{
  "url": "https://dantelabs.com/traits/open-mouth",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "open-mouth",
    "id": "HP:0000194",
    "name": "Open mouth",
    "definition": "A facial appearance characterized by a permanently or nearly permanently opened mouth.",
    "synonyms": [
      "Gaped jawed appearance",
      "Gaped mouthed appearance",
      "Open mouth appearance",
      "Slack jawed appearance"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-mouth-shape",
        "name": "Abnormality of mouth shape",
        "url": "https://dantelabs.com/traits/abnormality-of-mouth-shape"
      }
    ],
    "narrower": [
      {
        "slug": "triangular-shaped-open-mouth",
        "name": "Triangular-shaped open mouth",
        "genes": 3,
        "url": "https://dantelabs.com/traits/triangular-shaped-open-mouth"
      }
    ],
    "genes": [
      {
        "slug": "adam22",
        "symbol": "ADAM22",
        "hgnc": "HGNC:201",
        "name": "ADAM metallopeptidase domain 22",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adam22"
      },
      {
        "slug": "ash1l",
        "symbol": "ASH1L",
        "hgnc": "HGNC:19088",
        "name": "ASH1 like histone lysine methyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ash1l"
      },
      {
        "slug": "bcas3",
        "symbol": "BCAS3",
        "hgnc": "HGNC:14347",
        "name": "BCAS3 microtubule associated cell migration factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcas3"
      },
      {
        "slug": "ccdc88a",
        "symbol": "CCDC88A",
        "hgnc": "HGNC:25523",
        "name": "coiled-coil and HOOK domain protein 88A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc88a"
      },
      {
        "slug": "chd8",
        "symbol": "CHD8",
        "hgnc": "HGNC:20153",
        "name": "chromodomain helicase DNA binding protein 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd8"
      },
      {
        "slug": "dennd5a",
        "symbol": "DENND5A",
        "hgnc": "HGNC:19344",
        "name": "DENN domain containing 5A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dennd5a"
      },
      {
        "slug": "dst",
        "symbol": "DST",
        "hgnc": "HGNC:1090",
        "name": "dystonin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dst"
      },
      {
        "slug": "gcsh",
        "symbol": "GCSH",
        "hgnc": "HGNC:4208",
        "name": "glycine cleavage system protein H",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcsh"
      },
      {
        "slug": "hoxb1",
        "symbol": "HOXB1",
        "hgnc": "HGNC:5111",
        "name": "homeobox B1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxb1"
      },
      {
        "slug": "inpp4a",
        "symbol": "INPP4A",
        "hgnc": "HGNC:6074",
        "name": "inositol polyphosphate-4-phosphatase type I A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp4a"
      },
      {
        "slug": "mtor",
        "symbol": "MTOR",
        "hgnc": "HGNC:3942",
        "name": "mechanistic target of rapamycin kinase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mtor"
      },
      {
        "slug": "nexmif",
        "symbol": "NEXMIF",
        "hgnc": "HGNC:29433",
        "name": "neurite extension and migration factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nexmif"
      },
      {
        "slug": "nono",
        "symbol": "NONO",
        "hgnc": "HGNC:7871",
        "name": "non-POU domain containing octamer binding",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nono"
      },
      {
        "slug": "rnu2-2",
        "symbol": "RNU2-2",
        "hgnc": "HGNC:10152",
        "name": "RNA, U2 small nuclear 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu2-2"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn4a"
      },
      {
        "slug": "slc35a2",
        "symbol": "SLC35A2",
        "hgnc": "HGNC:11022",
        "name": "solute carrier family 35 member A2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35a2"
      },
      {
        "slug": "ap1s2",
        "symbol": "AP1S2",
        "hgnc": "HGNC:560",
        "name": "adaptor related protein complex 1 subunit sigma 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1s2"
      },
      {
        "slug": "champ1",
        "symbol": "CHAMP1",
        "hgnc": "HGNC:20311",
        "name": "chromosome alignment maintaining phosphoprotein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/champ1"
      },
      {
        "slug": "dis3l2",
        "symbol": "DIS3L2",
        "hgnc": "HGNC:28648",
        "name": "DIS3 like 3'-5' exoribonuclease 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dis3l2"
      },
      {
        "slug": "kcnj6",
        "symbol": "KCNJ6",
        "hgnc": "HGNC:6267",
        "name": "potassium inwardly rectifying channel subfamily J member 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj6"
      },
      {
        "slug": "pak3",
        "symbol": "PAK3",
