{
  "url": "https://dantelabs.com/traits/increased-circulating-lactate-concentration",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "increased-circulating-lactate-concentration",
    "id": "HP:0002151",
    "name": "Higher than normal levels of lactate in blood",
    "label": "Increased circulating lactate concentration",
    "definition": "Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35).",
    "synonyms": [
      "Increased blood lactate",
      "Increased serum lactate"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "acidosis",
        "name": "Acidosis",
        "url": "https://dantelabs.com/traits/acidosis"
      }
    ],
    "narrower": [
      {
        "slug": "postprandial-hyperlactemia",
        "name": "Postprandial hyperlactemia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/postprandial-hyperlactemia"
      }
    ],
    "genes": [
      {
        "slug": "acaca",
        "symbol": "ACACA",
        "hgnc": "HGNC:84",
        "name": "acetyl-CoA carboxylase alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acaca"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aifm1"
      },
      {
        "slug": "aldh6a1",
        "symbol": "ALDH6A1",
        "hgnc": "HGNC:7179",
        "name": "aldehyde dehydrogenase 6 family member A1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh6a1"
      },
      {
        "slug": "atpaf2",
        "symbol": "ATPAF2",
        "hgnc": "HGNC:18802",
        "name": "ATP synthase mitochondrial F1 complex assembly factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atpaf2"
      },
      {
        "slug": "ca5a",
        "symbol": "CA5A",
        "hgnc": "HGNC:1377",
        "name": "carbonic anhydrase 5A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca5a"
      },
      {
        "slug": "cox10",
        "symbol": "COX10",
        "hgnc": "HGNC:2260",
        "name": "cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cox10"
      },
      {
        "slug": "cox11",
        "symbol": "COX11",
        "hgnc": "HGNC:2261",
        "name": "cytochrome c oxidase copper chaperone COX11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox11"
      },
      {
        "slug": "cox14",
        "symbol": "COX14",
        "hgnc": "HGNC:28216",
        "name": "cytochrome c oxidase assembly factor COX14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox14"
      },
      {
        "slug": "cox18",
        "symbol": "COX18",
        "hgnc": "HGNC:26801",
        "name": "cytochrome c oxidase assembly factor COX18",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox18"
      },
      {
        "slug": "cox20",
        "symbol": "COX20",
        "hgnc": "HGNC:26970",
        "name": "cytochrome c oxidase assembly factor COX20",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox20"
      },
      {
        "slug": "cox5a",
        "symbol": "COX5A",
        "hgnc": "HGNC:2267",
        "name": "cytochrome c oxidase subunit 5A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox5a"
      },
      {
        "slug": "cox6a2",
        "symbol": "COX6A2",
        "hgnc": "HGNC:2279",
        "name": "cytochrome c oxidase subunit 6A2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox6a2"
      },
      {
        "slug": "cox6b1",
        "symbol": "COX6B1",
        "hgnc": "HGNC:2280",
        "name": "cytochrome c oxidase subunit 6B1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cox6b1"
      },
      {
        "slug": "cox8a",
        "symbol": "COX8A",
        "hgnc": "HGNC:2294",
        "name": "cytochrome c oxidase subunit 8A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox8a"
      },
      {
        "slug": "cyc1",
        "symbol": "CYC1",
        "hgnc": "HGNC:2579",
        "name": "cytochrome c1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyc1"
      },
      {
        "slug": "dtymk",
        "symbol": "DTYMK",
        "hgnc": "HGNC:3061",
        "name": "deoxythymidylate kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dtymk"
      },
      {
        "slug": "echs1",
        "symbol": "ECHS1",
        "hgnc": "HGNC:3151",
        "name": "enoyl-CoA hydratase, short chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/echs1"
      },
      {
        "slug": "fars2",
        "symbol": "FARS2",
        "hgnc": "HGNC:21062",
        "name": "phenylalanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fars2"
      },
      {
        "slug": "fastkd5",
        "symbol": "FASTKD5",
        "hgnc": "HGNC:25790",
        "name": "FASTK mitochondrial RNA regulator 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fastkd5"
      },
      {
        "slug": "fbxl4",
        "symbol": "FBXL4",
        "hgnc": "HGNC:13601",
        "name": "F-box and leucine rich repeat protein 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxl4"
      },
      {
        "slug": "fdx2",
        "symbol": "FDX2",
        "hgnc": "HGNC:30546",
        "name": "ferredoxin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdx2"
      },
      {
        "slug": "gk",
        "symbol": "GK",
        "hgnc": "HGNC:4289",
        "name": "glycerol kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gk"
      },
      {
        "slug": "got2",
        "symbol": "GOT2",
        "hgnc": "HGNC:4433",
        "name": "glutamic-oxaloacetic transaminase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/got2"
      },
      {
        "slug": "gtpbp3",
        "symbol": "GTPBP3",
        "hgnc": "HGNC:14880",
        "name": "GTP binding protein 3, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtpbp3"
      },
      {
        "slug": "hadhb",
        "symbol": "HADHB",
        "hgnc": "HGNC:4803",
        "name": "hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadhb"
      },
      {
        "slug": "hs6st2",
        "symbol": "HS6ST2",
