{
  "url": "https://dantelabs.com/traits/increased-csf-lactate",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-csf-lactate",
    "id": "HP:0002490",
    "name": "Increased CSF lactate",
    "definition": "Increased concentration of lactate in the cerebrospinal fluid.",
    "synonyms": [
      "Hyperlactatorachia",
      "Increased cerebrospinal fluid lactate",
      "Increased CSF lactic acid"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-csf-lactate-concentration",
        "name": "Abnormal CSF lactate concentration",
        "url": "https://dantelabs.com/traits/abnormal-csf-lactate-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aifm1"
      },
      {
        "slug": "atp5po",
        "symbol": "ATP5PO",
        "hgnc": "HGNC:850",
        "name": "ATP synthase peripheral stalk subunit OSCP",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5po"
      },
      {
        "slug": "atpaf2",
        "symbol": "ATPAF2",
        "hgnc": "HGNC:18802",
        "name": "ATP synthase mitochondrial F1 complex assembly factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atpaf2"
      },
      {
        "slug": "clpb",
        "symbol": "CLPB",
        "hgnc": "HGNC:30664",
        "name": "ClpB family mitochondrial disaggregase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clpb"
      },
      {
        "slug": "cox10",
        "symbol": "COX10",
        "hgnc": "HGNC:2260",
        "name": "cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cox10"
      },
      {
        "slug": "cox14",
        "symbol": "COX14",
        "hgnc": "HGNC:28216",
        "name": "cytochrome c oxidase assembly factor COX14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox14"
      },
      {
        "slug": "cox20",
        "symbol": "COX20",
        "hgnc": "HGNC:26970",
        "name": "cytochrome c oxidase assembly factor COX20",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox20"
      },
      {
        "slug": "cox4i1",
        "symbol": "COX4I1",
        "hgnc": "HGNC:2265",
        "name": "cytochrome c oxidase subunit 4I1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox4i1"
      },
      {
        "slug": "cox8a",
        "symbol": "COX8A",
        "hgnc": "HGNC:2294",
        "name": "cytochrome c oxidase subunit 8A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox8a"
      },
      {
        "slug": "coxfa4",
        "symbol": "COXFA4",
        "hgnc": "HGNC:7687",
        "name": "cytochrome c oxidase associated subunit FA4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coxfa4"
      },
      {
        "slug": "echs1",
        "symbol": "ECHS1",
        "hgnc": "HGNC:3151",
        "name": "enoyl-CoA hydratase, short chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/echs1"
      },
      {
        "slug": "fastkd5",
        "symbol": "FASTKD5",
        "hgnc": "HGNC:25790",
        "name": "FASTK mitochondrial RNA regulator 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fastkd5"
      },
      {
        "slug": "fdxr",
        "symbol": "FDXR",
        "hgnc": "HGNC:3642",
        "name": "ferredoxin reductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdxr"
      },
      {
        "slug": "iba57",
        "symbol": "IBA57",
        "hgnc": "HGNC:27302",
        "name": "iron-sulfur cluster assembly factor IBA57",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/iba57"
      },
      {
        "slug": "lrpprc",
        "symbol": "LRPPRC",
        "hgnc": "HGNC:15714",
        "name": "leucine rich pentatricopeptide repeat containing",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lrpprc"
      },
      {
        "slug": "lyrm7",
        "symbol": "LYRM7",
        "hgnc": "HGNC:28072",
        "name": "LYR motif containing 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyrm7"
      },
      {
        "slug": "mdh2",
        "symbol": "MDH2",
        "hgnc": "HGNC:6971",
        "name": "malate dehydrogenase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdh2"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "mtfmt",
        "symbol": "MTFMT",
        "hgnc": "HGNC:29666",
        "name": "mitochondrial methionyl-tRNA formyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtfmt"
      },
      {
        "slug": "nadk2",
