{
  "url": "https://dantelabs.com/traits/glomerular-sclerosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "glomerular-sclerosis",
    "id": "HP:0000096",
    "name": "Glomerular sclerosis",
    "definition": "Accumulation of scar tissue within the glomerulus.",
    "synonyms": [
      "Glomerulosclerosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-renal-glomerulus-morphology",
        "name": "Abnormal renal glomerulus morphology",
        "url": "https://dantelabs.com/traits/abnormal-renal-glomerulus-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "focal-segmental-glomerulosclerosis",
        "name": "Focal segmental glomerulosclerosis",
        "genes": 80,
        "url": "https://dantelabs.com/traits/focal-segmental-glomerulosclerosis"
      },
      {
        "slug": "global-glomerulosclerosis",
        "name": "Global glomerulosclerosis",
        "genes": 4,
        "url": "https://dantelabs.com/traits/global-glomerulosclerosis"
      },
      {
        "slug": "segmental-glomerulosclerosis",
        "name": "Segmental glomerulosclerosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/segmental-glomerulosclerosis"
      }
    ],
    "genes": [
      {
        "slug": "apoa4",
        "symbol": "APOA4",
        "hgnc": "HGNC:602",
        "name": "apolipoprotein A4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoa4"
      },
      {
        "slug": "nos1ap",
        "symbol": "NOS1AP",
        "hgnc": "HGNC:16859",
        "name": "nitric oxide synthase 1 adaptor protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nos1ap"
      },
      {
        "slug": "oas2",
        "symbol": "OAS2",
        "hgnc": "HGNC:8087",
        "name": "2'-5'-oligoadenylate synthetase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oas2"
      },
      {
        "slug": "dlst",
        "symbol": "DLST",
        "hgnc": "HGNC:2911",
        "name": "dihydrolipoamide S-succinyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlst"
      },
      {
        "slug": "dnmt3a",
        "symbol": "DNMT3A",
        "hgnc": "HGNC:2978",
        "name": "DNA methyltransferase 3 alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3a"
      },
      {
        "slug": "epas1",
        "symbol": "EPAS1",
        "hgnc": "HGNC:3374",
        "name": "endothelial PAS domain protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epas1"
      },
      {
        "slug": "fh",
        "symbol": "FH",
        "hgnc": "HGNC:3700",
        "name": "fumarate hydratase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fh"
      },
      {
        "slug": "kif1b",
        "symbol": "KIF1B",
        "hgnc": "HGNC:16636",
        "name": "kinesin family member 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif1b"
      },
      {
        "slug": "max",
        "symbol": "MAX",
        "hgnc": "HGNC:6913",
        "name": "MYC associated transcriptional regulator X",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/max"
      },
      {
        "slug": "mdh2",
        "symbol": "MDH2",
        "hgnc": "HGNC:6971",
        "name": "malate dehydrogenase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdh2"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "hgnc": "HGNC:9967",
        "name": "ret proto-oncogene",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ret"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sdhaf2",
        "symbol": "SDHAF2",
        "hgnc": "HGNC:26034",
        "name": "succinate dehydrogenase complex assembly factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhaf2"
      },
      {
        "slug": "sdhb",
        "symbol": "SDHB",
        "hgnc": "HGNC:10681",
        "name": "succinate dehydrogenase complex iron sulfur subunit B",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sdhb"
      },
      {
        "slug": "sdhc",
        "symbol": "SDHC",
        "hgnc": "HGNC:10682",
        "name": "succinate dehydrogenase complex subunit C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhc"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "slc25a11",
        "symbol": "SLC25A11",
        "hgnc": "HGNC:10981",
        "name": "solute carrier family 25 member 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a11"
      },
      {
        "slug": "tmem127",
        "symbol": "TMEM127",
        "hgnc": "HGNC:26038",
        "name": "transmembrane protein 127",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem127"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "umod",
        "symbol": "UMOD",
        "hgnc": "HGNC:12559",
        "name": "uromodulin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/umod"
      },
      {
        "slug": "vhl",
        "symbol": "VHL",
        "hgnc": "HGNC:12687",
        "name": "von Hippel-Lindau tumor suppressor",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vhl"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "coq8b",
        "symbol": "COQ8B",
        "hgnc": "HGNC:19041",
        "name": "coenzyme Q8B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq8b"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "rnu7-1",
        "symbol": "RNU7-1",
        "hgnc": "HGNC:34033",
        "name": "RNA, U7 small nuclear 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu7-1"
      },
      {
        "slug": "trim8",
        "symbol": "TRIM8",
        "hgnc": "HGNC:15579",
        "name": "tripartite motif containing 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim8"
      },
      {
        "slug": "aptx",
        "symbol": "APTX",
        "hgnc": "HGNC:15984",
        "name": "aprataxin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aptx"
      },
      {
        "slug": "clcn5",
        "symbol": "CLCN5",
        "hgnc": "HGNC:2023",
        "name": "Cl-/H+ antiporter 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn5"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "elp1",
        "symbol": "ELP1",
        "hgnc": "HGNC:5959",
        "name": "elongator acetyltransferase complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elp1"
      },
      {
        "slug": "fah",
        "symbol": "FAH",
        "hgnc": "HGNC:3579",
        "name": "fumarylacetoacetate hydrolase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fah"
      },
      {
        "slug": "muc1",
        "symbol": "MUC1",
        "hgnc": "HGNC:7508",
        "name": "mucin 1, cell surface associated",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/muc1"
      },
      {
        "slug": "nphs1",
        "symbol": "NPHS1",
        "hgnc": "HGNC:7908",
        "name": "NPHS1 adhesion molecule, nephrin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphs1"
      },
      {
        "slug": "osgep",
        "symbol": "OSGEP",
        "hgnc": "HGNC:18028",
        "name": "O-sialoglycoprotein endopeptidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/osgep"
      }
    ]
  }
}