{ "url": "https://dantelabs.com/ro/genes/rpgr", "gene": { "slug": "rpgr", "symbol": "RPGR", "name": "retinitis pigmentosa GTPase regulator", "hgnc": "HGNC:10295", "summary": null, "location": "Xp11.4", "locusType": "gene with protein product", "aliases": [ "CORDX1" ], "previousSymbols": [ "CRD", "RP3", "RP15", "COD1" ], "ensemblId": "ENSG00000156313", "entrezId": 6103, "omim": [ "312610" ], "uniprot": [ "Q92834" ], "model": { "build": "GRCh38", "release": "v1.5", "chrom": "X", "start": 38284408, "end": 38327509, "strand": "-", "ensemblTranscript": "ENST00000645032.1", "refseqTranscript": "NM_001034853.2", "ensemblProtein": "ENSP00000495537.1", "refseqProtein": "NP_001030025.1", "exons": [ { "start": 38284408, "end": 38287245 }, { "start": 38287861, "end": 38288041 }, { "start": 38290959, "end": 38291024 }, { "start": 38291393, "end": 38291484 }, { "start": 38297284, "end": 38297452 }, { "start": 38298956, "end": 38299141 }, { "start": 38301247, "end": 38301371 }, { "start": 38304635, "end": 38304790 }, { "start": 38310615, "end": 38310773 }, { "start": 38317316, "end": 38317465 }, { "start": 38318829, "end": 38318987 }, { "start": 38321027, "end": 38321089 }, { "start": 38322853, "end": 38322945 }, { "start": 38323399, "end": 38323524 }, { "start": 38327340, "end": 38327509 } ], "cds": { "start": 38285540, "end": 38327367 } }, "grch37": { "build": "GRCh37", "release": "87", "chrom": "X", "start": 38128416, "end": 38186817, "strand": "-" }, "neighbourhood": { "release": "116", "start": 37805959, "end": 38805958, "genes": [ { "symbol": "", "ensemblId": "ENSG00000250349", "biotype": "protein_coding", "start": 37349330, "end": 38687674, "strand": "+" }, { "symbol": "CYBB", "ensemblId": "ENSG00000165168", "biotype": "protein_coding", "start": 37780018, "end": 37816994, "strand": "+", "slug": "cybb" }, { "symbol": "DYNLT3", "ensemblId": "ENSG00000165169", "biotype": "protein_coding", "start": 37836611, "end": 37847593, "strand": "-", "slug": "dynlt3" }, { "symbol": "H2AP", "ensemblId": "ENSG00000187516", "biotype": "protein_coding", "start": 37990779, "end": 37991314, "strand": "+", "slug": "h2ap" }, { "symbol": "H2AL3", "ensemblId": "ENSG00000229674", "biotype": "protein_coding", "start": 37994272, "end": 37994904, "strand": "+", "slug": "h2al3" }, { "symbol": "SYTL5", "ensemblId": "ENSG00000147041", "biotype": "protein_coding", "start": 38006515, "end": 38128964, "strand": "+", "slug": "sytl5" }, { "symbol": "SRPX", "ensemblId": "ENSG00000101955", "biotype": "protein_coding", "start": 38149336, "end": 38220941, "strand": "-", "slug": "srpx" }, { "symbol": "OTC", "ensemblId": "ENSG00000036473", "biotype": "protein_coding", "start": 38327598, "end": 38424632, "strand": "+", "slug": "otc" }, { "symbol": "TSPAN7", "ensemblId": "ENSG00000156298", "biotype": "protein_coding", "start": 38561498, "end": 38689249, "strand": "+", "slug": "tspan7" }, { "symbol": "MID1IP1", "ensemblId": "ENSG00000165175", "biotype": "protein_coding", "start": 38801417, "end": 38806555, "strand": "+", "slug": "mid1ip1" } ], "truncated": false }, "reports": [ { "slug": "retinitis-pigmentosa", "name": "Retinita pigmentară", "diseases": [ { "mondoId": "MONDO:0100437", "name": "Retinopatie legată de RPGR", "genes": 1, "inheritance": "x-linked-recessive", "description": "O distrofie retiniană cauzată de modificări ale genei RPGR, cea mai frecventă cauză a retinitei pigmentare legate de cromozomul X.", "management": null, "evidence": { "gencc": [ "Ambry Genetics", "ClinGen", "G2P", "Labcorp Genetics (formerly Invitae)", "PanelApp Australia" ], "clingen": "Definitive", "acmgSf": false, "inheritance": [] }, "sameAsReport": false, "broad": false }, { "mondoId": "MONDO:0019200", "name": "Retinita pigmentară", "genes": 77, "inheritance": null, "description": "Un grup de distrofii retiniene ereditare cu pierdere progresivă a bastonaşelor, apoi a conurilor fotoreceptoare, cauzând cecitate nocturnă și pierderea treptată a vederii periferice.", "management": null, "evidence": { "gencc": [ "Ambry Genetics", "G2P", "Labcorp Genetics (formerly Invitae)", "PanelApp Australia" ], "acmgSf": false, "inheritance": [] }, "sameAsReport": true, "broad": true } ], "url": "https://dantelabs.com/ro/conditions/retinitis-pigmentosa" } ], "pharmacogenomics": [], "traits": [], "phenotypes": [ { "slug": "abnormal-cardiovascular-system-morphology", "name": "Abnormal cardiovascular system morphology", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormal-cardiovascular-system-morphology" }, { "slug": "abnormal-central-response-of-multifocal-electroretinogram", "name": "Abnormal central response of multifocal electroretinogram", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/abnormal-central-response-of-multifocal-electroretinogram" }, { "slug": "color-vision-defect", "name": "Abnormal color