        "symbol": "NADK2",
        "hgnc": "HGNC:26404",
        "name": "NAD kinase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nadk2"
      },
      {
        "slug": "naxe",
        "symbol": "NAXE",
        "hgnc": "HGNC:18453",
        "name": "NAD(P)HX epimerase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/naxe"
      },
      {
        "slug": "ndufa10",
        "symbol": "NDUFA10",
        "hgnc": "HGNC:7684",
        "name": "NADH:ubiquinone oxidoreductase subunit A10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa10"
      },
      {
        "slug": "ndufa12",
        "symbol": "NDUFA12",
        "hgnc": "HGNC:23987",
        "name": "NADH:ubiquinone oxidoreductase subunit A12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa12"
      },
      {
        "slug": "ndufa8",
        "symbol": "NDUFA8",
        "hgnc": "HGNC:7692",
        "name": "NADH:ubiquinone oxidoreductase subunit A8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa8"
      },
      {
        "slug": "ndufaf2",
        "symbol": "NDUFAF2",
        "hgnc": "HGNC:28086",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf2"
      },
      {
        "slug": "ndufaf3",
        "symbol": "NDUFAF3",
        "hgnc": "HGNC:29918",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf3"
      },
      {
        "slug": "ndufaf5",
        "symbol": "NDUFAF5",
        "hgnc": "HGNC:15899",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf5"
      },
      {
        "slug": "ndufb8",
        "symbol": "NDUFB8",
        "hgnc": "HGNC:7703",
        "name": "NADH:ubiquinone oxidoreductase subunit B8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb8"
      },
      {
        "slug": "ndufs1",
        "symbol": "NDUFS1",
        "hgnc": "HGNC:7707",
        "name": "NADH:ubiquinone oxidoreductase core subunit S1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufs1"
      },
      {
        "slug": "ndufs3",
        "symbol": "NDUFS3",
        "hgnc": "HGNC:7710",
        "name": "NADH:ubiquinone oxidoreductase core subunit S3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufs3"
      },
      {
        "slug": "ndufs4",
        "symbol": "NDUFS4",
        "hgnc": "HGNC:7711",
        "name": "NADH:ubiquinone oxidoreductase subunit S4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufs4"
      },
      {
        "slug": "ndufv1",
        "symbol": "NDUFV1",
        "hgnc": "HGNC:7716",
        "name": "NADH:ubiquinone oxidoreductase core subunit V1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufv1"
      },
      {
        "slug": "nfu1",
        "symbol": "NFU1",
        "hgnc": "HGNC:16287",
        "name": "NFU1 iron-sulfur cluster scaffold",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nfu1"
      },
      {
        "slug": "nubpl",
        "symbol": "NUBPL",
        "hgnc": "HGNC:20278",
        "name": "NUBP iron-sulfur cluster assembly factor, mitochondrial",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nubpl"
      },
      {
        "slug": "opa1",
        "symbol": "OPA1",
        "hgnc": "HGNC:8140",
        "name": "OPA1 mitochondrial dynamin like GTPase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/opa1"
      },
      {
        "slug": "pdha1",
        "symbol": "PDHA1",
        "hgnc": "HGNC:8806",
        "name": "pyruvate dehydrogenase E1 subunit alpha 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdha1"
      },
      {
        "slug": "pet100",
        "symbol": "PET100",
        "hgnc": "HGNC:40038",
        "name": "PET100 cytochrome c oxidase chaperone",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pet100"
      },
      {
        "slug": "pet117",
        "symbol": "PET117",
        "hgnc": "HGNC:40045",
        "name": "PET117 cytochrome c oxidase chaperone",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pet117"
      },
      {
        "slug": "pnpt1",
        "symbol": "PNPT1",
        "hgnc": "HGNC:23166",
        "name": "polyribonucleotide nucleotidyltransferase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pnpt1"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "slc25a19",
        "symbol": "SLC25A19",
        "hgnc": "HGNC:14409",
        "name": "solute carrier family 25 member 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a19"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "slc31a1",