        "hgnc": "HGNC:8592",
        "name": "p21 (RAC1) activated kinase 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pak3"
      },
      {
        "slug": "pde4d",
        "symbol": "PDE4D",
        "hgnc": "HGNC:8783",
        "name": "phosphodiesterase 4D",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde4d"
      },
      {
        "slug": "plxnd1",
        "symbol": "PLXND1",
        "hgnc": "HGNC:9107",
        "name": "plexin D1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plxnd1"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      },
      {
        "slug": "rev3l",
        "symbol": "REV3L",
        "hgnc": "HGNC:9968",
        "name": "REV3 like, DNA directed polymerase zeta catalytic subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rev3l"
      },
      {
        "slug": "rps6ka3",
        "symbol": "RPS6KA3",
        "hgnc": "HGNC:10432",
        "name": "ribosomal protein S6 kinase A3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rps6ka3"
      },
      {
        "slug": "slc9a6",
        "symbol": "SLC9A6",
        "hgnc": "HGNC:11079",
        "name": "solute carrier family 9 member A6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc9a6"
      },
      {
        "slug": "vps13b",
        "symbol": "VPS13B",
        "hgnc": "HGNC:2183",
        "name": "vacuolar protein sorting 13 homolog B",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vps13b"
      },
      {
        "slug": "znhit3",
        "symbol": "ZNHIT3",
        "hgnc": "HGNC:12309",
        "name": "zinc finger HIT-type containing 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/znhit3"
      },
      {
        "slug": "ago2",
        "symbol": "AGO2",
        "hgnc": "HGNC:3263",
        "name": "argonaute RISC catalytic component 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ago2"
      },
      {
        "slug": "ankle2",
        "symbol": "ANKLE2",
        "hgnc": "HGNC:29101",
        "name": "ankyrin repeat and LEM domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankle2"
      },
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "csnk2b",
        "symbol": "CSNK2B",
        "hgnc": "HGNC:2460",
        "name": "casein kinase 2 beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csnk2b"
      },
      {
        "slug": "ecel1",
        "symbol": "ECEL1",
        "hgnc": "HGNC:3147",
        "name": "endothelin converting enzyme like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ecel1"
      },
      {
        "slug": "eln",
        "symbol": "ELN",
        "hgnc": "HGNC:3327",
        "name": "elastin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eln"
      },
      {
        "slug": "foxp1",
        "symbol": "FOXP1",
        "hgnc": "HGNC:3823",
        "name": "forkhead box P1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/foxp1"
      },
      {
        "slug": "hnrnpk",
        "symbol": "HNRNPK",
        "hgnc": "HGNC:5044",
        "name": "heterogeneous nuclear ribonucleoprotein K",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hnrnpk"
      },
      {
        "slug": "kcnk9",
        "symbol": "KCNK9",
        "hgnc": "HGNC:6283",
        "name": "potassium two pore domain channel subfamily K member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnk9"
      },
      {
        "slug": "mbd5",
        "symbol": "MBD5",
        "hgnc": "HGNC:20444",
        "name": "methyl-CpG binding domain protein 5",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mbd5"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "med13l",
        "symbol": "MED13L",
        "hgnc": "HGNC:22962",
        "name": "mediator complex subunit 13L",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/med13l"
      },
      {
        "slug": "mlxipl",
        "symbol": "MLXIPL",
        "hgnc": "HGNC:12744",
        "name": "MLX interacting protein like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlxipl"
      },
      {
        "slug": "nfix",
        "symbol": "NFIX",
        "hgnc": "HGNC:7788",
        "name": "nuclear factor I X",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfix"
      },
      {
        "slug": "nkap",
        "symbol": "NKAP",
        "hgnc": "HGNC:29873",
        "name": "NFKB activating protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkap"
      },
      {
        "slug": "ogt",
        "symbol": "OGT",
        "hgnc": "HGNC:8127",
        "name": "O-linked N-acetylglucosamine (GlcNAc) transferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ogt"
      },
      {
        "slug": "pdzd8",
        "symbol": "PDZD8",
        "hgnc": "HGNC:26974",
        "name": "PDZ domain containing 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdzd8"
      },
      {
        "slug": "pigf",
        "symbol": "PIGF",
        "hgnc": "HGNC:8962",
        "name": "phosphatidylinositol glycan anchor biosynthesis class F",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigf"
      },
      {
        "slug": "pigl",
