{
  "url": "https://dantelabs.com/traits/hyperinsulinemic-hypoglycemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hyperinsulinemic-hypoglycemia",
    "id": "HP:0000825",
    "name": "Hyperinsulinemic hypoglycemia",
    "definition": "An increased concentration of insulin combined with a decreased concentration of glucose in the blood.",
    "synonyms": [
      "Hyperinsulinaemic hypoglycaemia",
      "Hyperinsulinemia hypoglycemia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "hyperinsulinemia",
        "name": "Hyperinsulinemia",
        "url": "https://dantelabs.com/traits/hyperinsulinemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "hgnc": "HGNC:59",
        "name": "ATP binding cassette subfamily C member 8",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/abcc8"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "hgnc": "HGNC:4195",
        "name": "glucokinase",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gck"
      },
      {
        "slug": "glud1",
        "symbol": "GLUD1",
        "hgnc": "HGNC:4335",
        "name": "glutamate dehydrogenase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/glud1"
      },
      {
        "slug": "hadh",
        "symbol": "HADH",
        "hgnc": "HGNC:4799",
        "name": "hydroxyacyl-CoA dehydrogenase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hadh"
      },
      {
        "slug": "insr",
        "symbol": "INSR",
        "hgnc": "HGNC:6091",
        "name": "insulin receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/insr"
      },
      {
        "slug": "kcnj11",
        "symbol": "KCNJ11",
        "hgnc": "HGNC:6257",
        "name": "potassium inwardly rectifying channel subfamily J member 11",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/kcnj11"
      },
      {
        "slug": "trmt10a",
        "symbol": "TRMT10A",
        "hgnc": "HGNC:28403",
        "name": "tRNA methyltransferase 10A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt10a"
      },
      {
        "slug": "hnf1a",
        "symbol": "HNF1A",
        "hgnc": "HGNC:11621",
        "name": "HNF1 homeobox A",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnf1a"
      },
      {
        "slug": "hnf4a",
        "symbol": "HNF4A",
        "hgnc": "HGNC:5024",
        "name": "hepatocyte nuclear factor 4 alpha",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnf4a"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "ucp2",
        "symbol": "UCP2",
        "hgnc": "HGNC:12518",
        "name": "uncoupling protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ucp2"
      },
      {
        "slug": "yy1",
        "symbol": "YY1",
        "hgnc": "HGNC:12856",
        "name": "YY1 transcription factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yy1"
      },
      {
        "slug": "cdkn1b",
        "symbol": "CDKN1B",
        "hgnc": "HGNC:1785",
        "name": "cyclin dependent kinase inhibitor 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1b"
      },
      {
        "slug": "focad",
        "symbol": "FOCAD",
        "hgnc": "HGNC:23377",
        "name": "focadhesin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/focad"
      },
      {
        "slug": "mpi",
        "symbol": "MPI",
        "hgnc": "HGNC:7216",
        "name": "mannose phosphate isomerase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mpi"
      },
      {
        "slug": "appl1",
        "symbol": "APPL1",
        "hgnc": "HGNC:24035",
        "name": "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/appl1"
      },
      {
        "slug": "blk",
        "symbol": "BLK",
        "hgnc": "HGNC:1057",
        "name": "BLK proto-oncogene, Src family tyrosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blk"
      },
      {
        "slug": "cel",
        "symbol": "CEL",
        "hgnc": "HGNC:1848",
        "name": "carboxyl ester lipase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cel"
      },
      {
        "slug": "ins",
        "symbol": "INS",
        "hgnc": "HGNC:6081",
        "name": "insulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ins"
      },
      {
        "slug": "klf11",
        "symbol": "KLF11",
        "hgnc": "HGNC:11811",
        "name": "KLF transcription factor 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf11"
      },
      {
        "slug": "neurod1",
        "symbol": "NEUROD1",
        "hgnc": "HGNC:7762",
        "name": "neuronal differentiation 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neurod1"
      },
      {
        "slug": "pax4",
        "symbol": "PAX4",
        "hgnc": "HGNC:8618",
        "name": "paired box 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax4"
      },
      {
        "slug": "pdx1",
        "symbol": "PDX1",
        "hgnc": "HGNC:6107",
        "name": "pancreatic and duodenal homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdx1"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "mafa",
        "symbol": "MAFA",
        "hgnc": "HGNC:23145",
        "name": "MAF bZIP transcription factor A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mafa"
      },
      {
        "slug": "slc16a1",
        "symbol": "SLC16A1",
        "hgnc": "HGNC:10922",
        "name": "solute carrier family 16 member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc16a1"
      }
    ]
  }
}