        "hgnc": "HGNC:19133",
        "name": "heparan sulfate 6-O-sulfotransferase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hs6st2"
      },
      {
        "slug": "kars1",
        "symbol": "KARS1",
        "hgnc": "HGNC:6215",
        "name": "lysyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kars1"
      },
      {
        "slug": "lars2",
        "symbol": "LARS2",
        "hgnc": "HGNC:17095",
        "name": "leucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars2"
      },
      {
        "slug": "lias",
        "symbol": "LIAS",
        "hgnc": "HGNC:16429",
        "name": "lipoic acid synthetase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lias"
      },
      {
        "slug": "lipt1",
        "symbol": "LIPT1",
        "hgnc": "HGNC:29569",
        "name": "lipoyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipt1"
      },
      {
        "slug": "lipt2",
        "symbol": "LIPT2",
        "hgnc": "HGNC:37216",
        "name": "lipoyl(octanoyl) transferase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipt2"
      },
      {
        "slug": "lrpprc",
        "symbol": "LRPPRC",
        "hgnc": "HGNC:15714",
        "name": "leucine rich pentatricopeptide repeat containing",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lrpprc"
      },
      {
        "slug": "lyrm7",
        "symbol": "LYRM7",
        "hgnc": "HGNC:28072",
        "name": "LYR motif containing 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyrm7"
      },
      {
        "slug": "mdh2",
        "symbol": "MDH2",
        "hgnc": "HGNC:6971",
        "name": "malate dehydrogenase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdh2"
      },
      {
        "slug": "micos13",
        "symbol": "MICOS13",
        "hgnc": "HGNC:33702",
        "name": "mitochondrial contact site and cristae organizing system subunit 13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/micos13"
      },
      {
        "slug": "mipep",
        "symbol": "MIPEP",
        "hgnc": "HGNC:7104",
        "name": "mitochondrial intermediate peptidase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mipep"
      },
      {
        "slug": "mrpl12",
        "symbol": "MRPL12",
        "hgnc": "HGNC:10378",
        "name": "mitochondrial ribosomal protein L12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrpl12"
      },
      {
        "slug": "mrpl3",
        "symbol": "MRPL3",
        "hgnc": "HGNC:10379",
        "name": "mitochondrial ribosomal protein L3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrpl3"
      },
      {
        "slug": "mrps14",
        "symbol": "MRPS14",
        "hgnc": "HGNC:14049",
        "name": "mitochondrial ribosomal protein S14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps14"
      },
      {
        "slug": "mrps16",
        "symbol": "MRPS16",
        "hgnc": "HGNC:14048",
        "name": "mitochondrial ribosomal protein S16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps16"
      },
      {
        "slug": "mrps2",
        "symbol": "MRPS2",
        "hgnc": "HGNC:14495",
        "name": "mitochondrial ribosomal protein S2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps2"
      },
      {
        "slug": "mrps28",
        "symbol": "MRPS28",
        "hgnc": "HGNC:14513",
        "name": "mitochondrial ribosomal protein S28",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps28"
      },
      {
        "slug": "mrps34",
        "symbol": "MRPS34",
        "hgnc": "HGNC:16618",
        "name": "mitochondrial ribosomal protein S34",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps34"
      },
      {
        "slug": "mrps7",
        "symbol": "MRPS7",
        "hgnc": "HGNC:14499",
        "name": "mitochondrial ribosomal protein S7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps7"
      },
      {
        "slug": "mto1",
        "symbol": "MTO1",
        "hgnc": "HGNC:19261",
        "name": "mitochondrial tRNA translation optimization 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mto1"
      },
      {
        "slug": "mtrfr",
        "symbol": "MTRFR",
        "hgnc": "HGNC:26784",
        "name": "mitochondrial translation release factor in rescue",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtrfr"
      },
      {
        "slug": "nadk2",
        "symbol": "NADK2",
        "hgnc": "HGNC:26404",
        "name": "NAD kinase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nadk2"
      },
      {
        "slug": "naxe",
        "symbol": "NAXE",
        "hgnc": "HGNC:18453",
        "name": "NAD(P)HX epimerase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naxe"
      },
      {
        "slug": "ndufa11",
        "symbol": "NDUFA11",
        "hgnc": "HGNC:20371",
        "name": "NADH:ubiquinone oxidoreductase subunit A11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa11"
      },
      {
        "slug": "ndufa12",
        "symbol": "NDUFA12",
        "hgnc": "HGNC:23987",
        "name": "NADH:ubiquinone oxidoreductase subunit A12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa12"
      },
      {
        "slug": "ndufa13",
        "symbol": "NDUFA13",
        "hgnc": "HGNC:17194",
        "name": "NADH:ubiquinone oxidoreductase subunit A13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa13"
      },
      {
        "slug": "ndufa8",
        "symbol": "NDUFA8",
        "hgnc": "HGNC:7692",
        "name": "NADH:ubiquinone oxidoreductase subunit A8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa8"
      },
      {
        "slug": "ndufa9",
        "symbol": "NDUFA9",
        "hgnc": "HGNC:7693",
        "name": "NADH:ubiquinone oxidoreductase subunit A9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa9"
      },
      {
        "slug": "ndufaf4",
        "symbol": "NDUFAF4",