        "symbol": "PIGL",
        "hgnc": "HGNC:8966",
        "name": "phosphatidylinositol glycan anchor biosynthesis class L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigl"
      },
      {
        "slug": "pogz",
        "symbol": "POGZ",
        "hgnc": "HGNC:18801",
        "name": "pogo transposable element derived with ZNF domain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pogz"
      },
      {
        "slug": "ppp2r1a",
        "symbol": "PPP2R1A",
        "hgnc": "HGNC:9302",
        "name": "protein phosphatase 2 scaffold subunit Aalpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ppp2r1a"
      },
      {
        "slug": "rai1",
        "symbol": "RAI1",
        "hgnc": "HGNC:9834",
        "name": "retinoic acid induced 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rai1"
      },
      {
        "slug": "rbsn",
        "symbol": "RBSN",
        "hgnc": "HGNC:20759",
        "name": "rabenosyn, RAB effector",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbsn"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      },
      {
        "slug": "rps23",
        "symbol": "RPS23",
        "hgnc": "HGNC:10410",
        "name": "ribosomal protein S23",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps23"
      },
      {
        "slug": "slc6a8",
        "symbol": "SLC6A8",
        "hgnc": "HGNC:11055",
        "name": "solute carrier family 6 member 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a8"
      },
      {
        "slug": "sox11",
        "symbol": "SOX11",
        "hgnc": "HGNC:11191",
        "name": "SRY-box transcription factor 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox11"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbc1d24"
      },
      {
        "slug": "tet3",
        "symbol": "TET3",
        "hgnc": "HGNC:28313",
        "name": "tet methylcytosine dioxygenase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet3"
      },
      {
        "slug": "tfe3",
        "symbol": "TFE3",
        "hgnc": "HGNC:11752",
        "name": "transcription factor binding to IGHM enhancer 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfe3"
      },
      {
        "slug": "tubb4a",
        "symbol": "TUBB4A",
        "hgnc": "HGNC:20774",
        "name": "tubulin beta 4A class IVa",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb4a"
      },
      {
        "slug": "wdr83os",
        "symbol": "WDR83OS",
        "hgnc": "HGNC:30203",
        "name": "WD repeat domain 83 opposite strand",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr83os"
      },
      {
        "slug": "zeb2",
        "symbol": "ZEB2",
        "hgnc": "HGNC:14881",
        "name": "zinc finger E-box binding homeobox 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zeb2"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "asxl3",
        "symbol": "ASXL3",
        "hgnc": "HGNC:29357",
        "name": "ASXL transcriptional regulator 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl3"
      },
      {
        "slug": "cacna1i",
        "symbol": "CACNA1I",
        "hgnc": "HGNC:1396",
        "name": "calcium voltage-gated channel subunit alpha1 I",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1i"
      },
      {
        "slug": "creld1",
        "symbol": "CRELD1",
        "hgnc": "HGNC:14630",
        "name": "CRELD disulfide isomerase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/creld1"
      },
      {
        "slug": "dhx30",
        "symbol": "DHX30",
        "hgnc": "HGNC:16716",
        "name": "DExH-box helicase 30",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhx30"
      },
      {
        "slug": "dlk1",
        "symbol": "DLK1",
        "hgnc": "HGNC:2907",
        "name": "delta like non-canonical Notch ligand 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlk1"
      },
      {
        "slug": "dpyd",
        "symbol": "DPYD",
        "hgnc": "HGNC:3012",
        "name": "dihydropyrimidine dehydrogenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpyd"
      },
      {
        "slug": "extl3",
        "symbol": "EXTL3",
        "hgnc": "HGNC:3518",
        "name": "exostosin like glycosyltransferase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/extl3"
      },
      {
        "slug": "fam149b1",
        "symbol": "FAM149B1",
        "hgnc": "HGNC:29162",
        "name": "family with sequence similarity 149 member B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam149b1"
      },
      {
        "slug": "gfm2",
        "symbol": "GFM2",
        "hgnc": "HGNC:29682",
        "name": "GTP dependent ribosome recycling factor mitochondrial 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfm2"
      },
      {
        "slug": "gria3",
        "symbol": "GRIA3",
        "hgnc": "HGNC:4573",
        "name": "glutamate ionotropic receptor AMPA type subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gria3"
      },
      {
        "slug": "h3-3a",
        "symbol": "H3-3A",
