4A class IVa",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb4a"
      },
      {
        "slug": "tymp",
        "symbol": "TYMP",
        "hgnc": "HGNC:3148",
        "name": "thymidine phosphorylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tymp"
      }
    ]
  }
}