        "symbol": "SLC31A1",
        "hgnc": "HGNC:11016",
        "name": "solute carrier family 31 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc31a1"
      },
      {
        "slug": "sucla2",
        "symbol": "SUCLA2",
        "hgnc": "HGNC:11448",
        "name": "succinate-CoA ligase ADP-forming subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sucla2"
      },
      {
        "slug": "suclg1",
        "symbol": "SUCLG1",
        "hgnc": "HGNC:11449",
        "name": "succinate-CoA ligase GDP/ADP-forming subunit alpha",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/suclg1"
      },
      {
        "slug": "timm50",
        "symbol": "TIMM50",
        "hgnc": "HGNC:23656",
        "name": "translocase of inner mitochondrial membrane 50",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/timm50"
      },
      {
        "slug": "trmt10c",
        "symbol": "TRMT10C",
        "hgnc": "HGNC:26022",
        "name": "tRNA methyltransferase 10C, mitochondrial RNase P subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt10c"
      },
      {
        "slug": "uqcc2",
        "symbol": "UQCC2",
        "hgnc": "HGNC:21237",
        "name": "ubiquinol-cytochrome c reductase complex assembly factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcc2"
      },
      {
        "slug": "uqcc3",
        "symbol": "UQCC3",
        "hgnc": "HGNC:34399",
        "name": "ubiquinol-cytochrome c reductase complex assembly factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcc3"
      },
      {
        "slug": "foxred1",
        "symbol": "FOXRED1",
        "hgnc": "HGNC:26927",
        "name": "FAD dependent oxidoreductase domain containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxred1"
      },
      {
        "slug": "hsd17b10",
        "symbol": "HSD17B10",
        "hgnc": "HGNC:4800",
        "name": "hydroxysteroid 17-beta dehydrogenase 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd17b10"
      },
      {
        "slug": "iars2",
        "symbol": "IARS2",
        "hgnc": "HGNC:29685",
        "name": "isoleucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iars2"
      },
      {
        "slug": "lonp1",
        "symbol": "LONP1",
        "hgnc": "HGNC:9479",
        "name": "lon peptidase 1, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lonp1"
      },
      {
        "slug": "mt-atp6",
        "symbol": "MT-ATP6",
        "hgnc": "HGNC:7414",
        "name": "mitochondrially encoded ATP synthase membrane subunit 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-atp6"
      },
      {
        "slug": "mt-nd1",
        "symbol": "MT-ND1",
        "hgnc": "HGNC:7455",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mt-nd1"
      },
      {
        "slug": "mt-nd2",
        "symbol": "MT-ND2",
        "hgnc": "HGNC:7456",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd2"
      },
      {
        "slug": "mt-nd3",
        "symbol": "MT-ND3",
        "hgnc": "HGNC:7458",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd3"
      },
      {
        "slug": "mt-nd4",
        "symbol": "MT-ND4",
        "hgnc": "HGNC:7459",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd4"
      },
      {
        "slug": "mt-nd5",
        "symbol": "MT-ND5",
        "hgnc": "HGNC:7461",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd5"
      },
      {
        "slug": "mt-nd6",
        "symbol": "MT-ND6",
        "hgnc": "HGNC:7462",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd6"
      },
      {
        "slug": "mt-tk",
        "symbol": "MT-TK",
        "hgnc": "HGNC:7489",
        "name": "mitochondrially encoded tRNA-Lys (AAA/G)",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tk"
      },
      {
        "slug": "mt-tl1",
        "symbol": "MT-TL1",
        "hgnc": "HGNC:7490",
        "name": "mitochondrially encoded tRNA-Leu (UUA/G) 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mt-tl1"
      },
      {
        "slug": "mt-tv",
        "symbol": "MT-TV",
        "hgnc": "HGNC:7500",
        "name": "mitochondrially encoded tRNA-Val (GUN)",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tv"
      },
      {
        "slug": "mt-tw",
        "symbol": "MT-TW",