        "hgnc": "HGNC:4764",
        "name": "H3.3 histone A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h3-3a"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "kcnh1",
        "symbol": "KCNH1",
        "hgnc": "HGNC:6250",
        "name": "potassium voltage-gated channel subfamily H member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnh1"
      },
      {
        "slug": "kdm2b",
        "symbol": "KDM2B",
        "hgnc": "HGNC:13610",
        "name": "lysine demethylase 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm2b"
      },
      {
        "slug": "kif7",
        "symbol": "KIF7",
        "hgnc": "HGNC:30497",
        "name": "kinesin family member 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif7"
      },
      {
        "slug": "lama2",
        "symbol": "LAMA2",
        "hgnc": "HGNC:6482",
        "name": "laminin subunit alpha 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama2"
      },
      {
        "slug": "med12l",
        "symbol": "MED12L",
        "hgnc": "HGNC:16050",
        "name": "mediator complex subunit 12L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12l"
      },
      {
        "slug": "mef2c",
        "symbol": "MEF2C",
        "hgnc": "HGNC:6996",
        "name": "myocyte enhancer factor 2C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mef2c"
      },
      {
        "slug": "meg3",
        "symbol": "MEG3",
        "hgnc": "HGNC:14575",
        "name": "maternally expressed 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/meg3"
      },
      {
        "slug": "mgat2",
        "symbol": "MGAT2",
        "hgnc": "HGNC:7045",
        "name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mgat2"
      },
      {
        "slug": "ngly1",
        "symbol": "NGLY1",
        "hgnc": "HGNC:17646",
        "name": "N-glycanase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngly1"
      },
      {
        "slug": "ocrl",
        "symbol": "OCRL",
        "hgnc": "HGNC:8108",
        "name": "OCRL inositol polyphosphate-5-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ocrl"
      },
      {
        "slug": "polrmt",
        "symbol": "POLRMT",
        "hgnc": "HGNC:9200",
        "name": "RNA polymerase mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polrmt"
      },
      {
        "slug": "rac1",
        "symbol": "RAC1",
        "hgnc": "HGNC:9801",
        "name": "Rac family small GTPase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rac1"
      },
      {
        "slug": "rap1b",
        "symbol": "RAP1B",
        "hgnc": "HGNC:9857",
        "name": "RAP1B, member of RAS oncogene family",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rap1b"
      },
      {
        "slug": "rtl1",
        "symbol": "RTL1",
        "hgnc": "HGNC:14665",
        "name": "retrotransposon Gag like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtl1"
      },
      {
        "slug": "setbp1",
        "symbol": "SETBP1",
        "hgnc": "HGNC:15573",
        "name": "SET binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setbp1"
      },
      {
        "slug": "strada",
        "symbol": "STRADA",
        "hgnc": "HGNC:30172",
        "name": "STE20 related adaptor alpha",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/strada"
      },
      {
        "slug": "tbck",
        "symbol": "TBCK",
        "hgnc": "HGNC:28261",
        "name": "TBC1 domain containing kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbck"
      },
      {
        "slug": "ctcf",
        "symbol": "CTCF",
        "hgnc": "HGNC:13723",
        "name": "CCCTC-binding factor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctcf"
      },
      {
        "slug": "ahi1",
        "symbol": "AHI1",
        "hgnc": "HGNC:21575",
        "name": "Abelson helper integration site 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahi1"
      },
      {
        "slug": "atn1",
        "symbol": "ATN1",
        "hgnc": "HGNC:3033",
        "name": "atrophin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atn1"
      },
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "braf",
        "symbol": "BRAF",
        "hgnc": "HGNC:1097",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/braf"
      },
      {
        "slug": "ccdc174",
        "symbol": "CCDC174",
        "hgnc": "HGNC:28033",
        "name": "coiled-coil domain containing 174",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc174"
      },
      {
        "slug": "cltc",
        "symbol": "CLTC",
        "hgnc": "HGNC:2092",
        "name": "clathrin heavy chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cltc"
      },
      {
        "slug": "dgcr2",
        "symbol": "DGCR2",
        "hgnc": "HGNC:2845",
        "name": "DiGeorge syndrome critical region gene 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgcr2"
      },
      {
        "slug": "dgcr6",
        "symbol": "DGCR6",
        "hgnc": "HGNC:2846",