        "hgnc": "HGNC:21034",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf4"
      },
      {
        "slug": "ndufaf6",
        "symbol": "NDUFAF6",
        "hgnc": "HGNC:28625",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf6"
      },
      {
        "slug": "ndufb8",
        "symbol": "NDUFB8",
        "hgnc": "HGNC:7703",
        "name": "NADH:ubiquinone oxidoreductase subunit B8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb8"
      },
      {
        "slug": "ndufb9",
        "symbol": "NDUFB9",
        "hgnc": "HGNC:7704",
        "name": "NADH:ubiquinone oxidoreductase subunit B9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb9"
      },
      {
        "slug": "ndufc2",
        "symbol": "NDUFC2",
        "hgnc": "HGNC:7706",
        "name": "NADH:ubiquinone oxidoreductase subunit C2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufc2"
      },
      {
        "slug": "ndufs1",
        "symbol": "NDUFS1",
        "hgnc": "HGNC:7707",
        "name": "NADH:ubiquinone oxidoreductase core subunit S1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs1"
      },
      {
        "slug": "ndufs8",
        "symbol": "NDUFS8",
        "hgnc": "HGNC:7715",
        "name": "NADH:ubiquinone oxidoreductase core subunit S8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs8"
      },
      {
        "slug": "nfs1",
        "symbol": "NFS1",
        "hgnc": "HGNC:15910",
        "name": "NFS1 cysteine desulfurase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfs1"
      },
      {
        "slug": "nfu1",
        "symbol": "NFU1",
        "hgnc": "HGNC:16287",
        "name": "NFU1 iron-sulfur cluster scaffold",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nfu1"
      },
      {
        "slug": "nsun3",
        "symbol": "NSUN3",
        "hgnc": "HGNC:26208",
        "name": "NOP2/Sun RNA methyltransferase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsun3"
      },
      {
        "slug": "ogdh",
        "symbol": "OGDH",
        "hgnc": "HGNC:8124",
        "name": "oxoglutarate dehydrogenase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ogdh"
      },
      {
        "slug": "opa1",
        "symbol": "OPA1",
        "hgnc": "HGNC:8140",
        "name": "OPA1 mitochondrial dynamin like GTPase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/opa1"
      },
      {
        "slug": "pdha1",
        "symbol": "PDHA1",
        "hgnc": "HGNC:8806",
        "name": "pyruvate dehydrogenase E1 subunit alpha 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdha1"
      },
      {
        "slug": "pdss1",
        "symbol": "PDSS1",
        "hgnc": "HGNC:17759",
        "name": "decaprenyl diphosphate synthase subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdss1"
      },
      {
        "slug": "pdss2",
        "symbol": "PDSS2",
        "hgnc": "HGNC:23041",
        "name": "decaprenyl diphosphate synthase subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdss2"
      },
      {
        "slug": "pet100",
        "symbol": "PET100",
        "hgnc": "HGNC:40038",
        "name": "PET100 cytochrome c oxidase chaperone",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pet100"
      },
      {
        "slug": "pet117",
        "symbol": "PET117",
        "hgnc": "HGNC:40045",
        "name": "PET117 cytochrome c oxidase chaperone",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pet117"
      },
      {
        "slug": "pnpla8",
        "symbol": "PNPLA8",
        "hgnc": "HGNC:28900",
        "name": "patatin like domain 8, phospholipase A2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnpla8"
      },
      {
        "slug": "pnpt1",
        "symbol": "PNPT1",
        "hgnc": "HGNC:23166",
        "name": "polyribonucleotide nucleotidyltransferase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pnpt1"
      },
      {
        "slug": "polg2",
        "symbol": "POLG2",
        "hgnc": "HGNC:9180",
        "name": "DNA polymerase gamma 2, accessory subunit",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/polg2"
      },
      {
        "slug": "rmnd1",
        "symbol": "RMND1",
        "hgnc": "HGNC:21176",
        "name": "required for meiotic nuclear division 1 homolog",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmnd1"
      },
      {
        "slug": "rragc",
        "symbol": "RRAGC",
        "hgnc": "HGNC:19902",
        "name": "Ras related GTP binding C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rragc"
      },
      {
        "slug": "sars2",
        "symbol": "SARS2",
        "hgnc": "HGNC:17697",
        "name": "seryl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sars2"
      },
      {
        "slug": "sco1",
        "symbol": "SCO1",
        "hgnc": "HGNC:10603",
        "name": "synthesis of cytochrome C oxidase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sco1"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sdhb",
        "symbol": "SDHB",
        "hgnc": "HGNC:10681",
        "name": "succinate dehydrogenase complex iron sulfur subunit B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhb"
      },
      {
        "slug": "sfxn4",
        "symbol": "SFXN4",
        "hgnc": "HGNC:16088",
        "name": "sideroflexin 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sfxn4"
      },
      {
        "slug": "slc25a10",
        "symbol": "SLC25A10",
        "hgnc": "HGNC:10980",
        "name": "solute carrier family 25 member 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a10"
      },
      {
        "slug": "slc25a12",
        "symbol": "SLC25A12",
        "hgnc": "HGNC:10982",
        "name": "solute carrier family 25 member 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a12"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "slc25a42",
        "symbol": "SLC25A42",
        "hgnc": "HGNC:28380",
