{
  "url": "https://dantelabs.com/traits/highly-elevated-creatine-kinase",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "highly-elevated-creatine-kinase",
    "id": "HP:0030234",
    "name": "Highly elevated creatine kinase",
    "definition": "An increased CPK level between 4X and 50X above the upper normal level.",
    "synonyms": [
      "Highly elevated CPK",
      "Highly elevated creatine phosphokinase",
      "Highly elevated serum CK",
      "Highly elevated serum CPK",
      "Highly elevated serum phosph-CK"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "elevated-circulating-creatine-kinase-activity",
        "name": "Elevated blood creatine phosphokinase",
        "url": "https://dantelabs.com/traits/elevated-circulating-creatine-kinase-activity"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cd40lg",
        "symbol": "CD40LG",
        "hgnc": "HGNC:11935",
        "name": "CD40 ligand",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd40lg"
      },
      {
        "slug": "dpm3",
        "symbol": "DPM3",
        "hgnc": "HGNC:3007",
        "name": "dolichyl-phosphate mannosyltransferase subunit 3, regulatory",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpm3"
      },
      {
        "slug": "fdx2",
        "symbol": "FDX2",
        "hgnc": "HGNC:30546",
        "name": "ferredoxin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdx2"
      },
      {
        "slug": "lama2",
        "symbol": "LAMA2",
        "hgnc": "HGNC:6482",
        "name": "laminin subunit alpha 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama2"
      },
      {
        "slug": "lpin1",
        "symbol": "LPIN1",
        "hgnc": "HGNC:13345",
        "name": "lipin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lpin1"
      },
      {
        "slug": "mt-co1",
        "symbol": "MT-CO1",
        "hgnc": "HGNC:7419",
        "name": "mitochondrially encoded cytochrome c oxidase I",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co1"
      },
      {
        "slug": "mt-co3",
        "symbol": "MT-CO3",
        "hgnc": "HGNC:7422",
        "name": "mitochondrially encoded cytochrome c oxidase III",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co3"
      },
      {
        "slug": "obscn",
        "symbol": "OBSCN",
        "hgnc": "HGNC:15719",
        "name": "obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/obscn"
      },
      {
        "slug": "pygm",
        "symbol": "PYGM",
        "hgnc": "HGNC:9726",
        "name": "glycogen phosphorylase, muscle associated",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pygm"
      },
      {
        "slug": "snupn",
        "symbol": "SNUPN",
        "hgnc": "HGNC:14245",
        "name": "snurportin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snupn"
      },
      {
        "slug": "ano5",
        "symbol": "ANO5",
        "hgnc": "HGNC:27337",
        "name": "anoctamin 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano5"
      },
      {
        "slug": "crppa",
        "symbol": "CRPPA",
        "hgnc": "HGNC:37276",
        "name": "CDP-L-ribitol pyrophosphorylase A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crppa"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "popdc3",
        "symbol": "POPDC3",
        "hgnc": "HGNC:17649",
        "name": "popeye domain cAMP effector 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/popdc3"
      }
    ]
  }
}