{ "url": "https://dantelabs.com/ro/genes/wnt10b", "gene": { "slug": "wnt10b", "symbol": "WNT10B", "name": "Wnt family member 10B", "hgnc": "HGNC:12775", "summary": null, "location": "12q13.12", "locusType": "gene with protein product", "aliases": [ "WNT-12", "SHFM6" ], "previousSymbols": [], "ensemblId": "ENSG00000169884", "entrezId": 7480, "omim": [ "601906" ], "uniprot": [ "O00744" ], "model": { "build": "GRCh38", "release": "v1.5", "chrom": "12", "start": 48965340, "end": 48971735, "strand": "-", "ensemblTranscript": "ENST00000301061.9", "refseqTranscript": "NM_003394.4", "ensemblProtein": "ENSP00000301061.4", "refseqProtein": "NP_003385.2", "exons": [ { "start": 48965340, "end": 48966553 }, { "start": 48967946, "end": 48968319 }, { "start": 48970089, "end": 48970351 }, { "start": 48970456, "end": 48970569 }, { "start": 48971455, "end": 48971735 } ], "cds": { "start": 48966095, "end": 48970529 } }, "grch37": { "build": "GRCh37", "release": "87", "chrom": "12", "start": 49359123, 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"ENSG00000134287", "biotype": "protein_coding", "start": 48903141, "end": 48957531, "strand": "-", "slug": "arf3" }, { "symbol": "", "ensemblId": "ENSG00000272822", "biotype": "protein_coding", "start": 48903503, "end": 48957365, "strand": "-" }, { "symbol": "DRC2", "ensemblId": "ENSG00000139537", "biotype": "protein_coding", "start": 48904105, "end": 48931840, "strand": "+", "slug": "drc2" }, { "symbol": "FKBP11", "ensemblId": "ENSG00000134285", "biotype": "protein_coding", "start": 48921518, "end": 48927909, "strand": "-", "slug": "fkbp11" }, { "symbol": "WNT1", "ensemblId": "ENSG00000125084", "biotype": "protein_coding", "start": 48978322, "end": 48982620, "strand": "+", "slug": "wnt1" }, { "symbol": "DDN", "ensemblId": "ENSG00000181418", "biotype": "protein_coding", "start": 48995149, "end": 48999375, "strand": "-", "slug": "ddn" }, { "symbol": "PRKAG1", "ensemblId": "ENSG00000181929", "biotype": "protein_coding", "start": 49002272, "end": 49018820, "strand": "-", "slug": "prkag1" }, { "symbol": "", "ensemblId": "ENSG00000288710", "biotype": "protein_coding", "start": 49002274, "end": 49024075, "strand": "-" }, { "symbol": "KMT2D", "ensemblId": "ENSG00000167548", "biotype": "protein_coding", "start": 49018975, "end": 49060794, "strand": "-", "slug": "kmt2d" }, { "symbol": "RHEBL1", "ensemblId": "ENSG00000167550", "biotype": "protein_coding", "start": 49064675, "end": 49070127, "strand": "-", "slug": "rhebl1" }, { "symbol": "DHH", "ensemblId": "ENSG00000139549", "biotype": "protein_coding", "start": 49086656, "end": 49094807, "strand": "-", "slug": "dhh" }, { "symbol": "LMBR1L", "ensemblId": "ENSG00000139636", "biotype": "protein_coding", "start": 49096550, "end": 49110900, "strand": "-", "slug": "lmbr1l" }, { "symbol": "TUBA1B", "ensemblId": "ENSG00000123416", "biotype": "protein_coding", "start": 49127780, "end": 49131398, "strand": "-", "slug": "tuba1b" }, { "symbol": "TUBA1A", "ensemblId": "ENSG00000167552", "biotype": "protein_coding", "start": 49184146, "end": 49189324, "strand": "-", "slug": "tuba1a" }, { "symbol": "TUBA1C", "ensemblId": "ENSG00000167553", "biotype": "protein_coding", "start": 49188736, "end": 49274600, "strand": "+", "slug": "tuba1c" }, { "symbol": "PRPH", "ensemblId": "ENSG00000135406", "biotype": "protein_coding", "start": 49295141, "end": 49298686, "strand": "+", "slug": "prph" }, { "symbol": "TROAP", "ensemblId": "ENSG00000135451", "biotype": "protein_coding", "start": 49323165, "end": 49331735, "strand": "+", "slug": "troap" }, { "symbol": "C1QL4", "ensemblId": "ENSG00000186897", "biotype": "protein_coding", "start": 49332409, "end": 49337227, "strand": "-", "slug": "c1ql4" }, { "symbol": "DNAJC22", "ensemblId": "ENSG00000178401", "biotype": "protein_coding", "start": 49345607, "end": 49357546, "strand": "+", "slug": "dnajc22" }, { "symbol": "SPATS2", "ensemblId": "ENSG00000123352", "biotype": "protein_coding", "start": 49366240, "end": 49528438, "strand": "+", "slug": "spats2" } ], "truncated": false }, "reports": [ { "slug": "hypodontia-and-anodontia", "name": "Hipodonție și anodonție", "diseases": [ { "mondoId": "MONDO:0005486", "name": "Agenezia dentară (hipodonție)", "genes": 7, "inheritance": null, "description": null, "management": null, "evidence": { "gencc": [ "PanelApp Australia" ], "acmgSf": false, "inheritance": [ "autosomal-dominant" ] }, "sameAsReport": false, "broad": false } ], "url": "https://dantelabs.com/ro/conditions/hypodontia-and-anodontia" } ], "pharmacogenomics": [], "traits": [], "phenotypes": [ { "slug": "abnormal-canine-tooth-morphology", "name": "Abnormality of canine", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormal-canine-tooth-morphology" }, { "slug": "abnormal-dental-morphology", "name": "Abnormality of dental shape", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormal-dental-morphology" }, { "slug": "abnormal-primary-molar-morphology", "name": "Abnormality of shape of baby molar", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormal-primary-molar-morphology" }, { "slug": "selective-tooth-agenesis", "name": "Absence of a tooth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/selective-tooth-agenesis" }, { "slug": "agenesis-of-mandibular-premolar", "name": "Absence of lower premolar", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/agenesis-of-mandibular-premolar" }, { "slug": "agenesis-of-premolar", "name": "Absence of premolar", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/agenesis-of-premolar" }, { "slug": "agenesis-of-first-permanent-molar-tooth", "name": "Absence of six year