        "name": "solute carrier family 25 member 42",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a42"
      },
      {
        "slug": "slc31a1",
        "symbol": "SLC31A1",
        "hgnc": "HGNC:11016",
        "name": "solute carrier family 31 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc31a1"
      },
      {
        "slug": "sod1",
        "symbol": "SOD1",
        "hgnc": "HGNC:11179",
        "name": "superoxide dismutase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sod1"
      },
      {
        "slug": "tars2",
        "symbol": "TARS2",
        "hgnc": "HGNC:30740",
        "name": "threonyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tars2"
      },
      {
        "slug": "tefm",
        "symbol": "TEFM",
        "hgnc": "HGNC:26223",
        "name": "transcription elongation factor, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tefm"
      },
      {
        "slug": "timm22",
        "symbol": "TIMM22",
        "hgnc": "HGNC:17317",
        "name": "translocase of inner mitochondrial membrane 22",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/timm22"
      },
      {
        "slug": "tmem126b",
        "symbol": "TMEM126B",
        "hgnc": "HGNC:30883",
        "name": "transmembrane protein 126B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem126b"
      },
      {
        "slug": "trmt10c",
        "symbol": "TRMT10C",
        "hgnc": "HGNC:26022",
        "name": "tRNA methyltransferase 10C, mitochondrial RNase P subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt10c"
      },
      {
        "slug": "trmt5",
        "symbol": "TRMT5",
        "hgnc": "HGNC:23141",
        "name": "tRNA methyltransferase 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt5"
      },
      {
        "slug": "trmu",
        "symbol": "TRMU",
        "hgnc": "HGNC:25481",
        "name": "tRNA mitochondrial 2-thiouridylase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmu"
      },
      {
        "slug": "tsfm",
        "symbol": "TSFM",
        "hgnc": "HGNC:12367",
        "name": "Ts translation elongation factor, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsfm"
      },
      {
        "slug": "uqcc2",
        "symbol": "UQCC2",
        "hgnc": "HGNC:21237",
        "name": "ubiquinol-cytochrome c reductase complex assembly factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcc2"
      },
      {
        "slug": "uqcc3",
        "symbol": "UQCC3",
        "hgnc": "HGNC:34399",
        "name": "ubiquinol-cytochrome c reductase complex assembly factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcc3"
      },
      {
        "slug": "uqcrb",
        "symbol": "UQCRB",
        "hgnc": "HGNC:12582",
        "name": "ubiquinol-cytochrome c reductase binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcrb"
      },
      {
        "slug": "uqcrc2",
        "symbol": "UQCRC2",
        "hgnc": "HGNC:12586",
        "name": "ubiquinol-cytochrome c reductase core protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcrc2"
      },
      {
        "slug": "uqcrh",
        "symbol": "UQCRH",
        "hgnc": "HGNC:12590",
        "name": "ubiquinol-cytochrome c reductase hinge protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcrh"
      },
      {
        "slug": "uqcrq",
        "symbol": "UQCRQ",
        "hgnc": "HGNC:29594",
        "name": "ubiquinol-cytochrome c reductase complex III subunit VII",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcrq"
      },
      {
        "slug": "yars1",
        "symbol": "YARS1",
        "hgnc": "HGNC:12840",
        "name": "tyrosyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yars1"
      },
      {
        "slug": "yars2",
        "symbol": "YARS2",
        "hgnc": "HGNC:24249",
        "name": "tyrosyl-tRNA synthetase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yars2"
      },
      {
        "slug": "atad3a",
        "symbol": "ATAD3A",
        "hgnc": "HGNC:25567",
        "name": "ATPase family AAA domain containing 3A",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/atad3a"
      },
      {
        "slug": "coq4",
        "symbol": "COQ4",
        "hgnc": "HGNC:19693",
        "name": "coenzyme Q4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq4"
      },
      {
        "slug": "dld",
        "symbol": "DLD",
        "hgnc": "HGNC:2898",
        "name": "dihydrolipoamide dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dld"
      },
      {
        "slug": "hsd17b10",
        "symbol": "HSD17B10",
        "hgnc": "HGNC:4800",
        "name": "hydroxysteroid 17-beta dehydrogenase 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd17b10"
      },
      {
        "slug": "iars2",
        "symbol": "IARS2",
        "hgnc": "HGNC:29685",
        "name": "isoleucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iars2"
      },
      {
        "slug": "lonp1",
        "symbol": "LONP1",
        "hgnc": "HGNC:9479",
        "name": "lon peptidase 1, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lonp1"
      },
      {
        "slug": "mt-co1",
        "symbol": "MT-CO1",
        "hgnc": "HGNC:7419",
        "name": "mitochondrially encoded cytochrome c oxidase I",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co1"
      },
      {
        "slug": "mt-co2",
        "symbol": "MT-CO2",
        "hgnc": "HGNC:7421",
        "name": "mitochondrially encoded cytochrome c oxidase II",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co2"
      },
      {
        "slug": "mt-co3",
        "symbol": "MT-CO3",
        "hgnc": "HGNC:7422",
        "name": "mitochondrially encoded cytochrome c oxidase III",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co3"
      },
      {
        "slug": "mt-nd1",
        "symbol": "MT-ND1",
        "hgnc": "HGNC:7455",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd1"
      },