vision", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/color-vision-defect" }, { "slug": "abnormal-electroretinogram", "name": "Abnormal electroretinogram", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/abnormal-electroretinogram" }, { "slug": "abnormal-full-field-electroretinogram", "name": "Abnormal full-field electroretinogram", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/abnormal-full-field-electroretinogram" }, { "slug": "abnormal-inferior-vena-cava-morphology", "name": "Abnormal inferior vena cava morphology", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/abnormal-inferior-vena-cava-morphology" }, { "slug": "abnormal-atrial-arrangement", "name": "Abnormal location of heart atrium", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/abnormal-atrial-arrangement" }, { "slug": "abnormal-macular-morphology", "name": "Abnormal macular morphology", "systems": [ "abnormality-of-the-eye" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormal-macular-morphology" }, { "slug": "abnormal-pupillary-light-reflex", "name": "Abnormal pupillary light reflex", "systems": [ "abnormality-of-the-eye" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormal-pupillary-light-reflex" }, { "slug": "abnormal-retinal-pigmentation", "name": "Abnormal retinal pigmentation", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/abnormal-retinal-pigmentation" }, { "slug": "abnormal-sperm-motility", "name": "Abnormal sperm motility", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/abnormal-sperm-motility" }, { "slug": "abnormal-sputum", "name": "Abnormal sputum", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/abnormal-sputum" }, { "slug": "abnormality-of-refraction", "name": "Abnormality of refraction", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/abnormality-of-refraction" }, { "slug": "abnormal-retinal-vascular-morphology", "name": "Abnormality of retina blood vessels", "systems": [ "abnormality-of-the-cardiovascular-system", "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/abnormal-retinal-vascular-morphology" }, { "slug": "abnormality-of-the-genitourinary-system", "name": "Abnormality of the genitourinary system", "systems": [], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system" }, { "slug": "abnormal-heart-morphology", "name": "Abnormality of the heart", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormal-heart-morphology" }, { "slug": "abnormality-of-the-skeletal-system", "name": "Abnormality of the skeletal system", "systems": [ "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/abnormality-of-the-skeletal-system" }, { "slug": "absent-foveal-reflex", "name": "Absent foveal reflex", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/absent-foveal-reflex" }, { "slug": "asplenia", "name": "Absent spleen", "systems": [ "abnormality-of-the-cardiovascular-system", "abnormality-of-the-digestive-system", "abnormality-of-the-immune-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/asplenia" }, { "slug": "situs-inversus-totalis", "name": "All organs on wrong side of body", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/situs-inversus-totalis" }, { "slug": "anomalous-pulmonary-venous-return", "name": "Anomalous pulmonary venous return", "systems": [ "abnormality-of-the-cardiovascular-system", "abnormality-of-the-respiratory-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/anomalous-pulmonary-venous-return" }, { "slug": "atrial-situs-ambiguous", "name": "Atrial situs ambiguous", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/atrial-situs-ambiguous" }, { "slug": "central-scotoma", "name": "Blind spot located at fixation point", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/central-scotoma" }, { "slug": "blindness", "name": "Blindness", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/blindness" }, { "slug": "nasal-congestion", "name": "Blockage of nose", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/nasal-congestion" }, { "slug": "keratoconus", "name": "Bulging cornea", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/keratoconus" }, { "slug": "chronic-otitis-media", "name": "Chronic infections of the middle ear", "systems": [ "abnormality-of-the-ear", "abnormality-of-the-immune-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/chronic-otitis-media" }, { "slug": "chronic-rhinitis", "name": "Chronic rhinitis", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/chronic-rhinitis" }, { "slug": "chronic-sinusitis", "name": "Chronic sinus disease", "systems": [ "abnormality-of-head-or-neck", "abnormality-of-the-immune-system", "abnormality-of-the-musculoskeletal-system", "abnormality-of-the-respiratory-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/chronic-sinusitis" }, { "slug": "myopia", "name": "Close sighted", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/myopia" }, { "slug": "clubbing", "name": "Clubbing of fingers and toes", "systems": [ "abnormality-of-limbs", "abnormality-of-the-musculoskeletal-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/clubbing" }, { "slug": "dyschromatopsia", "name": "Color blindness", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/dyschromatopsia" }, { "slug": "color-vision-test-abnormality", "name": "Color vision test abnormality", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/color-vision-test-abnormality" }, { "slug": "conductive-hearing-impairment", "name": "Conductive deafness", "systems": [ "abnormality-of-the-ear" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/conductive-hearing-impairment" }, { "slug": "cystoid-macular-edema", "name": "Cystoid macular edema", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/cystoid-macular-edema" }, { "slug": "reduced-visual-acuity", "name": "Decreased clarity of vision", "systems": [ "abnormality-of-the-eye" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/reduced-visual-acuity" }, { "slug": "delayed-speech-and-language-development", "name": "Delayed speech and language development", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/delayed-speech-and-language-development" }, { "slug": "nyctalopia", "name": "Difficulties with night vision", "systems": [ "abnormality-of-the-eye" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/nyctalopia" }, { "slug": "double-outlet-right-ventricle", "name": "Double outlet right ventricle", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/double-outlet-right-ventricle" }, { "slug": "eccentric-visual-fixation", "name": "Eccentric visual fixation", "systems": [ "abnormality-of-the-eye" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/eccentric-visual-fixation" }, { "slug": "photophobia", "name": "Extreme sensitivity of the eyes to light", "systems": [ "abnormality-of-the-eye", "abnormality-of-the-nervous-system" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/photophobia" }, { "slug": "ophthalmoplegia", "name": "Eye muscle paralysis", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/ophthalmoplegia" }, { "slug": "hypermetropia", "name": "Farsightedness", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/hypermetropia" }, { "slug": "female-infertility", "name": "Female infertility", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/female-infertility" }, { "slug": "glaucoma", "name": "Glaucoma", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/glaucoma" }, { "slug": "hearing-impairment", "name": "Hearing impairment", "systems": [ "abnormality-of-the-ear" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/hearing-impairment" }, { "slug": "high-frequency-hearing-impairment", "name": "Hearing loss, high-frequency", "systems": [ "abnormality-of-the-ear" ], "url": "https://dantelabs.com/traits/high-frequency-hearing-impairment" }, { "slug": "hyperinsulinemia", "name": "Hyperinsulinemia", "systems": [ "abnormality-of-metabolism-homeostasis", "abnormality-of-the-endocrine-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/hyperinsulinemia" }, { "slug": "hypoautofluorescent-macular-lesion", "name": "Hypoautofluorescent macular lesion", "systems": [ "abnormality-of-the-eye" ], "url": "https://dantelabs.com/traits/hypoautofluorescent-macular-lesion" }, { "slug": "hypoplasia-of-the-fovea", "name": "Hypoplasia of the fovea", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/hypoplasia-of-the-fovea" }, { "slug": "inner-retinal-layer-loss-on-macular-oct", "name": "Inner retinal layer loss on macular OCT", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/inner-retinal-layer-loss-on-macular-oct" }, { "slug": "intestinal-malrotation", "name": "Intestinal malrotation", "systems": [ "abnormality-of-the-digestive-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/intestinal-malrotation" }, { "slug": "nystagmus", "name": "Involuntary, rapid, rhythmic eye movements", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/nystagmus" }, { "slug": "constriction-of-peripheral-visual-field", "name": "Limited peripheral vision", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/constriction-of-peripheral-visual-field" }, { "slug": "lithoptysis", "name": "Lithoptysis", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/lithoptysis" }, { "slug": "peripheral-visual-field-loss", "name": "Loss of peripheral vision", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/peripheral-visual-field-loss" }, { "slug": "macular-degeneration", "name": "Macular degeneration", "systems": [ "abnormality-of-the-eye" ], "url": "https://dantelabs.com/traits/macular-degeneration" }, { "slug": "male-infertility", "name": "Male infertility", "systems": [ "abnormality-of-the-genitourinary-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/male-infertility" }, { "slug": "metamorphopsia", "name": "Metamorphopsia", "systems": [ "abnormality-of-the-eye" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/metamorphopsia" }, { "slug": "otitis-media", "name": "Middle