        "hgnc": "HGNC:7501",
        "name": "mitochondrially encoded tRNA-Trp (UGA/G)",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tw"
      },
      {
        "slug": "ndufa1",
        "symbol": "NDUFA1",
        "hgnc": "HGNC:7683",
        "name": "NADH:ubiquinone oxidoreductase subunit A1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa1"
      },
      {
        "slug": "ndufa11",
        "symbol": "NDUFA11",
        "hgnc": "HGNC:20371",
        "name": "NADH:ubiquinone oxidoreductase subunit A11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa11"
      },
      {
        "slug": "ndufa6",
        "symbol": "NDUFA6",
        "hgnc": "HGNC:7690",
        "name": "NADH:ubiquinone oxidoreductase subunit A6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufa6"
      },
      {
        "slug": "ndufa9",
        "symbol": "NDUFA9",
        "hgnc": "HGNC:7693",
        "name": "NADH:ubiquinone oxidoreductase subunit A9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa9"
      },
      {
        "slug": "ndufaf1",
        "symbol": "NDUFAF1",
        "hgnc": "HGNC:18828",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf1"
      },
      {
        "slug": "ndufaf4",
        "symbol": "NDUFAF4",
        "hgnc": "HGNC:21034",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf4"
      },
      {
        "slug": "ndufaf8",
        "symbol": "NDUFAF8",
        "hgnc": "HGNC:33551",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf8"
      },
      {
        "slug": "ndufb10",
        "symbol": "NDUFB10",
        "hgnc": "HGNC:7696",
        "name": "NADH:ubiquinone oxidoreductase subunit B10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb10"
      },
      {
        "slug": "ndufb11",
        "symbol": "NDUFB11",
        "hgnc": "HGNC:20372",
        "name": "NADH:ubiquinone oxidoreductase subunit B11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb11"
      },
      {
        "slug": "ndufb3",
        "symbol": "NDUFB3",
        "hgnc": "HGNC:7698",
        "name": "NADH:ubiquinone oxidoreductase subunit B3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb3"
      },
      {
        "slug": "ndufb9",
        "symbol": "NDUFB9",
        "hgnc": "HGNC:7704",
        "name": "NADH:ubiquinone oxidoreductase subunit B9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb9"
      },
      {
        "slug": "ndufs2",
        "symbol": "NDUFS2",
        "hgnc": "HGNC:7708",
        "name": "NADH:ubiquinone oxidoreductase core subunit S2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs2"
      },
      {
        "slug": "ndufs6",
        "symbol": "NDUFS6",
        "hgnc": "HGNC:7713",
        "name": "NADH:ubiquinone oxidoreductase subunit S6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs6"
      },
      {
        "slug": "ndufs7",
        "symbol": "NDUFS7",
        "hgnc": "HGNC:7714",
        "name": "NADH:ubiquinone oxidoreductase core subunit S7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs7"
      },
      {
        "slug": "ndufs8",
        "symbol": "NDUFS8",
        "hgnc": "HGNC:7715",
        "name": "NADH:ubiquinone oxidoreductase core subunit S8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs8"
      },
      {
        "slug": "ndufv2",
        "symbol": "NDUFV2",
        "hgnc": "HGNC:7717",
        "name": "NADH:ubiquinone oxidoreductase core subunit V2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufv2"
      },
      {
        "slug": "pdhx",
        "symbol": "PDHX",
        "hgnc": "HGNC:21350",
        "name": "pyruvate dehydrogenase complex component X",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdhx"
      },
      {
        "slug": "timmdc1",
        "symbol": "TIMMDC1",
        "hgnc": "HGNC:1321",
        "name": "translocase of inner mitochondrial membrane domain containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/timmdc1"
      },
      {
        "slug": "tmem126b",
        "symbol": "TMEM126B",
        "hgnc": "HGNC:30883",
        "name": "transmembrane protein 126B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem126b"
      },
      {
        "slug": "txn2",
        "symbol": "TXN2",
        "hgnc": "HGNC:17772",
        "name": "thioredoxin 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/txn2"
