{
  "url": "https://dantelabs.com/traits/irregular-tarsal-ossification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "irregular-tarsal-ossification",
    "id": "HP:0008134",
    "name": "Irregular ankle bone maturation",
    "label": "Irregular tarsal ossification",
    "definition": "Defective ossification in an irregular pattern of the seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.",
    "synonyms": [
      "Irregular tarsal centers",
      "Irregular tarsal centres"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-tarsal-ossification",
        "name": "Abnormal maturation of ankle bones",
        "url": "https://dantelabs.com/traits/abnormal-tarsal-ossification"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "eif2ak3",
        "symbol": "EIF2AK3",
        "hgnc": "HGNC:3255",
        "name": "eukaryotic translation initiation factor 2 alpha kinase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2ak3"
      }
    ]
  }
}