{
  "url": "https://dantelabs.com/traits/negativism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "negativism",
    "id": "HP:0410291",
    "name": "Negativism",
    "definition": "Opposing or not responding to instructions or external stimuli.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-diminished-volition",
        "name": "Diminished motivation",
        "url": "https://dantelabs.com/traits/abnormal-diminished-volition"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "apol2",
        "symbol": "APOL2",
        "hgnc": "HGNC:619",
        "name": "apolipoprotein L2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apol2"
      },
      {
        "slug": "chi3l1",
        "symbol": "CHI3L1",
        "hgnc": "HGNC:1932",
        "name": "chitinase 3 like 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chi3l1"
      },
      {
        "slug": "daoa",
        "symbol": "DAOA",
        "hgnc": "HGNC:21191",
        "name": "D-amino acid oxidase activator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daoa"
      },
      {
        "slug": "disc2",
        "symbol": "DISC2",
        "hgnc": "HGNC:2889",
        "name": "disrupted in schizophrenia 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/disc2"
      },
      {
        "slug": "drd3",
        "symbol": "DRD3",
        "hgnc": "HGNC:3024",
        "name": "dopamine receptor D3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drd3"
      },
      {
        "slug": "htr2a",
        "symbol": "HTR2A",
        "hgnc": "HGNC:5293",
        "name": "5-hydroxytryptamine receptor 2A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htr2a"
      },
      {
        "slug": "mthfr",
        "symbol": "MTHFR",
        "hgnc": "HGNC:7436",
        "name": "methylenetetrahydrofolate reductase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfr"
      },
      {
        "slug": "rtn4r",
        "symbol": "RTN4R",
        "hgnc": "HGNC:18601",
        "name": "reticulon 4 receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtn4r"
      },
      {
        "slug": "syn2",
        "symbol": "SYN2",
        "hgnc": "HGNC:11495",
        "name": "synapsin II",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syn2"
      }
    ]
  }
}