{
  "url": "https://dantelabs.com/traits/hypomimic-face",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypomimic-face",
    "id": "HP:0000338",
    "name": "Decreased facial expressions",
    "label": "Hypomimic face",
    "definition": "A reduced degree of motion of the muscles beneath the skin of the face, often associated with reduced facial crease formation.",
    "synonyms": [
      "Decreased facial muscle movement",
      "Dull facial expression",
      "Hypomimia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-facial-musculature",
        "name": "Abnormality of facial muscles",
        "url": "https://dantelabs.com/traits/abnormality-of-facial-musculature"
      },
      {
        "slug": "decreased-facial-expression",
        "name": "Decreased facial expression",
        "url": "https://dantelabs.com/traits/decreased-facial-expression"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atcay",
        "symbol": "ATCAY",
        "hgnc": "HGNC:779",
        "name": "ATCAY kinesin light chain interacting caytaxin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atcay"
      },
      {
        "slug": "dnajc6",
        "symbol": "DNAJC6",
        "hgnc": "HGNC:15469",
        "name": "DnaJ heat shock protein family (Hsp40) member C6",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dnajc6"
      },
      {
        "slug": "mymx",
        "symbol": "MYMX",
        "hgnc": "HGNC:52391",
        "name": "myomixer, myoblast fusion factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mymx"
      },
      {
        "slug": "ppfia3",
        "symbol": "PPFIA3",
        "hgnc": "HGNC:9247",
        "name": "PPFI scaffold protein A3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppfia3"
      },
      {
        "slug": "rnu2-2",
        "symbol": "RNU2-2",
        "hgnc": "HGNC:10152",
        "name": "RNA, U2 small nuclear 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu2-2"
      },
      {
        "slug": "slc18a2",
        "symbol": "SLC18A2",
        "hgnc": "HGNC:10935",
        "name": "solute carrier family 18 member A2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc18a2"
      },
      {
        "slug": "slc6a3",
        "symbol": "SLC6A3",
        "hgnc": "HGNC:11049",
        "name": "solute carrier family 6 member 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc6a3"
      },
      {
        "slug": "tecpr2",
        "symbol": "TECPR2",
        "hgnc": "HGNC:19957",
        "name": "tectonin beta-propeller repeat containing 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tecpr2"
      },
      {
        "slug": "atp6ap2",
        "symbol": "ATP6AP2",
        "hgnc": "HGNC:18305",
        "name": "ATPase H+ transporting accessory protein 2",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/atp6ap2"
      },
      {
        "slug": "podxl",
        "symbol": "PODXL",
        "hgnc": "HGNC:9171",
        "name": "podocalyxin like",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/podxl"
      },
      {
        "slug": "synj1",
        "symbol": "SYNJ1",
        "hgnc": "HGNC:11503",
        "name": "synaptojanin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/synj1"
      },
      {
        "slug": "atp13a2",
        "symbol": "ATP13A2",
        "hgnc": "HGNC:30213",
        "name": "ATPase cation transporting 13A2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp13a2"
      },
      {
        "slug": "atp1a3",
        "symbol": "ATP1A3",
        "hgnc": "HGNC:801",
        "name": "ATPase Na+/K+ transporting subunit alpha 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp1a3"
      },
      {
        "slug": "cntnap1",
        "symbol": "CNTNAP1",
        "hgnc": "HGNC:8011",
        "name": "contactin associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cntnap1"
      },
      {
        "slug": "fbxo7",
        "symbol": "FBXO7",
        "hgnc": "HGNC:13586",
        "name": "F-box protein 7",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fbxo7"
      },
      {
        "slug": "ftl",
        "symbol": "FTL",
        "hgnc": "HGNC:3999",
        "name": "ferritin light chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ftl"
      },
      {
        "slug": "kcnk9",
        "symbol": "KCNK9",
        "hgnc": "HGNC:6283",
        "name": "potassium two pore domain channel subfamily K member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnk9"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "polg2",
        "symbol": "POLG2",
        "hgnc": "HGNC:9180",
        "name": "DNA polymerase gamma 2, accessory subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg2"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "slc30a10",
        "symbol": "SLC30A10",
        "hgnc": "HGNC:25355",
        "name": "solute carrier family 30 member 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc30a10"
      },
      {
        "slug": "slc39a14",
        "symbol": "SLC39A14",
        "hgnc": "HGNC:20858",
        "name": "solute carrier family 39 member 14",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc39a14"
      },
      {
        "slug": "snca",
        "symbol": "SNCA",
        "hgnc": "HGNC:11138",
        "name": "synuclein alpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/snca"
      },
      {
        "slug": "spr",
        "symbol": "SPR",
        "hgnc": "HGNC:11257",
        "name": "sepiapterin reductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spr"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "wars2",
        "symbol": "WARS2",
        "hgnc": "HGNC:12730",
        "name": "tryptophanyl tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wars2"
      },
      {
        "slug": "cltc",
        "symbol": "CLTC",
        "hgnc": "HGNC:2092",
        "name": "clathrin heavy chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cltc"
      },
      {
        "slug": "ddhd2",
        "symbol": "DDHD2",
        "hgnc": "HGNC:29106",
        "name": "DDHD domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddhd2"
      },
      {
        "slug": "dnajc13",
        "symbol": "DNAJC13",
        "hgnc": "HGNC:30343",
        "name": "DnaJ heat shock protein family (Hsp40) member C13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc13"
      },
      {
        "slug": "eif4g1",
        "symbol": "EIF4G1",
        "hgnc": "HGNC:3296",
        "name": "eukaryotic translation initiation factor 4 gamma 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif4g1"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "gigyf2",
        "symbol": "GIGYF2",
        "hgnc": "HGNC:11960",
        "name": "GRB10 interacting GYF protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gigyf2"
      },
      {
        "slug": "jam2",
        "symbol": "JAM2",
        "hgnc": "HGNC:14686",
        "name": "junctional adhesion molecule 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jam2"
      },
      {
        "slug": "lrrk2",
        "symbol": "LRRK2",
        "hgnc": "HGNC:18618",
        "name": "leucine rich repeat kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrk2"
      },
      {
        "slug": "prdx3",
        "symbol": "PRDX3",
        "hgnc": "HGNC:9354",
        "name": "peroxiredoxin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdx3"
      },
      {
        "slug": "vps35",
        "symbol": "VPS35",
        "hgnc": "HGNC:13487",
        "name": "VPS35 retromer complex component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps35"
      },
      {
        "slug": "cc2d1a",
        "symbol": "CC2D1A",
        "hgnc": "HGNC:30237",
        "name": "coiled-coil and C2 domain containing 1A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cc2d1a"
      },
      {
        "slug": "plaa",
        "symbol": "PLAA",
        "hgnc": "HGNC:9043",
        "name": "phospholipase A2 activating protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plaa"
      },
      {
        "slug": "txnl4a",
        "symbol": "TXNL4A",
        "hgnc": "HGNC:30551",
        "name": "thioredoxin like 4A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/txnl4a"
      }
    ]
  }
}