{
  "url": "https://dantelabs.com/traits/shuffling-gait",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "shuffling-gait",
    "id": "HP:0002362",
    "name": "Shuffled walk",
    "label": "Shuffling gait",
    "definition": "A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "gait-disturbance",
        "name": "Abnormal gait",
        "url": "https://dantelabs.com/traits/gait-disturbance"
      }
    ],
    "narrower": [
      {
        "slug": "short-stepped-shuffling-gait",
        "name": "Short stepped shuffling walk",
        "genes": 17,
        "url": "https://dantelabs.com/traits/short-stepped-shuffling-gait"
      }
    ],
    "genes": [
      {
        "slug": "cst3",
        "symbol": "CST3",
        "hgnc": "HGNC:2475",
        "name": "cystatin C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cst3"
      },
      {
        "slug": "ptrhd1",
        "symbol": "PTRHD1",
        "hgnc": "HGNC:33782",
        "name": "peptidyl-tRNA hydrolase domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptrhd1"
      },
      {
        "slug": "slc18a2",
        "symbol": "SLC18A2",
        "hgnc": "HGNC:10935",
        "name": "solute carrier family 18 member A2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc18a2"
      },
      {
        "slug": "fbxo7",
        "symbol": "FBXO7",
        "hgnc": "HGNC:13586",
        "name": "F-box protein 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo7"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "prkar1b",
        "symbol": "PRKAR1B",
        "hgnc": "HGNC:9390",
        "name": "protein kinase cAMP-dependent type I regulatory subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1b"
      },
      {
        "slug": "prkn",
        "symbol": "PRKN",
        "hgnc": "HGNC:8607",
        "name": "parkin RBR E3 ubiquitin protein ligase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkn"
      },
      {
        "slug": "sgcd",
        "symbol": "SGCD",
        "hgnc": "HGNC:10807",
        "name": "sarcoglycan delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sgcd"
      },
      {
        "slug": "snca",
        "symbol": "SNCA",
        "hgnc": "HGNC:11138",
        "name": "synuclein alpha",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/snca"
      },
      {
        "slug": "taf1",
        "symbol": "TAF1",
        "hgnc": "HGNC:11535",
        "name": "TATA-box binding protein associated factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf1"
      },
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "dnajc13",
        "symbol": "DNAJC13",
        "hgnc": "HGNC:30343",
        "name": "DnaJ heat shock protein family (Hsp40) member C13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc13"
      },
      {
        "slug": "dnajc6",
        "symbol": "DNAJC6",
        "hgnc": "HGNC:15469",
        "name": "DnaJ heat shock protein family (Hsp40) member C6",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dnajc6"
      },
      {
        "slug": "eif4g1",
        "symbol": "EIF4G1",
        "hgnc": "HGNC:3296",
        "name": "eukaryotic translation initiation factor 4 gamma 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif4g1"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "gigyf2",
        "symbol": "GIGYF2",
        "hgnc": "HGNC:11960",
        "name": "GRB10 interacting GYF protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gigyf2"
      },
      {
        "slug": "lrrk2",
        "symbol": "LRRK2",
        "hgnc": "HGNC:18618",
        "name": "leucine rich repeat kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrk2"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "naa10",
        "symbol": "NAA10",
        "hgnc": "HGNC:18704",
        "name": "N-alpha-acetyltransferase 10, NatA catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa10"
      },
      {
        "slug": "podxl",
        "symbol": "PODXL",
        "hgnc": "HGNC:9171",
        "name": "podocalyxin like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/podxl"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "rrm1",
        "symbol": "RRM1",
        "hgnc": "HGNC:10451",
        "name": "ribonucleotide reductase catalytic subunit M1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm1"
      },
      {
        "slug": "synj1",
        "symbol": "SYNJ1",
        "hgnc": "HGNC:11503",
        "name": "synaptojanin 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/synj1"
      },
      {
        "slug": "timm8a",
        "symbol": "TIMM8A",
        "hgnc": "HGNC:11817",
        "name": "translocase of inner mitochondrial membrane 8A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/timm8a"
      },
      {
        "slug": "tk2",
        "symbol": "TK2",
        "hgnc": "HGNC:11831",
        "name": "thymidine kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tk2"
      },
      {
        "slug": "tmem106b",
        "symbol": "TMEM106B",
        "hgnc": "HGNC:22407",
        "name": "transmembrane protein 106B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem106b"
      },
      {
        "slug": "top3a",
        "symbol": "TOP3A",
        "hgnc": "HGNC:11992",
        "name": "DNA topoisomerase III alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top3a"
      },
      {
        "slug": "vapb",
        "symbol": "VAPB",
        "hgnc": "HGNC:12649",
        "name": "VAMP associated protein B and C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vapb"
      },
      {
        "slug": "vps35",
        "symbol": "VPS35",
        "hgnc": "HGNC:13487",
        "name": "VPS35 retromer complex component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps35"
      },
      {
        "slug": "csf1r",
        "symbol": "CSF1R",
        "hgnc": "HGNC:2433",
        "name": "colony stimulating factor 1 receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf1r"
      },
      {
        "slug": "kdm5c",
        "symbol": "KDM5C",
        "hgnc": "HGNC:11114",
        "name": "lysine demethylase 5C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm5c"
      },
      {
        "slug": "l1cam",
        "symbol": "L1CAM",
        "hgnc": "HGNC:6470",
        "name": "L1 cell adhesion molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/l1cam"
      },
      {
        "slug": "rab39b",
        "symbol": "RAB39B",
        "hgnc": "HGNC:16499",
        "name": "RAB39B, member RAS oncogene family",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab39b"
      }
    ]
  }
}