{
  "url": "https://dantelabs.com/traits/seborrheic-dermatitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "seborrheic-dermatitis",
    "id": "HP:0001051",
    "name": "Seborrheic dermatitis",
    "definition": "Seborrheic dermatitis is a form of eczema which is closely related to dandruff. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk.",
    "synonyms": [
      "Seborrhea",
      "Seborrheic eczema"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "eczematoid-dermatitis",
        "name": "Eczema",
        "url": "https://dantelabs.com/traits/eczematoid-dermatitis"
      }
    ],
    "narrower": [
      {
        "slug": "generalized-seborrheic-dermatitis",
        "name": "Generalized seborrheic dermatitis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/generalized-seborrheic-dermatitis"
      }
    ],
    "genes": [
      {
        "slug": "slco2a1",
        "symbol": "SLCO2A1",
        "hgnc": "HGNC:10955",
        "name": "solute carrier organic anion transporter family member 2A1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/slco2a1"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "traf3ip2",
        "symbol": "TRAF3IP2",
        "hgnc": "HGNC:1343",
        "name": "TRAF3 interacting protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3ip2"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "cib1",
        "symbol": "CIB1",
        "hgnc": "HGNC:16920",
        "name": "calcium and integrin binding 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cib1"
      },
      {
        "slug": "gpr101",
        "symbol": "GPR101",
        "hgnc": "HGNC:14963",
        "name": "G protein-coupled receptor 101",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr101"
      },
      {
        "slug": "hpgd",
        "symbol": "HPGD",
        "hgnc": "HGNC:5154",
        "name": "15-hydroxyprostaglandin dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hpgd"
      },
      {
        "slug": "il7",
        "symbol": "IL7",
        "hgnc": "HGNC:6023",
        "name": "interleukin 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il7"
      },
      {
        "slug": "tmc6",
        "symbol": "TMC6",
        "hgnc": "HGNC:18021",
        "name": "transmembrane channel like 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmc6"
      },
      {
        "slug": "tmc8",
        "symbol": "TMC8",
        "hgnc": "HGNC:20474",
        "name": "transmembrane channel like 8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmc8"
      },
      {
        "slug": "arvcf",
        "symbol": "ARVCF",
        "hgnc": "HGNC:728",
        "name": "ARVCF delta catenin family member",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arvcf"
      },
      {
        "slug": "comt",
        "symbol": "COMT",
        "hgnc": "HGNC:2228",
        "name": "catechol-O-methyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/comt"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "hira",
        "symbol": "HIRA",
        "hgnc": "HGNC:4916",
        "name": "histone cell cycle regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hira"
      },
      {
        "slug": "jmjd1c",
        "symbol": "JMJD1C",
        "hgnc": "HGNC:12313",
        "name": "jumonji domain containing 1C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jmjd1c"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "rreb1",
        "symbol": "RREB1",
        "hgnc": "HGNC:10449",
        "name": "ras responsive element binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rreb1"
      },
      {
        "slug": "sec24c",
        "symbol": "SEC24C",
        "hgnc": "HGNC:10705",
        "name": "SEC24 homolog C, COPII component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec24c"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "ufd1",
        "symbol": "UFD1",
        "hgnc": "HGNC:12520",
        "name": "ubiquitin recognition factor in ER associated degradation 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ufd1"
      },
      {
        "slug": "carmil2",
        "symbol": "CARMIL2",
        "hgnc": "HGNC:27089",
        "name": "capping protein regulator and myosin 1 linker 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/carmil2"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "slc39a7",
        "symbol": "SLC39A7",
        "hgnc": "HGNC:4927",
        "name": "solute carrier family 39 member 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc39a7"
      },
      {
        "slug": "tkt",
        "symbol": "TKT",
        "hgnc": "HGNC:11834",
        "name": "transketolase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tkt"
      },
      {
        "slug": "btd",
        "symbol": "BTD",
        "hgnc": "HGNC:1122",
        "name": "biotinidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btd"
      },
      {
        "slug": "mccc2",
        "symbol": "MCCC2",
        "hgnc": "HGNC:6937",
        "name": "methylcrotonyl-CoA carboxylase subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mccc2"
      },
      {
        "slug": "rbm8a",
        "symbol": "RBM8A",
        "hgnc": "HGNC:9905",
        "name": "RNA binding motif protein 8A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbm8a"
      },
      {
        "slug": "znf750",
        "symbol": "ZNF750",
        "hgnc": "HGNC:25843",
        "name": "zinc finger protein 750",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf750"
      }
    ]
  }
}