{
  "url": "https://dantelabs.com/traits/heart-block",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "heart-block",
    "id": "HP:0012722",
    "name": "Heart block",
    "definition": "Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "cardiac-conduction-abnormality",
        "name": "Cardiac conduction abnormality",
        "url": "https://dantelabs.com/traits/cardiac-conduction-abnormality"
      }
    ],
    "narrower": [
      {
        "slug": "atrioventricular-block",
        "name": "Interruption of electrical communication between upper and lower chambers of heart",
        "genes": 41,
        "url": "https://dantelabs.com/traits/atrioventricular-block"
      },
      {
        "slug": "sick-sinus-syndrome",
        "name": "Sick sinus syndrome",
        "genes": 31,
        "url": "https://dantelabs.com/traits/sick-sinus-syndrome"
      },
      {
        "slug": "bundle-branch-block",
        "name": "Bundle branch block",
        "genes": 18,
        "url": "https://dantelabs.com/traits/bundle-branch-block"
      },
      {
        "slug": "sinoatrial-block",
        "name": "Sinoatrial block",
        "genes": 3,
        "url": "https://dantelabs.com/traits/sinoatrial-block"
      }
    ],
    "genes": [
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "scn1b",
        "symbol": "SCN1B",
        "hgnc": "HGNC:10586",
        "name": "sodium voltage-gated channel beta subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1b"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "trpm4",
        "symbol": "TRPM4",
        "hgnc": "HGNC:17993",
        "name": "transient receptor potential cation channel subfamily M member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpm4"
      },
      {
        "slug": "btnl2",
        "symbol": "BTNL2",
        "hgnc": "HGNC:1142",
        "name": "butyrophilin like 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btnl2"
      },
      {
        "slug": "cdc45",
        "symbol": "CDC45",
        "hgnc": "HGNC:1739",
        "name": "cell division cycle 45",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc45"
      },
      {
        "slug": "cpt2",
        "symbol": "CPT2",
        "hgnc": "HGNC:2330",
        "name": "carnitine palmitoyltransferase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpt2"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "lrp1",
        "symbol": "LRP1",
        "hgnc": "HGNC:6692",
        "name": "LDL receptor related protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp1"
      },
      {
        "slug": "pex7",
        "symbol": "PEX7",
        "hgnc": "HGNC:8860",
        "name": "peroxisomal biogenesis factor 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex7"
      },
      {
        "slug": "phyh",
        "symbol": "PHYH",
        "hgnc": "HGNC:8940",
        "name": "phytanoyl-CoA 2-hydroxylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phyh"
      },
      {
        "slug": "rmrp",
        "symbol": "RMRP",
        "hgnc": "HGNC:10031",
        "name": "RNA component of mitochondrial RNA processing endoribonuclease",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmrp"
      },
      {
        "slug": "ldb3",
        "symbol": "LDB3",
        "hgnc": "HGNC:15710",
        "name": "LIM domain binding 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldb3"
      }
    ]
  }
}