{
  "url": "https://dantelabs.com/traits/abnormal-circulating-leptin-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-leptin-concentration",
    "id": "HP:0004361",
    "name": "Abnormal circulating leptin concentration",
    "definition": "An abnormal concentration of leptin in the blood.",
    "synonyms": [
      "Abnormality of circulating leptin level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-hormone-concentration",
        "name": "Abnormality of circulating hormone level",
        "url": "https://dantelabs.com/traits/abnormal-circulating-hormone-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-serum-leptin",
        "name": "Decreased serum leptin",
        "genes": 11,
        "url": "https://dantelabs.com/traits/decreased-serum-leptin"
      },
      {
        "slug": "increased-serum-leptin",
        "name": "Increased serum leptin",
        "genes": 2,
        "url": "https://dantelabs.com/traits/increased-serum-leptin"
      }
    ],
    "genes": [
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      }
    ]
  }
}