{
  "url": "https://dantelabs.com/traits/abnormality-of-complement-system",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormality-of-complement-system",
    "id": "HP:0005339",
    "name": "Abnormality of complement system",
    "definition": "An abnormality of the complement system.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-humoral-immunity",
        "name": "Abnormality of humoral immunity",
        "url": "https://dantelabs.com/traits/abnormality-of-humoral-immunity"
      }
    ],
    "narrower": [
      {
        "slug": "reduced-circulating-complement-concentration",
        "name": "Reduced circulating complement concentration",
        "genes": 5,
        "url": "https://dantelabs.com/traits/reduced-circulating-complement-concentration"
      },
      {
        "slug": "decreased-circulating-c1-esterase-inhibitor-concentration",
        "name": "Decreased circulating C1-esterase inhibitor concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-c1-esterase-inhibitor-concentration"
      },
      {
        "slug": "abnormal-total-hemolytic-complement-activity",
        "name": "Abnormal total hemolytic complement activity",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-total-hemolytic-complement-activity"
      },
      {
        "slug": "abnormality-of-the-alternative-complement-pathway",
        "name": "Abnormality of the alternative complement pathway",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormality-of-the-alternative-complement-pathway"
      }
    ],
    "genes": [
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "c1s",
        "symbol": "C1S",
        "hgnc": "HGNC:1247",
        "name": "complement C1s",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1s"
      }
    ]
  }
}