{
  "url": "https://dantelabs.com/traits/hyperbilirubinemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hyperbilirubinemia",
    "id": "HP:0002904",
    "name": "High blood bilirubin levels",
    "label": "Hyperbilirubinemia",
    "definition": "An increased amount of bilirubin in the blood.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-bilirubin-concentration",
        "name": "Abnormal circulating bilirubin concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-bilirubin-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "conjugated-hyperbilirubinemia",
        "name": "Conjugated hyperbilirubinemia",
        "genes": 43,
        "url": "https://dantelabs.com/traits/conjugated-hyperbilirubinemia"
      },
      {
        "slug": "neonatal-hyperbilirubinemia",
        "name": "Neonatal hyperbilirubinemia",
        "genes": 25,
        "url": "https://dantelabs.com/traits/neonatal-hyperbilirubinemia"
      },
      {
        "slug": "unconjugated-hyperbilirubinemia",
        "name": "Unconjugated hyperbilirubinemia",
        "genes": 22,
        "url": "https://dantelabs.com/traits/unconjugated-hyperbilirubinemia"
      },
      {
        "slug": "increased-total-bilirubin",
        "name": "High bili total",
        "genes": 17,
        "url": "https://dantelabs.com/traits/increased-total-bilirubin"
      },
      {
        "slug": "neonatal-unconjugated-hyperbilirubinemia",
        "name": "Neonatal unconjugated hyperbilirubinemia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/neonatal-unconjugated-hyperbilirubinemia"
      }
    ],
    "genes": [
      {
        "slug": "abcd3",
        "symbol": "ABCD3",
        "hgnc": "HGNC:67",
        "name": "ATP binding cassette subfamily D member 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd3"
      },
      {
        "slug": "adk",
        "symbol": "ADK",
        "hgnc": "HGNC:257",
        "name": "adenosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adk"
      },
      {
        "slug": "aldoa",
        "symbol": "ALDOA",
        "hgnc": "HGNC:414",
        "name": "aldolase, fructose-bisphosphate A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldoa"
      },
      {
        "slug": "amacr",
        "symbol": "AMACR",
        "hgnc": "HGNC:451",
        "name": "alpha-methylacyl-CoA racemase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amacr"
      },
      {
        "slug": "ank1",
        "symbol": "ANK1",
        "hgnc": "HGNC:492",
        "name": "ankyrin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ank1"
      },
      {
        "slug": "atp7b",
        "symbol": "ATP7B",
        "hgnc": "HGNC:870",
        "name": "ATPase copper transporting beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7b"
      },
      {
        "slug": "cdan1",
        "symbol": "CDAN1",
        "hgnc": "HGNC:1713",
        "name": "codanin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdan1"
      },
      {
        "slug": "chaserr",
        "symbol": "CHASERR",
        "hgnc": "HGNC:48626",
        "name": "CHD2 adjacent suppressive regulatory RNA",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chaserr"
      },
      {
        "slug": "cyp7b1",
        "symbol": "CYP7B1",
        "hgnc": "HGNC:2652",
        "name": "cytochrome P450 family 7 subfamily B member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp7b1"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "gli2",
        "symbol": "GLI2",
        "hgnc": "HGNC:4318",
        "name": "GLI family zinc finger 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gli2"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "nt5c3a",
        "symbol": "NT5C3A",
        "hgnc": "HGNC:17820",
        "name": "5'-nucleotidase, cytosolic IIIA",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nt5c3a"
      },
      {
        "slug": "odc1",
        "symbol": "ODC1",
        "hgnc": "HGNC:8109",
        "name": "ornithine decarboxylase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odc1"
      },
      {
        "slug": "pex1",
        "symbol": "PEX1",
        "hgnc": "HGNC:8850",
        "name": "peroxisomal biogenesis factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex1"
      },
      {
        "slug": "pex19",
        "symbol": "PEX19",
        "hgnc": "HGNC:9713",
        "name": "peroxisomal biogenesis factor 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex19"
      },
      {
        "slug": "rnu6atac",
        "symbol": "RNU6ATAC",
        "hgnc": "HGNC:34017",
        "name": "RNA, U6atac small nuclear",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu6atac"
      },
      {
        "slug": "sc5d",
        "symbol": "SC5D",
        "hgnc": "HGNC:10547",
        "name": "sterol-C5-desaturase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sc5d"
      },
      {
        "slug": "slc19a1",
        "symbol": "SLC19A1",
        "hgnc": "HGNC:10937",
        "name": "solute carrier family 19 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc19a1"
      },
      {
        "slug": "slc25a13",
