{
  "url": "https://dantelabs.com/traits/constitutional-symptom",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "constitutional-symptom",
    "id": "HP:0025142",
    "name": "Constitutional symptom",
    "definition": "A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.",
    "synonyms": [],
    "systems": [],
    "broader": [],
    "narrower": [
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "genes": 501,
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "exercise-intolerance",
        "name": "Decreased ability to exercise",
        "genes": 171,
        "url": "https://dantelabs.com/traits/exercise-intolerance"
      },
      {
        "slug": "pain",
        "name": "Pain",
        "genes": 98,
        "url": "https://dantelabs.com/traits/pain"
      },
      {
        "slug": "malaise",
        "name": "Malaise",
        "genes": 48,
        "url": "https://dantelabs.com/traits/malaise"
      },
      {
        "slug": "gangrene",
        "name": "Death of body tissue due to lack of blood flow or infection",
        "genes": 46,
        "url": "https://dantelabs.com/traits/gangrene"
      },
      {
        "slug": "asthenia",
        "name": "Lack of energy and strength",
        "genes": 27,
        "url": "https://dantelabs.com/traits/asthenia"
      },
      {
        "slug": "sudden-death",
        "name": "Sudden death",
        "genes": 22,
        "url": "https://dantelabs.com/traits/sudden-death"
      },
      {
        "slug": "night-sweats",
        "name": "Night sweats",
        "genes": 21,
        "url": "https://dantelabs.com/traits/night-sweats"
      },
      {
        "slug": "chills",
        "name": "Chills",
        "genes": 19,
        "url": "https://dantelabs.com/traits/chills"
      },
      {
        "slug": "impairment-of-activities-of-daily-living",
        "name": "Impairment of activities of daily living",
        "genes": 11,
        "url": "https://dantelabs.com/traits/impairment-of-activities-of-daily-living"
      },
      {
        "slug": "diminished-health-related-quality-of-life",
        "name": "Diminished health-related quality of life",
        "genes": 10,
        "url": "https://dantelabs.com/traits/diminished-health-related-quality-of-life"
      },
      {
        "slug": "coldness",
        "name": "Coldness",
        "genes": 8,
        "url": "https://dantelabs.com/traits/coldness"
      },
      {
        "slug": "halitosis",
        "name": "Bad breath",
        "genes": 6,
        "url": "https://dantelabs.com/traits/halitosis"
      },
      {
        "slug": "chest-tightness",
        "name": "Chest tightness",
        "genes": 4,
        "url": "https://dantelabs.com/traits/chest-tightness"
      },
      {
        "slug": "shivering",
        "name": "Shivering",
        "genes": 4,
        "url": "https://dantelabs.com/traits/shivering"
      },
      {
        "slug": "body-odor",
        "name": "Body odor",
        "genes": 3,
        "url": "https://dantelabs.com/traits/body-odor"
      },
      {
        "slug": "recurrent-singultus",
        "name": "Hiccup",
        "genes": 3,
        "url": "https://dantelabs.com/traits/recurrent-singultus"
      },
      {
        "slug": "body-ache",
        "name": "Body ache",
        "genes": 1,
        "url": "https://dantelabs.com/traits/body-ache"
      },
      {
        "slug": "hot-flashes",
        "name": "Hot flashes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hot-flashes"
      }
    ],
    "genes": [
      {
        "slug": "asxl1",
        "symbol": "ASXL1",
        "hgnc": "HGNC:18318",
        "name": "ASXL transcriptional regulator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl1"
      },
      {
        "slug": "bap1",
        "symbol": "BAP1",
        "hgnc": "HGNC:950",
        "name": "BRCA1 associated deubiquitinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bap1"
      },
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "cbl",
        "symbol": "CBL",
        "hgnc": "HGNC:1541",
        "name": "Cbl proto-oncogene",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbl"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "runx1",
        "symbol": "RUNX1",
        "hgnc": "HGNC:10471",
        "name": "RUNX family transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx1"
      },
      {
        "slug": "srsf2",
        "symbol": "SRSF2",
        "hgnc": "HGNC:10783",
        "name": "serine and arginine rich splicing factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srsf2"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tet2"
      }
    ]
  }
}