{
  "url": "https://dantelabs.com/ro/genes/ntrk1",
  "gene": {
    "slug": "ntrk1",
    "symbol": "NTRK1",
    "name": "neurotrophic receptor tyrosine kinase 1",
    "hgnc": "HGNC:8031",
    "summary": null,
    "location": "1q23.1",
    "locusType": "gene with protein product",
    "aliases": [
      "TRK",
      "TRKA",
      "MTC"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000198400",
    "entrezId": 4914,
    "omim": [
      "191315"
    ],
    "uniprot": [
      "P04629"
    ],
    "model": {
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      "release": "v1.5",
      "chrom": "1",
      "start": 156860865,
      "end": 156881850,
      "strand": "+",
      "ensemblTranscript": "ENST00000524377.7",
      "refseqTranscript": "NM_002529.4",
      "ensemblProtein": "ENSP00000431418.1",
      "refseqProtein": "NP_002520.2",
      "exons": [
        {
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        },
        {
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        },
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        }
      ],
      "cds": {
        "start": 156860935,
        "end": 156881642
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "1",
      "start": 156785432,
      "end": 156851642,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 156371358,
      "end": 157371357,
      "genes": [
        {
          "symbol": "RHBG",
          "ensemblId": "ENSG00000132677",
          "biotype": "protein_coding",
          "start": 156369015,
          "end": 156385221,
          "strand": "+",
          "slug": "rhbg"
        },
        {
          "symbol": "MEF2D",
          "ensemblId": "ENSG00000116604",
          "biotype": "protein_coding",
          "start": 156463727,
          "end": 156501266,
          "strand": "-",
          "slug": "mef2d"
        },
        {
          "symbol": "IQGAP3",
          "ensemblId": "ENSG00000183856",
          "biotype": "protein_coding",
          "start": 156525405,
          "end": 156572604,
          "strand": "-",
          "slug": "iqgap3"
        },
        {
          "symbol": "TTC24",
          "ensemblId": "ENSG00000187862",
          "biotype": "protein_coding",
          "start": 156579723,
          "end": 156587719,
          "strand": "+",
          "slug": "ttc24"
        },
        {
          "symbol": "NAXE",
          "ensemblId": "ENSG00000163382",
          "biotype": "protein_coding",
          "start": 156591738,
          "end": 156609507,
          "strand": "+",
          "slug": "naxe"
        },
        {
          "symbol": "GPATCH4",
          "ensemblId": "ENSG00000160818",
          "biotype": "protein_coding",
          "start": 156594301,
          "end": 156601496,
          "strand": "-",
          "slug": "gpatch4"
        },
        {
          "symbol": "HAPLN2",
          "ensemblId": "ENSG00000132702",
          "biotype": "protein_coding",
          "start": 156619331,
          "end": 156626590,
          "strand": "+",
          "slug": "hapln2"
        },
        {
          "symbol": "BCAN",
          "ensemblId": "ENSG00000132692",
          "biotype": "protein_coding",
          "start": 156641390,
          "end": 156659532,
          "strand": "+",
          "slug": "bcan"
        },
        {
          "symbol": "NES",
          "ensemblId": "ENSG00000132688",
          "biotype": "protein_coding",
          "start": 156668763,
          "end": 156677415,
          "strand": "-",
          "slug": "nes"
        },
        {
          "symbol": "CRABP2",
          "ensemblId": "ENSG00000143320",
          "biotype": "protein_coding",
          "start": 156699592,
          "end": 156708094,
          "strand": "-",
          "slug": "crabp2"
        },
        {
          "symbol": "ISG20L2",
          "ensemblId": "ENSG00000143319",
          "biotype": "protein_coding",
          "start": 156720651,
          "end": 156728836,
          "strand": "-",
          "slug": "isg20l2"
        },
        {
          "symbol": "METTL25B",
          "ensemblId": "ENSG00000143303",
          "biotype": "protein_coding",
          "start": 156728442,
          "end": 156736960,
          "strand": "+",
          "slug": "mettl25b"
        },
        {
          "symbol": "MRPL24",
          "ensemblId": "ENSG00000143314",
          "biotype": "protein_coding",
          "start": 156737292,
          "end": 156741590,
          "strand": "-",
          "slug": "mrpl24"
        },
        {
          "symbol": "HDGF",
          "ensemblId": "ENSG00000143321",
          "biotype": "protein_coding",
          "start": 156742109,
          "end": 156766925,
          "strand": "-",
          "slug": "hdgf"
        },
        {
          "symbol": "PRCC",
          "ensemblId": "ENSG00000143294",
          "biotype": "protein_coding",
          "start": 156750610,
          "end": 156800818,
          "strand": "+",
          "slug": "prcc"
        },
        {
          "symbol": "SH2D2A",
          "ensemblId": "ENSG00000027869",
          "biotype": "protein_coding",
          "start": 156806235,
          "end": 156817014,
          "strand": "-",
          "slug": "sh2d2a"
        },
        {
          "symbol": "INSRR",
          "ensemblId": "ENSG00000027644",
          "biotype": "protein_coding",
          "start": 156840063,
          "end": 156859122,
          "strand": "-",
          "slug": "insrr"
        },
        {
