{
  "url": "https://dantelabs.com/traits/ectrodactyly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ectrodactyly",
    "id": "HP:0100257",
    "name": "Cleft hand",
    "label": "Ectrodactyly",
    "definition": "A condition in which middle parts of the hands and/or feet (digits and meta-carpals and -tarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe/fingers over absent 2nd or 3rd toes/fingers as far as oligo- or monodactyl hands and/or feet.",
    "synonyms": [
      "Lobster claw hand"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-limb-bone-morphology",
        "name": "Abnormal shape of limb bone",
        "url": "https://dantelabs.com/traits/abnormal-limb-bone-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "split-hand",
        "name": "Split hand",
        "genes": 64,
        "url": "https://dantelabs.com/traits/split-hand"
      },
      {
        "slug": "split-foot",
        "name": "Split foot",
        "genes": 14,
        "url": "https://dantelabs.com/traits/split-foot"
      }
    ],
    "genes": [
      {
        "slug": "flvcr1",
        "symbol": "FLVCR1",
        "hgnc": "HGNC:24682",
        "name": "FLVCR choline and heme transporter 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flvcr1"
      },
      {
        "slug": "uba2",
        "symbol": "UBA2",
        "hgnc": "HGNC:30661",
        "name": "ubiquitin like modifier activating enzyme 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uba2"
      },
      {
        "slug": "bhlha9",
        "symbol": "BHLHA9",
        "hgnc": "HGNC:35126",
        "name": "basic helix-loop-helix family member a9",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bhlha9"
      },
      {
        "slug": "cdh3",
        "symbol": "CDH3",
        "hgnc": "HGNC:1762",
        "name": "cadherin 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh3"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "wnt7a",
        "symbol": "WNT7A",
        "hgnc": "HGNC:12786",
        "name": "Wnt family member 7A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt7a"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/porcn"
      },
      {
        "slug": "cdkn1c",
        "symbol": "CDKN1C",
        "hgnc": "HGNC:1786",
        "name": "cyclin dependent kinase inhibitor 1C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1c"
      },
      {
        "slug": "hmga2",
        "symbol": "HMGA2",
        "hgnc": "HGNC:5009",
        "name": "high mobility group AT-hook 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmga2"
      },
      {
        "slug": "igf2",
        "symbol": "IGF2",
        "hgnc": "HGNC:5466",
        "name": "insulin like growth factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igf2"
      },
      {
        "slug": "plag1",
        "symbol": "PLAG1",
        "hgnc": "HGNC:9045",
        "name": "PLAG1 zinc finger",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plag1"
      },
      {
        "slug": "wls",
        "symbol": "WLS",
        "hgnc": "HGNC:30238",
        "name": "Wnt ligand secretion mediator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wls"
      },
      {
        "slug": "dlx5",
        "symbol": "DLX5",
        "hgnc": "HGNC:2918",
        "name": "distal-less homeobox 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlx5"
      }
    ]
  }
}