{
  "url": "https://dantelabs.com/traits/cupped-ribs",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cupped-ribs",
    "id": "HP:0000887",
    "name": "Cupped ribs",
    "definition": "Wide, concave rib end.",
    "synonyms": [
      "Rib cupping",
      "Rib flaring"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-rib-morphology",
        "name": "Abnormality of the ribs",
        "url": "https://dantelabs.com/traits/abnormal-rib-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "anterior-rib-cupping",
        "name": "Anterior rib cupping",
        "genes": 20,
        "url": "https://dantelabs.com/traits/anterior-rib-cupping"
      },
      {
        "slug": "posterior-rib-cupping",
        "name": "Posterior rib cupping",
        "genes": 5,
        "url": "https://dantelabs.com/traits/posterior-rib-cupping"
      },
      {
        "slug": "flared-irregular-rib-ends",
        "name": "Flared, irregular rib ends",
        "genes": 1,
        "url": "https://dantelabs.com/traits/flared-irregular-rib-ends"
      }
    ],
    "genes": [
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "hgnc": "HGNC:2187",
        "name": "collagen type XI alpha 2 chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col11a2"
      },
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv4"
      },
      {
        "slug": "ihh",
        "symbol": "IHH",
        "hgnc": "HGNC:5956",
        "name": "Indian hedgehog signaling molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ihh"
      },
      {
        "slug": "pcyt1a",
        "symbol": "PCYT1A",
        "hgnc": "HGNC:8754",
        "name": "phosphate cytidylyltransferase 1A, choline",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pcyt1a"
      },
      {
        "slug": "uba1",
        "symbol": "UBA1",
        "hgnc": "HGNC:12469",
        "name": "ubiquitin like modifier activating enzyme 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uba1"
      },
      {
        "slug": "b3galt6",
        "symbol": "B3GALT6",
        "hgnc": "HGNC:17978",
        "name": "beta-1,3-galactosyltransferase 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b3galt6"
      },
      {
        "slug": "gpx4",
        "symbol": "GPX4",
        "hgnc": "HGNC:4556",
        "name": "glutathione peroxidase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpx4"
      }
    ]
  }
}