{
  "url": "https://dantelabs.com/traits/reduced-factor-vii-activity",
  "trait": {
    "bundleId": "2026.10.21-311f020e",
    "release": "2026-09-01",
    "slug": "reduced-factor-vii-activity",
    "id": "HP:0008169",
    "name": "Reduced factor VII activity",
    "definition": "Reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-extrinsic-pathway",
        "name": "Abnormality of the extrinsic pathway",
        "url": "https://dantelabs.com/traits/abnormality-of-the-extrinsic-pathway"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "f7",
        "symbol": "F7",
        "hgnc": "HGNC:3544",
        "name": "coagulation factor VII",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f7"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "ahcy",
        "symbol": "AHCY",
        "hgnc": "HGNC:343",
        "name": "adenosylhomocysteinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahcy"
      },
      {
        "slug": "vkorc1",
        "symbol": "VKORC1",
        "hgnc": "HGNC:23663",
        "name": "vitamin K epoxide reductase complex subunit 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vkorc1"
      }
    ]
  }
}