        "symbol": "SLC25A13",
        "hgnc": "HGNC:10983",
        "name": "solute carrier family 25 member 13",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc25a13"
      },
      {
        "slug": "sptb",
        "symbol": "SPTB",
        "hgnc": "HGNC:11274",
        "name": "spectrin beta, erythrocytic",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/sptb"
      },
      {
        "slug": "tmem63b",
        "symbol": "TMEM63B",
        "hgnc": "HGNC:17735",
        "name": "transmembrane protein 63B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem63b"
      },
      {
        "slug": "vps33b",
        "symbol": "VPS33B",
        "hgnc": "HGNC:12712",
        "name": "VPS33B late endosome and lysosome associated",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps33b"
      },
      {
        "slug": "vps50",
        "symbol": "VPS50",
        "hgnc": "HGNC:25956",
        "name": "VPS50 subunit of EARP/GARPII complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps50"
      },
      {
        "slug": "akr1d1",
        "symbol": "AKR1D1",
        "hgnc": "HGNC:388",
        "name": "aldo-keto reductase family 1 member D1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/akr1d1"
      },
      {
        "slug": "trmu",
        "symbol": "TRMU",
        "hgnc": "HGNC:25481",
        "name": "tRNA mitochondrial 2-thiouridylase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmu"
      },
      {
        "slug": "chd8",
        "symbol": "CHD8",
        "hgnc": "HGNC:20153",
        "name": "chromodomain helicase DNA binding protein 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd8"
      },
      {
        "slug": "epb42",
        "symbol": "EPB42",
        "hgnc": "HGNC:3381",
        "name": "erythrocyte membrane protein band 4.2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epb42"
      },
      {
        "slug": "focad",
        "symbol": "FOCAD",
        "hgnc": "HGNC:23377",
        "name": "focadhesin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/focad"
      },
      {
        "slug": "hmbs",
        "symbol": "HMBS",
        "hgnc": "HGNC:4982",
        "name": "hydroxymethylbilane synthase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmbs"
      },
      {
        "slug": "kif23",
        "symbol": "KIF23",
        "hgnc": "HGNC:6392",
        "name": "kinesin family member 23",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif23"
      },
      {
        "slug": "klf1",
        "symbol": "KLF1",
        "hgnc": "HGNC:6345",
        "name": "KLF transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf1"
      },
      {
        "slug": "mttp",
        "symbol": "MTTP",
        "hgnc": "HGNC:7467",
        "name": "microsomal triglyceride transfer protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mttp"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "nphp3",
        "symbol": "NPHP3",
        "hgnc": "HGNC:7907",
        "name": "nephrocystin 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphp3"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "pgk1",
        "symbol": "PGK1",
        "hgnc": "HGNC:8896",
        "name": "phosphoglycerate kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgk1"
      },
      {
        "slug": "racgap1",
        "symbol": "RACGAP1",
        "hgnc": "HGNC:9804",
        "name": "Rac GTPase activating protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/racgap1"
      },
      {
        "slug": "rhag",
        "symbol": "RHAG",
        "hgnc": "HGNC:10006",
        "name": "Rh associated glycoprotein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rhag"
      },
      {
        "slug": "rhce",
        "symbol": "RHCE",
        "hgnc": "HGNC:10008",
        "name": "Rh blood group CcEe antigens",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rhce"
      },
      {
        "slug": "rhd",
        "symbol": "RHD",
        "hgnc": "HGNC:10009",
        "name": "Rh blood group D antigen",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhd"
      },
      {
        "slug": "slc2a2",
        "symbol": "SLC2A2",
        "hgnc": "HGNC:11006",
        "name": "solute carrier family 2 member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a2"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "slco1b1",
        "symbol": "SLCO1B1",
        "hgnc": "HGNC:10959",
        "name": "solute carrier organic anion transporter family member 1B1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco1b1"
      },
      {
        "slug": "slco1b3",
        "symbol": "SLCO1B3",
        "hgnc": "HGNC:10961",
        "name": "solute carrier organic anion transporter family member 1B3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco1b3"
      },
      {
        "slug": "spta1",
        "symbol": "SPTA1",
        "hgnc": "HGNC:11272",
        "name": "spectrin alpha, erythrocytic 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spta1"
      },
      {
        "slug": "tfam",
        "symbol": "TFAM",
        "hgnc": "HGNC:11741",
