{
  "url": "https://dantelabs.com/traits/abnormal-double-negative-t-cell-proportion",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-double-negative-t-cell-proportion",
    "id": "HP:0031399",
    "name": "Abnormal double-negative T cell proportion",
    "definition": "Abnormal increase or decrease of double-negative (DN) CD3+CD4-CD8- T cells, measured either as percentage of total CD3+ T cells in the blood, or as absolute number per microliter of blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.",
    "synonyms": [
      "Abnormal CD4-negative, CD8-negative regulatory T cell distribution",
      "Abnormal DN Treg distribution",
      "Abnormal Double negative Treg distribution",
      "Abnormal double-negative regulatory T cell distribution",
      "Abnormal proportion of double-negative regulatory T cell"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-t-cell-subset-number",
        "name": "Abnormal T cell subset number",
        "url": "https://dantelabs.com/traits/abnormal-t-cell-subset-number"
      }
    ],
    "narrower": [
      {
        "slug": "increased-double-negative-t-cell-number",
        "name": "Increased double-negative T cell number",
        "genes": 5,
        "url": "https://dantelabs.com/traits/increased-double-negative-t-cell-number"
      },
      {
        "slug": "decreased-double-negative-t-cell-number",
        "name": "Decreased double-negative T cell number",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-double-negative-t-cell-number"
      }
    ],
    "genes": []
  }
}