      },
      {
        "slug": "coa8",
        "symbol": "COA8",
        "hgnc": "HGNC:20492",
        "name": "cytochrome c oxidase assembly factor 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa8"
      },
      {
        "slug": "coq8a",
        "symbol": "COQ8A",
        "hgnc": "HGNC:16812",
        "name": "coenzyme Q8A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/coq8a"
      },
      {
        "slug": "cox11",
        "symbol": "COX11",
        "hgnc": "HGNC:2261",
        "name": "cytochrome c oxidase copper chaperone COX11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox11"
      },
      {
        "slug": "dnm1l",
        "symbol": "DNM1L",
        "hgnc": "HGNC:2973",
        "name": "dynamin 1L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm1l"
      },
      {
        "slug": "fars2",
        "symbol": "FARS2",
        "hgnc": "HGNC:21062",
        "name": "phenylalanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fars2"
      },
      {
        "slug": "gfm2",
        "symbol": "GFM2",
        "hgnc": "HGNC:29682",
        "name": "GTP dependent ribosome recycling factor mitochondrial 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gfm2"
      },
      {
        "slug": "hmbs",
        "symbol": "HMBS",
        "hgnc": "HGNC:4982",
        "name": "hydroxymethylbilane synthase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmbs"
      },
      {
        "slug": "hpdl",
        "symbol": "HPDL",
        "hgnc": "HGNC:28242",
        "name": "4-hydroxyphenylpyruvate dioxygenase like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpdl"
      },
      {
        "slug": "lyrm4",
        "symbol": "LYRM4",
        "hgnc": "HGNC:21365",
        "name": "LYR motif containing 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyrm4"
      },
      {
        "slug": "mrps34",
        "symbol": "MRPS34",
        "hgnc": "HGNC:16618",
        "name": "mitochondrial ribosomal protein S34",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps34"
      },
      {
        "slug": "mt-co1",
        "symbol": "MT-CO1",
        "hgnc": "HGNC:7419",
        "name": "mitochondrially encoded cytochrome c oxidase I",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co1"
      },
      {
        "slug": "mt-co2",
        "symbol": "MT-CO2",
        "hgnc": "HGNC:7421",
        "name": "mitochondrially encoded cytochrome c oxidase II",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co2"
      },
      {
        "slug": "mt-co3",
        "symbol": "MT-CO3",
        "hgnc": "HGNC:7422",
        "name": "mitochondrially encoded cytochrome c oxidase III",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co3"
      },
      {
        "slug": "mt-tf",
        "symbol": "MT-TF",
        "hgnc": "HGNC:7481",
        "name": "mitochondrially encoded tRNA-Phe (UUU/C)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tf"
      },
      {
        "slug": "mt-th",
        "symbol": "MT-TH",
        "hgnc": "HGNC:7487",
        "name": "mitochondrially encoded tRNA-His (CAU/C)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-th"
      },
      {
        "slug": "mt-tq",
        "symbol": "MT-TQ",
        "hgnc": "HGNC:7495",
        "name": "mitochondrially encoded tRNA-Gln (CAA/G)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tq"
      },
      {
        "slug": "mt-ts1",
        "symbol": "MT-TS1",
        "hgnc": "HGNC:7497",
        "name": "mitochondrially encoded tRNA-Ser (UCN) 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-ts1"
      },
      {
        "slug": "mt-ts2",
        "symbol": "MT-TS2",
        "hgnc": "HGNC:7498",
        "name": "mitochondrially encoded tRNA-Ser (AGU/C) 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-ts2"
      },
      {
        "slug": "naxd",
        "symbol": "NAXD",
        "hgnc": "HGNC:25576",
        "name": "NAD(P)HX dehydratase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naxd"
      },
      {
        "slug": "rars2",
        "symbol": "RARS2",
        "hgnc": "HGNC:21406",
        "name": "arginyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rars2"
      },
      {
        "slug": "slc13a3",
        "symbol": "SLC13A3",
        "hgnc": "HGNC:14430",
