{
  "url": "https://dantelabs.com/traits/absent-toe",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "absent-toe",
    "id": "HP:0010760",
    "name": "Absent toe",
    "definition": "Aplasia of a toe. That is, absence of all phalanges of a non-hallux digit of the foot and the associated soft tissues.",
    "synonyms": [
      "Absent toes",
      "Aplasia of toe"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-toe",
        "name": "Absent/small toe",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-toe"
      }
    ],
    "narrower": [
      {
        "slug": "foot-oligodactyly",
        "name": "Missing toes",
        "genes": 11,
        "url": "https://dantelabs.com/traits/foot-oligodactyly"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-distal-phalanges-of-the-toes",
        "name": "Absent/small outermost bones of toe",
        "genes": 5,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-distal-phalanges-of-the-toes"
      },
      {
        "slug": "adactyly",
        "name": "Absent fingers or toes",
        "genes": 2,
        "url": "https://dantelabs.com/traits/adactyly"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-3rd-toe",
        "name": "Absent/small 3rd toe",
        "genes": 2,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-3rd-toe"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-hallux",
        "name": "Absent/small big toe",
        "genes": 2,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-hallux"
      },
      {
        "slug": "partial-absence-of-toe",
        "name": "Partial absence of toe",
        "genes": 1,
        "url": "https://dantelabs.com/traits/partial-absence-of-toe"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-2nd-toe",
        "name": "Absent/small 2nd toe",
        "genes": 0,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-2nd-toe"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-4th-toe",
        "name": "Absent/small 4th toe",
        "genes": 0,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-4th-toe"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-5th-toe",
        "name": "Absent/small little toe",
        "genes": 0,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-5th-toe"
      }
    ],
    "genes": [
      {
        "slug": "nsdhl",
        "symbol": "NSDHL",
        "hgnc": "HGNC:13398",
        "name": "NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsdhl"
      },
      {
        "slug": "arhgap31",
        "symbol": "ARHGAP31",
        "hgnc": "HGNC:29216",
        "name": "Rho GTPase activating protein 31",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgap31"
      },
      {
        "slug": "dll4",
        "symbol": "DLL4",
        "hgnc": "HGNC:2910",
        "name": "delta like canonical Notch ligand 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dll4"
      },
      {
        "slug": "dock6",
        "symbol": "DOCK6",
        "hgnc": "HGNC:19189",
        "name": "dedicator of cytokinesis 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock6"
      },
      {
        "slug": "eogt",
        "symbol": "EOGT",
        "hgnc": "HGNC:28526",
        "name": "EGF domain specific O-linked N-acetylglucosamine transferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eogt"
      },
      {
        "slug": "lmbr1",
        "symbol": "LMBR1",
        "hgnc": "HGNC:13243",
        "name": "limb development membrane protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmbr1"
      },
      {
        "slug": "notch1",
        "symbol": "NOTCH1",
        "hgnc": "HGNC:7881",
        "name": "notch receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch1"
      },
      {
        "slug": "rbpj",
        "symbol": "RBPJ",
        "hgnc": "HGNC:5724",
        "name": "recombination signal binding protein for immunoglobulin kappa J region",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rbpj"
      },
      {
        "slug": "gdf5",
        "symbol": "GDF5",
        "hgnc": "HGNC:4220",
        "name": "growth differentiation factor 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf5"
      },
      {
        "slug": "dact1",
        "symbol": "DACT1",
        "hgnc": "HGNC:17748",
        "name": "dishevelled binding antagonist of beta catenin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dact1"
      },
      {
        "slug": "eri1",
        "symbol": "ERI1",
        "hgnc": "HGNC:23994",
        "name": "exoribonuclease 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eri1"
      },
      {
        "slug": "sall1",
        "symbol": "SALL1",
        "hgnc": "HGNC:10524",
        "name": "spalt like transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sall1"
      }
    ]
  }
}