      {
        "slug": "mt-nd4",
        "symbol": "MT-ND4",
        "hgnc": "HGNC:7459",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd4"
      },
      {
        "slug": "mt-nd5",
        "symbol": "MT-ND5",
        "hgnc": "HGNC:7461",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd5"
      },
      {
        "slug": "mt-nd6",
        "symbol": "MT-ND6",
        "hgnc": "HGNC:7462",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd6"
      },
      {
        "slug": "mt-tf",
        "symbol": "MT-TF",
        "hgnc": "HGNC:7481",
        "name": "mitochondrially encoded tRNA-Phe (UUU/C)",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tf"
      },
      {
        "slug": "mt-th",
        "symbol": "MT-TH",
        "hgnc": "HGNC:7487",
        "name": "mitochondrially encoded tRNA-His (CAU/C)",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-th"
      },
      {
        "slug": "mt-tl1",
        "symbol": "MT-TL1",
        "hgnc": "HGNC:7490",
        "name": "mitochondrially encoded tRNA-Leu (UUA/G) 1",
        "frequency": "very-frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/mt-tl1"
      },
      {
        "slug": "mt-tq",
        "symbol": "MT-TQ",
        "hgnc": "HGNC:7495",
        "name": "mitochondrially encoded tRNA-Gln (CAA/G)",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tq"
      },
      {
        "slug": "mt-ts1",
        "symbol": "MT-TS1",
        "hgnc": "HGNC:7497",
        "name": "mitochondrially encoded tRNA-Ser (UCN) 1",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/mt-ts1"
      },
      {
        "slug": "mt-ts2",
        "symbol": "MT-TS2",
        "hgnc": "HGNC:7498",
        "name": "mitochondrially encoded tRNA-Ser (AGU/C) 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-ts2"
      },
      {
        "slug": "mt-tw",
        "symbol": "MT-TW",
        "hgnc": "HGNC:7501",
        "name": "mitochondrially encoded tRNA-Trp (UGA/G)",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tw"
      },
      {
        "slug": "pdhx",
        "symbol": "PDHX",
        "hgnc": "HGNC:21350",
        "name": "pyruvate dehydrogenase complex component X",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdhx"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "serac1",
        "symbol": "SERAC1",
        "hgnc": "HGNC:21061",
        "name": "serine active site containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serac1"
      },
      {
        "slug": "slc25a3",
        "symbol": "SLC25A3",
        "hgnc": "HGNC:10989",
        "name": "solute carrier family 25 member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a3"
      },
      {
        "slug": "sucla2",
        "symbol": "SUCLA2",
        "hgnc": "HGNC:11448",
        "name": "succinate-CoA ligase ADP-forming subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sucla2"
      },
      {
        "slug": "tango2",
        "symbol": "TANGO2",
        "hgnc": "HGNC:25439",
        "name": "transport and golgi organization 2 homolog",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tango2"
      },
      {
        "slug": "timm50",
        "symbol": "TIMM50",
        "hgnc": "HGNC:23656",
        "name": "translocase of inner mitochondrial membrane 50",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/timm50"
      },
      {
        "slug": "txn2",
        "symbol": "TXN2",
        "hgnc": "HGNC:17772",
        "name": "thioredoxin 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/txn2"
      },
      {
        "slug": "aars2",
        "symbol": "AARS2",
        "hgnc": "HGNC:21022",
        "name": "alanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars2"
      },
      {
        "slug": "acad9",
        "symbol": "ACAD9",
        "hgnc": "HGNC:21497",
        "name": "acyl-CoA dehydrogenase family member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acad9"
      },
      {
        "slug": "atp5f1a",
        "symbol": "ATP5F1A",
        "hgnc": "HGNC:823",
        "name": "ATP synthase F1 subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5f1a"
      },
      {
        "slug": "bola3",
        "symbol": "BOLA3",
        "hgnc": "HGNC:24415",
        "name": "bolA family member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bola3"
      },
      {
        "slug": "c1qbp",
        "symbol": "C1QBP",
        "hgnc": "HGNC:1243",
        "name": "complement C1q binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1qbp"
      },
      {
        "slug": "cars2",
        "symbol": "CARS2",
        "hgnc": "HGNC:25695",
        "name": "cysteinyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cars2"
      },
      {
        "slug": "chchd10",
        "symbol": "CHCHD10",
        "hgnc": "HGNC:15559",
        "name": "coiled-coil-helix-coiled-coil-helix domain containing 10",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chchd10"
      },
      {
        "slug": "clpb",
        "symbol": "CLPB",
        "hgnc": "HGNC:30664",
        "name": "ClpB family mitochondrial disaggregase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clpb"
      },
      {
        "slug": "coq8a",
        "symbol": "COQ8A",
        "hgnc": "HGNC:16812",
        "name": "coenzyme Q8A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/coq8a"
      },
      {
        "slug": "cox4i1",
        "symbol": "COX4I1",
        "hgnc": "HGNC:2265",
        "name": "cytochrome c oxidase subunit 4I1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox4i1"
      },
      {
        "slug": "dnajc19",
        "symbol": "DNAJC19",
        "hgnc": "HGNC:30528",
        "name": "DnaJ heat shock protein family (Hsp40) member C19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc19"
      },
      {
        "slug": "dnm1l",
        "symbol": "DNM1L",
        "hgnc": "HGNC:2973",