          "symbol": "PEAR1",
          "ensemblId": "ENSG00000187800",
          "biotype": "protein_coding",
          "start": 156893656,
          "end": 156916432,
          "strand": "+",
          "slug": "pear1"
        },
        {
          "symbol": "LRRC71",
          "ensemblId": "ENSG00000160838",
          "biotype": "protein_coding",
          "start": 156920631,
          "end": 156934915,
          "strand": "+",
          "slug": "lrrc71"
        },
        {
          "symbol": "ARHGEF11",
          "ensemblId": "ENSG00000132694",
          "biotype": "protein_coding",
          "start": 156934840,
          "end": 157046903,
          "strand": "-",
          "slug": "arhgef11"
        },
        {
          "symbol": "ETV3L",
          "ensemblId": "ENSG00000253831",
          "biotype": "protein_coding",
          "start": 157092043,
          "end": 157117877,
          "strand": "-",
          "slug": "etv3l"
        },
        {
          "symbol": "ETV3",
          "ensemblId": "ENSG00000117036",
          "biotype": "protein_coding",
          "start": 157121191,
          "end": 157138952,
          "strand": "-",
          "slug": "etv3"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-sensory-and-autonomic-neuropathies",
        "name": "Neuropatii senzitive și autonome ereditare (inclusiv disautonomia familială)",
        "diseases": [
          {
            "mondoId": "MONDO:0015364",
            "name": "Neuropatie senzitivă și autonomă ereditară",
            "genes": 21,
            "inheritance": null,
            "description": "Un grup de neuropatii, inclusiv disautonomia familială (ELP1), HSAN1 (SPTLC1/SPTLC2), HSAN2 (WNK1, RETREG1) și insensibilitatea congenitală la durere (NTRK1, SCN9A, PRDM12). Majoritatea sunt recesive, în timp ce HSAN1 este dominantă.",
            "management": "Protecție împotriva rănilor, arsurilor și infecțiilor nedetectate, gestionarea simptomelor autonome și testarea de purtător pentru rude (disautonomia familială este inclusă în screeningul de purtător pentru persoanele de origine evreiască ashkenazi).",
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "Natera",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/ro/conditions/hereditary-sensory-and-autonomic-neuropathies"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-autonomic-nervous-system-physiology",
        "name": "Abnormal autonomic nervous system physiology",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-autonomic-nervous-system-physiology"
      },
      {
        "slug": "abnormality-of-the-dentition",
        "name": "Abnormal dentition",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-dentition"
      },
      {
        "slug": "abnormal-emotional-state",
        "name": "Abnormal emotional state",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-emotional-state"
      },
      {
        "slug": "gait-disturbance",
        "name": "Abnormal gait",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/gait-disturbance"
      },
      {
        "slug": "abnormal-lumbar-spine-morphology",
        "name": "Abnormal lumbar spine morphology",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-lumbar-spine-morphology"
      },
      {
        "slug": "abnormality-of-humoral-immunity",
        "name": "Abnormality of humoral immunity",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-humoral-immunity"
      },
      {
        "slug": "abnormality-of-lower-limb-joint",
        "name": "Abnormality of lower limb joint",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-lower-limb-joint"
      },
      {
        "slug": "abnormality-of-peripheral-nerve-conduction",
        "name": "Abnormality of peripheral nerve conduction",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-peripheral-nerve-conduction"
      },
      {
        "slug": "abnormality-of-the-ankle",
        "name": "Abnormality of the ankle",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-ankle"
      },
      {
        "slug": "abnormality-of-the-autonomic-nervous-system",
        "name": "Abnormality of the autonomic nervous system",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormality-of-the-autonomic-nervous-system"
      },
      {
        "slug": "abnormal-gingiva-morphology",
        "name": "Abnormality of the gums",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-gingiva-morphology"
      },
      {
        "slug": "abnormal-hip-bone-morphology",
        "name": "Abnormality of the hip bone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-hip-bone-morphology"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "systems": [],
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abscess",
        "name": "Abscess",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abscess"
      },
      {
        "slug": "aplasia-of-the-sweat-glands",
        "name": "Absent sweat glands",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/aplasia-of-the-sweat-glands"
      },
      {
        "slug": "acral-ulceration",
        "name": "Acral ulceration",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/acral-ulceration"
      },
      {
        "slug": "nail-dysplasia",
        "name": "Atypical nail growth",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/nail-dysplasia"
      },
      {
        "slug": "atypical-scarring-of-skin",
        "name": "Atypical scarring of skin",
        "systems": [