ear infection", "systems": [ "abnormality-of-the-ear", "abnormality-of-the-immune-system" ], "url": "https://dantelabs.com/traits/otitis-media" }, { "slug": "morphological-central-nervous-system-abnormality", "name": "Morphological central nervous system abnormality", "systems": [ "abnormality-of-the-nervous-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/morphological-central-nervous-system-abnormality" }, { "slug": "polysplenia", "name": "Multiple small spleens", "systems": [ "abnormality-of-the-cardiovascular-system", "abnormality-of-the-digestive-system", "abnormality-of-the-immune-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/polysplenia" }, { "slug": "attenuation-of-retinal-blood-vessels", "name": "Narrowing of blood vessels in back of eye", "systems": [ "abnormality-of-the-cardiovascular-system", "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/attenuation-of-retinal-blood-vessels" }, { "slug": "nasal-polyposis", "name": "Nasal polyposis", "systems": [ "abnormality-of-head-or-neck" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/nasal-polyposis" }, { "slug": "neonatal-respiratory-distress", "name": "Neonatal respiratory distress", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/neonatal-respiratory-distress" }, { "slug": "airway-obstruction", "name": "Obstructive lung disease", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/airway-obstruction" }, { "slug": "optic-atrophy", "name": "Optic atrophy", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/optic-atrophy" }, { "slug": "optic-disc-drusen", "name": "Optic disc drusen", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/optic-disc-drusen" }, { "slug": "optic-disc-pallor", "name": "Optic disc pallor", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/optic-disc-pallor" }, { "slug": "atelectasis", "name": "Partial or complete collapse of part or entire lung", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/atelectasis" }, { "slug": "pendular-nystagmus", "name": "Pendular nystagmus", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/pendular-nystagmus" }, { "slug": "peribronchovascular-interstitial-thickening", "name": "Peribronchovascular interstitial thickening", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/peribronchovascular-interstitial-thickening" }, { "slug": "perifoveal-hypoautofluorescence", "name": "Perifoveal hypoautofluorescence", "systems": [ "abnormality-of-the-eye" ], "frequency": "obligate", "url": "https://dantelabs.com/traits/perifoveal-hypoautofluorescence" }, { "slug": "bronchiectasis", "name": "Permanent enlargement of the airways of the lungs", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/bronchiectasis" }, { "slug": "persistent-left-superior-vena-cava", "name": "Persistent left superior vena cava", "systems": [ "abnormality-of-the-cardiovascular-system" ], "frequency": "very-rare", "url": "https://dantelabs.com/traits/persistent-left-superior-vena-cava" }, { "slug": "photopsia", "name": "Photopsia", "systems": [ "abnormality-of-the-eye" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/photopsia" }, { "slug": "photoreceptor-outer-segment-loss-on-macular-oct", "name": "Photoreceptor outer segment loss on macular OCT", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/photoreceptor-outer-segment-loss-on-macular-oct" }, { "slug": "posterior-subcapsular-cataract", "name": "Posterior subcapsular cataract", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/posterior-subcapsular-cataract" }, { "slug": "progressive-visual-loss", "name": "Progressive loss of vision", "systems": [ "abnormality-of-the-eye" ], "frequency": "frequent", "url": "https://dantelabs.com/traits/progressive-visual-loss" }, { "slug": "progressive-night-blindness", "name": "Progressive night blindness", "systems": [ "abnormality-of-the-eye" ], "frequency": "very-frequent", "url": "https://dantelabs.com/traits/progressive-night-blindness" }, { "slug": "pulmonary-situs-ambiguus", "name": "Pulmonary situs ambiguus", "systems": [ "abnormality-of-the-respiratory-system" ], "frequency": "occasional", "url": "https://dantelabs.com/traits/pulmonary-situs-ambiguus" }, { "slug": "recurrent-bronchitis", "name": "Recurrent bronchitis", "systems": [ "abnormality-of-the-immune-system", "abnormality-of-the-respiratory-system" ], "url": "https://dantelabs.com/traits/recurrent-bronchitis" }, { "slug": "recurrent-haemophilus-influenzae-infection", "name": "Recurrent Haemophilus influenzae infection", "systems": [ "abnormality-of-the-immune-system" ], "url": "https://dantelabs.com/traits/recurrent-haemophilus-influenzae-infection" }, { "slug": "recurrent-otitis-media", "name": "Recurrent middle ear infection", "systems": [ "abnormality-of-the-ear", "abnormality-of-the-immune-system" ], "frequency": "frequent", "url": 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