{
  "url": "https://dantelabs.com/traits/abnormal-iris-pigmentation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-iris-pigmentation",
    "id": "HP:0008034",
    "name": "Abnormal iris pigmentation",
    "definition": "Abnormal pigmentation of the iris.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-iris-morphology",
        "name": "Abnormality of the iris",
        "url": "https://dantelabs.com/traits/abnormality-iris-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "blue-irides",
        "name": "Blue eyes",
        "genes": 57,
        "url": "https://dantelabs.com/traits/blue-irides"
      },
      {
        "slug": "iris-hypopigmentation",
        "name": "Light eye color",
        "genes": 34,
        "url": "https://dantelabs.com/traits/iris-hypopigmentation"
      },
      {
        "slug": "iris-transillumination-defect",
        "name": "Iris transillumination defect",
        "genes": 14,
        "url": "https://dantelabs.com/traits/iris-transillumination-defect"
      },
      {
        "slug": "brushfield-spots",
        "name": "Speckled iris",
        "genes": 14,
        "url": "https://dantelabs.com/traits/brushfield-spots"
      },
      {
        "slug": "stellate-iris",
        "name": "Stellate iris",
        "genes": 3,
        "url": "https://dantelabs.com/traits/stellate-iris"
      },
      {
        "slug": "asymmetry-of-iris-pigmentation",
        "name": "Asymmetry of iris pigmentation",
        "genes": 0,
        "url": "https://dantelabs.com/traits/asymmetry-of-iris-pigmentation"
      }
    ],
    "genes": [
      {
        "slug": "slc24a5",
        "symbol": "SLC24A5",
        "hgnc": "HGNC:20611",
        "name": "solute carrier family 24 member 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc24a5"
      },
      {
        "slug": "lmx1b",
        "symbol": "LMX1B",
        "hgnc": "HGNC:6654",
        "name": "LIM homeobox transcription factor 1 beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmx1b"
      },
      {
        "slug": "myh11",
        "symbol": "MYH11",
        "hgnc": "HGNC:7569",
        "name": "myosin heavy chain 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh11"
      },
      {
        "slug": "tyrp1",
        "symbol": "TYRP1",
        "hgnc": "HGNC:12450",
        "name": "tyrosinase related protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyrp1"
      }
    ]
  }
}