        "name": "dynamin 1L",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dnm1l"
      },
      {
        "slug": "fastkd2",
        "symbol": "FASTKD2",
        "hgnc": "HGNC:29160",
        "name": "FASTK mitochondrial RNA regulator 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fastkd2"
      },
      {
        "slug": "glrx5",
        "symbol": "GLRX5",
        "hgnc": "HGNC:20134",
        "name": "glutaredoxin 5",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/glrx5"
      },
      {
        "slug": "hibch",
        "symbol": "HIBCH",
        "hgnc": "HGNC:4908",
        "name": "3-hydroxyisobutyryl-CoA hydrolase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hibch"
      },
      {
        "slug": "hmgcl",
        "symbol": "HMGCL",
        "hgnc": "HGNC:5005",
        "name": "3-hydroxy-3-methylglutaryl-CoA lyase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hmgcl"
      },
      {
        "slug": "hpdl",
        "symbol": "HPDL",
        "hgnc": "HGNC:28242",
        "name": "4-hydroxyphenylpyruvate dioxygenase like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpdl"
      },
      {
        "slug": "hspd1",
        "symbol": "HSPD1",
        "hgnc": "HGNC:5261",
        "name": "heat shock protein family D (Hsp60) member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspd1"
      },
      {
        "slug": "iba57",
        "symbol": "IBA57",
        "hgnc": "HGNC:27302",
        "name": "iron-sulfur cluster assembly factor IBA57",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iba57"
      },
      {
        "slug": "isca1",
        "symbol": "ISCA1",
        "hgnc": "HGNC:28660",
        "name": "iron-sulfur cluster assembly 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/isca1"
      },
      {
        "slug": "klc4",
        "symbol": "KLC4",
        "hgnc": "HGNC:21624",
        "name": "kinesin light chain 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klc4"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldb3"
      },
      {
        "slug": "letm1",
        "symbol": "LETM1",
        "hgnc": "HGNC:6556",
        "name": "leucine zipper and EF-hand containing transmembrane protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/letm1"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "mrpl39",
        "symbol": "MRPL39",
        "hgnc": "HGNC:14027",
        "name": "mitochondrial ribosomal protein L39",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrpl39"
      },
      {
        "slug": "mrpl44",
        "symbol": "MRPL44",
        "hgnc": "HGNC:16650",
        "name": "mitochondrial ribosomal protein L44",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrpl44"
      },
      {
        "slug": "mt-atp6",
        "symbol": "MT-ATP6",
        "hgnc": "HGNC:7414",
        "name": "mitochondrially encoded ATP synthase membrane subunit 6",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-atp6"
      },
      {
        "slug": "mt-nd2",
        "symbol": "MT-ND2",
        "hgnc": "HGNC:7456",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd2"
      },
      {
        "slug": "mt-nd3",
        "symbol": "MT-ND3",
        "hgnc": "HGNC:7458",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd3"
      },
      {
        "slug": "mt-tk",
        "symbol": "MT-TK",
        "hgnc": "HGNC:7489",
        "name": "mitochondrially encoded tRNA-Lys (AAA/G)",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mt-tk"
      },
      {
        "slug": "mt-tl2",
        "symbol": "MT-TL2",
        "hgnc": "HGNC:7491",
        "name": "mitochondrially encoded tRNA-Leu (CUN) 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tl2"
      },
      {
        "slug": "mt-tn",
        "symbol": "MT-TN",
        "hgnc": "HGNC:7493",
        "name": "mitochondrially encoded tRNA-Asn (AAU/C)",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tn"
      },
      {
        "slug": "mt-tv",
        "symbol": "MT-TV",
        "hgnc": "HGNC:7500",
        "name": "mitochondrially encoded tRNA-Val (GUN)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tv"
      },
      {
        "slug": "mtfmt",
        "symbol": "MTFMT",
        "hgnc": "HGNC:29666",
        "name": "mitochondrial methionyl-tRNA formyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtfmt"
      },
      {
        "slug": "naxd",
        "symbol": "NAXD",
        "hgnc": "HGNC:25576",
        "name": "NAD(P)HX dehydratase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/naxd"
      },
      {
        "slug": "ndufa1",
        "symbol": "NDUFA1",
        "hgnc": "HGNC:7683",
        "name": "NADH:ubiquinone oxidoreductase subunit A1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa1"
      },
      {
        "slug": "ndufs2",
        "symbol": "NDUFS2",
        "hgnc": "HGNC:7708",
        "name": "NADH:ubiquinone oxidoreductase core subunit S2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs2"
      },
      {
        "slug": "ndufv1",
        "symbol": "NDUFV1",
        "hgnc": "HGNC:7716",
        "name": "NADH:ubiquinone oxidoreductase core subunit V1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufv1"
      },
      {
        "slug": "ngly1",
        "symbol": "NGLY1",
        "hgnc": "HGNC:17646",
        "name": "N-glycanase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngly1"
      },
      {
        "slug": "pck1",
        "symbol": "PCK1",
        "hgnc": "HGNC:8724",
        "name": "phosphoenolpyruvate carboxykinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck1"
      },
      {
        "slug": "pck2",
        "symbol": "PCK2",
        "hgnc": "HGNC:8725",
        "name": "phosphoenolpyruvate carboxykinase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck2"
      },
      {
        "slug": "pdp1",
        "symbol": "PDP1",
        "hgnc": "HGNC:9279",