        "name": "DiGeorge syndrome critical region gene 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgcr6"
      },
      {
        "slug": "dgcr8",
        "symbol": "DGCR8",
        "hgnc": "HGNC:2847",
        "name": "DGCR8 microprocessor complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgcr8"
      },
      {
        "slug": "eif2s3",
        "symbol": "EIF2S3",
        "hgnc": "HGNC:3267",
        "name": "eukaryotic translation initiation factor 2 subunit gamma",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2s3"
      },
      {
        "slug": "ess2",
        "symbol": "ESS2",
        "hgnc": "HGNC:16817",
        "name": "ess-2 spliceosome associated protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ess2"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "hras",
        "symbol": "HRAS",
        "hgnc": "HGNC:5173",
        "name": "HRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hras"
      },
      {
        "slug": "il1rapl1",
        "symbol": "IL1RAPL1",
        "hgnc": "HGNC:5996",
        "name": "interleukin 1 receptor accessory protein like 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il1rapl1"
      },
      {
        "slug": "kansl1",
        "symbol": "KANSL1",
        "hgnc": "HGNC:24565",
        "name": "KAT8 regulatory NSL complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kansl1"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "magel2",
        "symbol": "MAGEL2",
        "hgnc": "HGNC:6814",
        "name": "MAGE family member L2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/magel2"
      },
      {
        "slug": "map2k1",
        "symbol": "MAP2K1",
        "hgnc": "HGNC:6840",
        "name": "mitogen-activated protein kinase kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k1"
      },
      {
        "slug": "map2k2",
        "symbol": "MAP2K2",
        "hgnc": "HGNC:6842",
        "name": "mitogen-activated protein kinase kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k2"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      },
      {
        "slug": "pars2",
        "symbol": "PARS2",
        "hgnc": "HGNC:30563",
        "name": "prolyl-tRNA synthetase 2, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pars2"
      },
      {
        "slug": "pign",
        "symbol": "PIGN",
        "hgnc": "HGNC:8967",
        "name": "phosphatidylinositol glycan anchor biosynthesis class N",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pign"
      },
      {
        "slug": "pigt",
        "symbol": "PIGT",
        "hgnc": "HGNC:14938",
        "name": "phosphatidylinositol glycan anchor biosynthesis class T",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigt"
      },
      {
        "slug": "pomt2",
        "symbol": "POMT2",
        "hgnc": "HGNC:19743",
        "name": "protein O-mannosyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomt2"
      },
      {
        "slug": "ppp2r5d",
        "symbol": "PPP2R5D",
        "hgnc": "HGNC:9312",
        "name": "protein phosphatase 2 regulatory subunit B'delta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r5d"
      },
      {
        "slug": "pura",
        "symbol": "PURA",
        "hgnc": "HGNC:9701",
        "name": "purine rich element binding protein A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pura"
      },
      {
        "slug": "pus7",
        "symbol": "PUS7",
        "hgnc": "HGNC:26033",
        "name": "pseudouridine synthase 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pus7"
      },
      {
        "slug": "sin3a",
        "symbol": "SIN3A",
        "hgnc": "HGNC:19353",
        "name": "SIN3 transcription regulator family member A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sin3a"
      },
      {
        "slug": "sox5",
        "symbol": "SOX5",
        "hgnc": "HGNC:11201",
        "name": "SRY-box transcription factor 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox5"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "tcf20",
        "symbol": "TCF20",
        "hgnc": "HGNC:11631",
        "name": "transcription factor 20",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf20"
      },
      {
        "slug": "tcf4",
        "symbol": "TCF4",
        "hgnc": "HGNC:11634",
        "name": "transcription factor 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf4"
      },
      {
        "slug": "tmem237",
        "symbol": "TMEM237",
        "hgnc": "HGNC:14432",
        "name": "transmembrane protein 237",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem237"
      },
      {
        "slug": "unc80",
        "symbol": "UNC80",
        "hgnc": "HGNC:26582",
        "name": "unc-80 subunit of NALCN channel complex",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc80"
      },
      {
        "slug": "zswim6",
        "symbol": "ZSWIM6",
        "hgnc": "HGNC:29316",
        "name": "zinc finger SWIM-type containing 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zswim6"
      }
    ]
  }
}