        "name": "transcription factor A, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfam"
      },
      {
        "slug": "abcb11",
        "symbol": "ABCB11",
        "hgnc": "HGNC:42",
        "name": "ATP binding cassette subfamily B member 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb11"
      },
      {
        "slug": "abcb4",
        "symbol": "ABCB4",
        "hgnc": "HGNC:45",
        "name": "ATP binding cassette subfamily B member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb4"
      },
      {
        "slug": "atp8b1",
        "symbol": "ATP8B1",
        "hgnc": "HGNC:3706",
        "name": "ATPase phospholipid transporting 8B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp8b1"
      },
      {
        "slug": "eif2ak3",
        "symbol": "EIF2AK3",
        "hgnc": "HGNC:3255",
        "name": "eukaryotic translation initiation factor 2 alpha kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2ak3"
      },
      {
        "slug": "epb41",
        "symbol": "EPB41",
        "hgnc": "HGNC:3377",
        "name": "erythrocyte membrane protein band 4.1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epb41"
      },
      {
        "slug": "gypc",
        "symbol": "GYPC",
        "hgnc": "HGNC:4704",
        "name": "glycophorin C (Gerbich blood group)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gypc"
      },
      {
        "slug": "ift56",
        "symbol": "IFT56",
        "hgnc": "HGNC:21882",
        "name": "intraflagellar transport 56",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift56"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "naa10",
        "symbol": "NAA10",
        "hgnc": "HGNC:18704",
        "name": "N-alpha-acetyltransferase 10, NatA catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa10"
      },
      {
        "slug": "nr1h4",
        "symbol": "NR1H4",
        "hgnc": "HGNC:7967",
        "name": "nuclear receptor subfamily 1 group H member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr1h4"
      },
      {
        "slug": "rnu4atac",
        "symbol": "RNU4ATAC",
        "hgnc": "HGNC:34016",
        "name": "RNA, U4atac small nuclear",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4atac"
      },
      {
        "slug": "sptbn1",
        "symbol": "SPTBN1",
        "hgnc": "HGNC:11275",
        "name": "spectrin beta, non-erythrocytic 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptbn1"
      },
      {
        "slug": "tceal1",
        "symbol": "TCEAL1",
        "hgnc": "HGNC:11616",
        "name": "transcription elongation factor A like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tceal1"
      },
      {
        "slug": "znf699",
        "symbol": "ZNF699",
        "hgnc": "HGNC:24750",
        "name": "zinc finger protein 699",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf699"
      },
      {
        "slug": "aldob",
        "symbol": "ALDOB",
        "hgnc": "HGNC:417",
        "name": "aldolase, fructose-bisphosphate B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldob"
      },
      {
        "slug": "dguok",
        "symbol": "DGUOK",
        "hgnc": "HGNC:2858",
        "name": "deoxyguanosine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dguok"
      },
      {
        "slug": "fh",
        "symbol": "FH",
        "hgnc": "HGNC:3700",
        "name": "fumarate hydratase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fh"
      },
      {
        "slug": "gsr",
        "symbol": "GSR",
        "hgnc": "HGNC:4623",
        "name": "glutathione-disulfide reductase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gsr"
      },
      {
        "slug": "hk1",
        "symbol": "HK1",
        "hgnc": "HGNC:4922",
        "name": "hexokinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hk1"
      },
      {
        "slug": "kcnn4",
        "symbol": "KCNN4",
        "hgnc": "HGNC:6293",
        "name": "potassium calcium-activated channel subfamily N member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn4"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "ostm1",
        "symbol": "OSTM1",
        "hgnc": "HGNC:21652",
        "name": "osteoclastogenesis associated transmembrane protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ostm1"
      },
      {
        "slug": "pax8",
        "symbol": "PAX8",
        "hgnc": "HGNC:8622",
        "name": "paired box 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax8"
      },
      {
        "slug": "pomc",
        "symbol": "POMC",
        "hgnc": "HGNC:9201",
        "name": "proopiomelanocortin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomc"
      },
      {
        "slug": "rfx6",
        "symbol": "RFX6",
        "hgnc": "HGNC:21478",
        "name": "regulatory factor X6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx6"
      },
      {
        "slug": "wdr35",
        "symbol": "WDR35",
        "hgnc": "HGNC:29250",
        "name": "WD repeat domain 35",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr35"
      }
    ]
  }
}