        "name": "pyruvate dehydrogenase phosphatase catalytic subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdp1"
      },
      {
        "slug": "phkg2",
        "symbol": "PHKG2",
        "hgnc": "HGNC:8931",
        "name": "phosphorylase kinase catalytic subunit gamma 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phkg2"
      },
      {
        "slug": "plpbp",
        "symbol": "PLPBP",
        "hgnc": "HGNC:9457",
        "name": "pyridoxal phosphate binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plpbp"
      },
      {
        "slug": "pmpcb",
        "symbol": "PMPCB",
        "hgnc": "HGNC:9119",
        "name": "peptidase, mitochondrial processing subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmpcb"
      },
      {
        "slug": "pnpo",
        "symbol": "PNPO",
        "hgnc": "HGNC:30260",
        "name": "pyridoxamine 5'-phosphate oxidase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pnpo"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "ppcs",
        "symbol": "PPCS",
        "hgnc": "HGNC:25686",
        "name": "phosphopantothenoylcysteine synthetase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppcs"
      },
      {
        "slug": "ptpmt1",
        "symbol": "PTPMT1",
        "hgnc": "HGNC:26965",
        "name": "protein tyrosine phosphatase mitochondrial 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpmt1"
      },
      {
        "slug": "pus1",
        "symbol": "PUS1",
        "hgnc": "HGNC:15508",
        "name": "pseudouridine synthase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pus1"
      },
      {
        "slug": "rars2",
        "symbol": "RARS2",
        "hgnc": "HGNC:21406",
        "name": "arginyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rars2"
      },
      {
        "slug": "rnaseh1",
        "symbol": "RNASEH1",
        "hgnc": "HGNC:18466",
        "name": "ribonuclease H1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh1"
      },
      {
        "slug": "stat2",
        "symbol": "STAT2",
        "hgnc": "HGNC:11363",
        "name": "signal transducer and activator of transcription 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat2"
      },
      {
        "slug": "suclg1",
        "symbol": "SUCLG1",
        "hgnc": "HGNC:11449",
        "name": "succinate-CoA ligase GDP/ADP-forming subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/suclg1"
      },
      {
        "slug": "tk2",
        "symbol": "TK2",
        "hgnc": "HGNC:11831",
        "name": "thymidine kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tk2"
      },
      {
        "slug": "tpk1",
        "symbol": "TPK1",
        "hgnc": "HGNC:17358",
        "name": "thiamin pyrophosphokinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpk1"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "wars2",
        "symbol": "WARS2",
        "hgnc": "HGNC:12730",
        "name": "tryptophanyl tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wars2"
      },
      {
        "slug": "yme1l1",
        "symbol": "YME1L1",
        "hgnc": "HGNC:12843",
        "name": "YME1 like 1 ATPase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yme1l1"
      },
      {
        "slug": "acat1",
        "symbol": "ACAT1",
        "hgnc": "HGNC:93",
        "name": "acetyl-CoA acetyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acat1"
      },
      {
        "slug": "cyp27a1",
        "symbol": "CYP27A1",
        "hgnc": "HGNC:2605",
        "name": "cytochrome P450 family 27 subfamily A member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp27a1"
      },
      {
        "slug": "dars2",
        "symbol": "DARS2",
        "hgnc": "HGNC:25538",
        "name": "aspartyl-tRNA synthetase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dars2"
      },
      {
        "slug": "dguok",
        "symbol": "DGUOK",
        "hgnc": "HGNC:2858",
        "name": "deoxyguanosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dguok"
      },
      {
        "slug": "gfm2",
        "symbol": "GFM2",
        "hgnc": "HGNC:29682",
        "name": "GTP dependent ribosome recycling factor mitochondrial 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gfm2"
      },
      {
        "slug": "ift56",
        "symbol": "IFT56",
        "hgnc": "HGNC:21882",
        "name": "intraflagellar transport 56",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift56"
      },
      {
        "slug": "isca2",
        "symbol": "ISCA2",
        "hgnc": "HGNC:19857",
        "name": "iron-sulfur cluster assembly 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/isca2"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "ndufa6",
        "symbol": "NDUFA6",
        "hgnc": "HGNC:7690",
        "name": "NADH:ubiquinone oxidoreductase subunit A6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa6"
      },
      {
        "slug": "ocrl",
        "symbol": "OCRL",
        "hgnc": "HGNC:8108",
        "name": "OCRL inositol polyphosphate-5-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ocrl"
      },
      {
        "slug": "pitrm1",
        "symbol": "PITRM1",
        "hgnc": "HGNC:17663",
        "name": "pitrilysin metallopeptidase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pitrm1"
      },
      {
        "slug": "polrmt",
        "symbol": "POLRMT",
        "hgnc": "HGNC:9200",
        "name": "RNA polymerase mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polrmt"
      },
      {
        "slug": "prorp",
        "symbol": "PRORP",
        "hgnc": "HGNC:19958",
        "name": "protein only RNase P catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prorp"
      },
      {
        "slug": "rars1",
        "symbol": "RARS1",
        "hgnc": "HGNC:9870",
        "name": "arginyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rars1"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "upb1",