        "name": "solute carrier family 13 member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc13a3"
      },
      {
        "slug": "slc2a1",
        "symbol": "SLC2A1",
        "hgnc": "HGNC:11005",
        "name": "solute carrier family 2 member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a1"
      },
      {
        "slug": "tpk1",
        "symbol": "TPK1",
        "hgnc": "HGNC:17358",
        "name": "thiamin pyrophosphokinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpk1"
      },
      {
        "slug": "aldh4a1",
        "symbol": "ALDH4A1",
        "hgnc": "HGNC:406",
        "name": "aldehyde dehydrogenase 4 family member A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh4a1"
      },
      {
        "slug": "bola3",
        "symbol": "BOLA3",
        "hgnc": "HGNC:24415",
        "name": "bolA family member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bola3"
      },
      {
        "slug": "dars2",
        "symbol": "DARS2",
        "hgnc": "HGNC:25538",
        "name": "aspartyl-tRNA synthetase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dars2"
      },
      {
        "slug": "glrx5",
        "symbol": "GLRX5",
        "hgnc": "HGNC:20134",
        "name": "glutaredoxin 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glrx5"
      },
      {
        "slug": "isca2",
        "symbol": "ISCA2",
        "hgnc": "HGNC:19857",
        "name": "iron-sulfur cluster assembly 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/isca2"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "slc39a8",
        "symbol": "SLC39A8",
        "hgnc": "HGNC:20862",
        "name": "solute carrier family 39 member 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc39a8"
      },
      {
        "slug": "trappc12",
        "symbol": "TRAPPC12",
        "hgnc": "HGNC:24284",
        "name": "trafficking protein particle complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc12"
      },
      {
        "slug": "cox15",
        "symbol": "COX15",
        "hgnc": "HGNC:2263",
        "name": "cytochrome c oxidase assembly factor COX15",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox15"
      },
      {
        "slug": "cox6b1",
        "symbol": "COX6B1",
        "hgnc": "HGNC:2280",
        "name": "cytochrome c oxidase subunit 6B1",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cox6b1"
      },
      {
        "slug": "fastkd2",
        "symbol": "FASTKD2",
        "hgnc": "HGNC:29160",
        "name": "FASTK mitochondrial RNA regulator 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fastkd2"
      },
      {
        "slug": "gfm1",
        "symbol": "GFM1",
        "hgnc": "HGNC:13780",
        "name": "G elongation factor mitochondrial 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfm1"
      },
      {
        "slug": "htra2",
        "symbol": "HTRA2",
        "hgnc": "HGNC:14348",
        "name": "HtrA serine peptidase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htra2"
      },
      {
        "slug": "mt-tn",
        "symbol": "MT-TN",
        "hgnc": "HGNC:7493",
        "name": "mitochondrially encoded tRNA-Asn (AAU/C)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tn"
      },
      {
        "slug": "nars2",
        "symbol": "NARS2",
        "hgnc": "HGNC:26274",
        "name": "asparaginyl-tRNA synthetase 2, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nars2"
      },
      {
        "slug": "rmnd1",
        "symbol": "RMND1",
        "hgnc": "HGNC:21176",
        "name": "required for meiotic nuclear division 1 homolog",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmnd1"
      },
      {
        "slug": "sco1",
        "symbol": "SCO1",
        "hgnc": "HGNC:10603",
        "name": "synthesis of cytochrome C oxidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco1"
      },
      {
        "slug": "surf1",
        "symbol": "SURF1",
        "hgnc": "HGNC:11474",
        "name": "SURF1 cytochrome c oxidase assembly factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/surf1"
      },
      {
        "slug": "taco1",
        "symbol": "TACO1",
        "hgnc": "HGNC:24316",
        "name": "translational activator of cytochrome c oxidase I",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taco1"
      }
    ]
  }
}