{
  "url": "https://dantelabs.com/traits/left-isomerism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "left-isomerism",
    "id": "HP:0031854",
    "name": "Left Isomerism",
    "definition": "A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal left-sided structures.",
    "synonyms": [
      "Left-sided isomerism"
    ],
    "systems": [
      {
        "slug": "growth-abnormality",
        "name": "Growth abnormality",
        "url": "https://dantelabs.com/traits/growth-abnormality"
      }
    ],
    "broader": [
      {
        "slug": "isomerism",
        "name": "Isomerism",
        "url": "https://dantelabs.com/traits/isomerism"
      }
    ],
    "narrower": [
      {
        "slug": "left-atrial-isomerism",
        "name": "Left atrial isomerism",
        "genes": 2,
        "url": "https://dantelabs.com/traits/left-atrial-isomerism"
      }
    ],
    "genes": [
      {
        "slug": "ciroz",
        "symbol": "CIROZ",
        "hgnc": "HGNC:26730",
        "name": "ciliated left-right organizer protein containing ZP-N domains",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciroz"
      },
      {
        "slug": "dnah9",
        "symbol": "DNAH9",
        "hgnc": "HGNC:2953",
        "name": "dynein axonemal heavy chain 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah9"
      },
      {
        "slug": "sox17",
        "symbol": "SOX17",
        "hgnc": "HGNC:18122",
        "name": "SRY-box transcription factor 17",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox17"
      },
      {
        "slug": "cirop",
        "symbol": "CIROP",
        "hgnc": "HGNC:53647",
        "name": "ciliated left-right organizer metallopeptidase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cirop"
      }
    ]
  }
}