        "symbol": "UPB1",
        "hgnc": "HGNC:16297",
        "name": "beta-ureidopropionase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/upb1"
      },
      {
        "slug": "acat2",
        "symbol": "ACAT2",
        "hgnc": "HGNC:94",
        "name": "acetyl-CoA acetyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acat2"
      },
      {
        "slug": "adamts13",
        "symbol": "ADAMTS13",
        "hgnc": "HGNC:1366",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts13"
      },
      {
        "slug": "agk",
        "symbol": "AGK",
        "hgnc": "HGNC:21869",
        "name": "acylglycerol kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agk"
      },
      {
        "slug": "ampd1",
        "symbol": "AMPD1",
        "hgnc": "HGNC:468",
        "name": "adenosine monophosphate deaminase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ampd1"
      },
      {
        "slug": "ampd3",
        "symbol": "AMPD3",
        "hgnc": "HGNC:470",
        "name": "adenosine monophosphate deaminase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ampd3"
      },
      {
        "slug": "bcs1l",
        "symbol": "BCS1L",
        "hgnc": "HGNC:1020",
        "name": "BCS1 ubiquinol-cytochrome c reductase complex chaperone",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcs1l"
      },
      {
        "slug": "coq9",
        "symbol": "COQ9",
        "hgnc": "HGNC:25302",
        "name": "coenzyme Q9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq9"
      },
      {
        "slug": "cox15",
        "symbol": "COX15",
        "hgnc": "HGNC:2263",
        "name": "cytochrome c oxidase assembly factor COX15",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox15"
      },
      {
        "slug": "ears2",
        "symbol": "EARS2",
        "hgnc": "HGNC:29419",
        "name": "glutamyl-tRNA synthetase 2, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ears2"
      },
      {
        "slug": "gfm1",
        "symbol": "GFM1",
        "hgnc": "HGNC:13780",
        "name": "G elongation factor mitochondrial 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfm1"
      },
      {
        "slug": "gys2",
        "symbol": "GYS2",
        "hgnc": "HGNC:4707",
        "name": "glycogen synthase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gys2"
      },
      {
        "slug": "htra2",
        "symbol": "HTRA2",
        "hgnc": "HGNC:14348",
        "name": "HtrA serine peptidase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htra2"
      },
      {
        "slug": "iscu",
        "symbol": "ISCU",
        "hgnc": "HGNC:29882",
        "name": "iron-sulfur cluster assembly enzyme",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iscu"
      },
      {
        "slug": "ldha",
        "symbol": "LDHA",
        "hgnc": "HGNC:6535",
        "name": "lactate dehydrogenase A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldha"
      },
      {
        "slug": "mpc1",
        "symbol": "MPC1",
        "hgnc": "HGNC:21606",
        "name": "mitochondrial pyruvate carrier 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpc1"
      },
      {
        "slug": "mrps22",
        "symbol": "MRPS22",
        "hgnc": "HGNC:14508",
        "name": "mitochondrial ribosomal protein S22",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps22"
      },
      {
        "slug": "mt-ti",
        "symbol": "MT-TI",
        "hgnc": "HGNC:7488",
        "name": "mitochondrially encoded tRNA-Ile (AUU/C)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-ti"
      },
      {
        "slug": "mt-tp",
        "symbol": "MT-TP",
        "hgnc": "HGNC:7494",
        "name": "mitochondrially encoded tRNA-Pro (CCN)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tp"
      },
      {
        "slug": "nars2",
        "symbol": "NARS2",
        "hgnc": "HGNC:26274",
        "name": "asparaginyl-tRNA synthetase 2, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nars2"
      },
      {
        "slug": "ndufaf1",
        "symbol": "NDUFAF1",
        "hgnc": "HGNC:18828",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf1"
      },
      {
        "slug": "ndufs3",
        "symbol": "NDUFS3",
        "hgnc": "HGNC:7710",
        "name": "NADH:ubiquinone oxidoreductase core subunit S3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs3"
      },
      {
        "slug": "pc",
        "symbol": "PC",
        "hgnc": "HGNC:8636",
        "name": "pyruvate carboxylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pc"
      },
      {
        "slug": "slc25a26",
        "symbol": "SLC25A26",
        "hgnc": "HGNC:20661",
        "name": "solute carrier family 25 member 26",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a26"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "surf1",
        "symbol": "SURF1",
        "hgnc": "HGNC:11474",
        "name": "SURF1 cytochrome c oxidase assembly factor",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/surf1"
      },
      {
        "slug": "synj1",
        "symbol": "SYNJ1",
        "hgnc": "HGNC:11503",
        "name": "synaptojanin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/synj1"
      },
      {
        "slug": "taco1",
        "symbol": "TACO1",
        "hgnc": "HGNC:24316",
        "name": "translational activator of cytochrome c oxidase I",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taco1"
      },
      {
        "slug": "tmem70",
        "symbol": "TMEM70",
        "hgnc": "HGNC:26050",
        "name": "transmembrane protein 70",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem70"
      },
      {
        "slug": "tufm",
        "symbol": "TUFM",
        "hgnc": "HGNC:12420",
        "name": "Tu translation elongation factor, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tufm"
      }
    ]
  }
}