molar", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/agenesis-of-first-permanent-molar-tooth" }, { "slug": "agenesis-of-maxillary-lateral-incisor", "name": "Absence of upper lateral incisor", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/agenesis-of-maxillary-lateral-incisor" }, { "slug": "agenesis-of-central-incisor", "name": "Absent central incisor", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/agenesis-of-central-incisor" }, { "slug": "finger-aplasia", "name": "Absent fingers", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "url": "https://dantelabs.com/traits/finger-aplasia" }, { "slug": "absent-hand", "name": "Absent hand", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/absent-hand" }, { "slug": "aniridia", "name": "Absent iris", "systems": [ "abnormality-of-the-eye" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/aniridia" }, { "slug": "dental-malocclusion", "name": "Bad bite", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/dental-malocclusion" }, { "slug": "impaired-mastication", "name": "Chewing difficulties", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/impaired-mastication" }, { "slug": "orofacial-cleft", "name": "Cleft of the mouth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/orofacial-cleft" }, { "slug": "short-dental-root", "name": "Decreased length of dental roots", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/short-dental-root" }, { "slug": "hypoplasia-of-teeth", "name": "Decreased size of teeth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/hypoplasia-of-teeth" }, { "slug": "microdontia", "name": "Decreased size of tooth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/microdontia" }, { "slug": "delayed-eruption-of-permanent-teeth", "name": "Delayed eruption of permanent teeth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/delayed-eruption-of-permanent-teeth" }, { "slug": "delayed-eruption-of-teeth", "name": "Delayed eruption of teeth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/delayed-eruption-of-teeth" }, { "slug": "dry-skin", "name": "Dry skin", "systems": [ "abnormality-of-the-integument" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/dry-skin" }, { "slug": "oligodontia", "name": "Failure of development of more than six teeth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/oligodontia" }, { "slug": "finger-syndactyly", "name": "Finger syndactyly", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/finger-syndactyly" }, { "slug": "toe-syndactyly", "name": "Fused toes", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "url": "https://dantelabs.com/traits/toe-syndactyly" }, { "slug": "hand-monodactyly", "name": "Hand monodactyly", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/hand-monodactyly" }, { "slug": "foot-oligodactyly", "name": "Missing toes", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "url": "https://dantelabs.com/traits/foot-oligodactyly" }, { "slug": "oligodactyly", "name": "Oligodactyly", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/oligodactyly" }, { "slug": "eclabion", "name": "Outward turned lips", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/eclabion" }, { "slug": "peg-shaped-maxillary-lateral-incisors", "name": "Peg-shaped maxillary lateral incisors", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/peg-shaped-maxillary-lateral-incisors" }, { "slug": "sensorineural-hearing-impairment", "name": "Sensorineural hearing impairment", "systems": [ "abnormality-of-the-ear" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment" }, { "slug": "short-face", "name": "Short face", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/short-face" }, { "slug": "sparse-eyebrow", "name": "Sparse eyebrow", "systems": [ "abnormality-of-head-or-neck", "abnormality-of-the-integument" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/sparse-eyebrow" }, { "slug": "sparse-hair", "name": "Sparse hair", "systems": [ "abnormality-of-the-integument" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/sparse-hair" }, { "slug": "split-foot", "name": "Split foot", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/split-foot" }, { "slug": "split-hand", "name": "Split hand", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/split-hand" }, { "slug": "taurodontia", "name": "Taurodontia", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/taurodontia" }, { "slug": "enamel-hypoplasia", "name": "Thin dental enamel", "systems": [ "abnormality-of-head-or-neck", "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/enamel-hypoplasia" }, { "slug": "widely-spaced-teeth", "name": "Widely spaced teeth", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/widely-spaced-teeth" } ], "related": [ { "slug": "eda", "symbol": "EDA", "name": "ectodysplasin A", "shared": 1, "url": "https://dantelabs.com/ro/genes/eda" }, { "slug": "lrp6", "symbol": "LRP6", "name": "LDL receptor related protein 6", "shared": 1, "url": "https://dantelabs.com/ro/genes/lrp6" }, { "slug": "msx1", "symbol": "MSX1", "name": "msh homeobox 1", "shared": 1, "url": "https://dantelabs.com/ro/genes/msx1" }, { "slug": "pax9", "symbol": "PAX9", "name": "paired box 9", "shared": 1, "url": "https://dantelabs.com/ro/genes/pax9" }, { "slug": "tspear", "symbol": "TSPEAR", "name": "thrombospondin type laminin G domain and EAR repeats", "shared": 1, "url": "https://dantelabs.com/ro/genes/tspear" }, { "slug": "wnt10a", "symbol": "WNT10A", "name": "Wnt family member 10A", "shared": 1, "url": "https://dantelabs.com/ro/genes/wnt10a" } ], "sources": { "bundleId": "2026.10.17-8666dff2", "panel": "2026-10-17", "acmgSf": "SF v3.2" }, "locusKind": "proteinCoding" }, "variants": { "total": 0, "url": null, "items": [] } }