{
  "url": "https://dantelabs.com/traits/absent-circulating-b-cells",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "absent-circulating-b-cells",
    "id": "HP:0030252",
    "name": "Absent circulating B cells",
    "definition": "Absence of detectable circulating B cells, commonly characterized as CD19+ or CD20+ lymphocytes, in the blood. Usually, less than 20 cells per microlitre is considered to be an absence.",
    "synonyms": [
      "Absence of mature B cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-total-b-cell-count",
        "name": "Abnormal total B cell count",
        "url": "https://dantelabs.com/traits/abnormal-total-b-cell-count"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cd79a",
        "symbol": "CD79A",
        "hgnc": "HGNC:1698",
        "name": "CD79a molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd79a"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "hgnc": "HGNC:17642",
        "name": "DNA cross-link repair 1C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1c"
      },
      {
        "slug": "fnip1",
        "symbol": "FNIP1",
        "hgnc": "HGNC:29418",
        "name": "folliculin interacting protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fnip1"
      },
      {
        "slug": "igll1",
        "symbol": "IGLL1",
        "hgnc": "HGNC:5870",
        "name": "immunoglobulin lambda like polypeptide 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igll1"
      },
      {
        "slug": "rag1",
        "symbol": "RAG1",
        "hgnc": "HGNC:9831",
        "name": "recombination activating 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag1"
      },
      {
        "slug": "rag2",
        "symbol": "RAG2",
        "hgnc": "HGNC:9832",
        "name": "recombination activating 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag2"
      },
      {
        "slug": "slc39a7",
        "symbol": "SLC39A7",
        "hgnc": "HGNC:4927",
        "name": "solute carrier family 39 member 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc39a7"
      },
      {
        "slug": "spi1",
        "symbol": "SPI1",
        "hgnc": "HGNC:11241",
        "name": "Spi-1 proto-oncogene",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spi1"
      },
      {
        "slug": "top2b",
        "symbol": "TOP2B",
        "hgnc": "HGNC:11990",
        "name": "DNA topoisomerase II beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top2b"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "hgnc": "HGNC:1133",
        "name": "Bruton tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btk"
      },
      {
        "slug": "tnfrsf9",
        "symbol": "TNFRSF9",
        "hgnc": "HGNC:11924",
        "name": "TNF receptor superfamily member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf9"
      }
    ]
  }
}