{
  "url": "https://dantelabs.com/traits/motor-deterioration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "motor-deterioration",
    "id": "HP:0002333",
    "name": "Progressive degeneration of movement",
    "label": "Motor deterioration",
    "definition": "Loss of previously present motor (i.e., movement) abilities.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "mental-deterioration",
        "name": "Mental deterioration",
        "url": "https://dantelabs.com/traits/mental-deterioration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gprc5b",
        "symbol": "GPRC5B",
        "hgnc": "HGNC:13308",
        "name": "G protein-coupled receptor class C group 5 member B",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gprc5b"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "pdha1",
        "symbol": "PDHA1",
        "hgnc": "HGNC:8806",
        "name": "pyruvate dehydrogenase E1 subunit alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdha1"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "rbm28",
        "symbol": "RBM28",
        "hgnc": "HGNC:21863",
        "name": "RNA binding motif protein 28",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rbm28"
      },
      {
        "slug": "prkar1b",
        "symbol": "PRKAR1B",
        "hgnc": "HGNC:9390",
        "name": "protein kinase cAMP-dependent type I regulatory subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1b"
      },
      {
        "slug": "aqp4",
        "symbol": "AQP4",
        "hgnc": "HGNC:637",
        "name": "aquaporin 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aqp4"
      },
      {
        "slug": "cln8",
        "symbol": "CLN8",
        "hgnc": "HGNC:2079",
        "name": "CLN8 transmembrane ER and ERGIC protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cln8"
      },
      {
        "slug": "hepacam",
        "symbol": "HEPACAM",
        "hgnc": "HGNC:26361",
        "name": "hepatic and glial cell adhesion molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hepacam"
      },
      {
        "slug": "hgsnat",
        "symbol": "HGSNAT",
        "hgnc": "HGNC:26527",
        "name": "heparan-alpha-glucosaminide N-acetyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hgsnat"
      },
      {
        "slug": "mlc1",
        "symbol": "MLC1",
        "hgnc": "HGNC:17082",
        "name": "modulator of VRAC current 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlc1"
      },
      {
        "slug": "plekhg4",
        "symbol": "PLEKHG4",
        "hgnc": "HGNC:24501",
        "name": "pleckstrin homology and RhoGEF domain containing G4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plekhg4"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sdhaf1",
        "symbol": "SDHAF1",
        "hgnc": "HGNC:33867",
        "name": "succinate dehydrogenase complex assembly factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhaf1"
      },
      {
        "slug": "sdhb",
        "symbol": "SDHB",
        "hgnc": "HGNC:10681",
        "name": "succinate dehydrogenase complex iron sulfur subunit B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhb"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "grin2a",
        "symbol": "GRIN2A",
        "hgnc": "HGNC:4585",
        "name": "glutamate ionotropic receptor NMDA type subunit 2A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grin2a"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "cln5",
        "symbol": "CLN5",
        "hgnc": "HGNC:2076",
        "name": "CLN5 lysosomal BMP synthase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cln5"
      },
      {
        "slug": "cln6",
        "symbol": "CLN6",
        "hgnc": "HGNC:2077",
        "name": "CLN6 transmembrane ER protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cln6"
      },
      {
        "slug": "galc",
        "symbol": "GALC",
        "hgnc": "HGNC:4115",
        "name": "galactosylceramidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galc"
      }
    ]
  }
}