          "abnormality-of-the-integument",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/atypical-scarring-of-skin"
      },
      {
        "slug": "autoamputation-of-digits",
        "name": "Autoamputation of digits",
        "systems": [
          "abnormality-of-limbs"
        ],
        "url": "https://dantelabs.com/traits/autoamputation-of-digits"
      },
      {
        "slug": "osteomyelitis",
        "name": "Bone infection",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/osteomyelitis"
      },
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "emotional-lability",
        "name": "Can't control feelings",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/emotional-lability"
      },
      {
        "slug": "chronic-kidney-disease",
        "name": "Chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/chronic-kidney-disease"
      },
      {
        "slug": "keratitis",
        "name": "Corneal inflammation",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/keratitis"
      },
      {
        "slug": "corneal-scarring",
        "name": "Corneal scarring",
        "systems": [
          "abnormality-of-the-eye",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/corneal-scarring"
      },
      {
        "slug": "corneal-ulceration",
        "name": "Corneal ulceration",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/corneal-ulceration"
      },
      {
        "slug": "avascular-necrosis",
        "name": "Death of bone due to decreased blood supply",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/avascular-necrosis"
      },
      {
        "slug": "decreased-corneal-reflex",
        "name": "Decreased corneal reflex",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-corneal-reflex"
      },
      {
        "slug": "decreased-number-of-small-peripheral-myelinated-nerve-fibers",
        "name": "Decreased number of small peripheral myelinated nerve fibers",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-number-of-small-peripheral-myelinated-nerve-fibers"
      },
      {
        "slug": "distal-sensory-impairment",
        "name": "Decreased sensation in extremities",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/distal-sensory-impairment"
      },
      {
        "slug": "deeply-set-eye",
        "name": "Deeply set eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/deeply-set-eye"
      },
      {
        "slug": "dry-skin",
        "name": "Dry skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dry-skin"
      },
      {
        "slug": "spontaneous-tooth-loss",
        "name": "Early tooth loss",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/spontaneous-tooth-loss"
      },
      {
        "slug": "recurrent-fever",
        "name": "Episodic fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-fever"
      },
      {
        "slug": "hyperhidrosis",
        "name": "Excessive sweating",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hyperhidrosis"
      },
      {
        "slug": "syncope",
        "name": "Fainting spell",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/syncope"
      },
      {
        "slug": "feeding-difficulties",
        "name": "Feeding difficulties",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/feeding-difficulties"
      },
      {
        "slug": "functional-motor-deficit",
        "name": "Functional motor deficit",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/functional-motor-deficit"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "hyperesthesia",
        "name": "Hyperesthesia",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hyperesthesia"
      },
      {
        "slug": "hypothermia",
        "name": "Hypothermia",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hypothermia"
      },
      {
        "slug": "impaired-temperature-sensation",
        "name": "Impaired temperature sensation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/impaired-temperature-sensation"
      },
      {
        "slug": "impulsivity",
        "name": "Impulsivity",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/impulsivity"
      },
      {
        "slug": "alveolar-ridge-overgrowth",
        "name": "Increased size of gum ridge",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/alveolar-ridge-overgrowth"
      },
      {
        "slug": "septic-arthritis",
        "name": "Infected joint",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/septic-arthritis"
      },
      {
        "slug": "fasciitis",
        "name": "Inflammation of the fascia",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fasciitis"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "mild-intellectual-disability",
        "name": "Intellectual disability, mild",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/mild-intellectual-disability"
      },
      {
        "slug": "anhidrosis",
        "name": "Lack of sweating",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anhidrosis"
      },
      {
        "slug": "lichenification",
        "name": "Lichenification",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/lichenification"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "medullary-thyroid-carcinoma",
        "name": "Medullary thyroid carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "url": "https://dantelabs.com/traits/medullary-thyroid-carcinoma"
      },
      {
        "slug": "hyperactivity",
        "name": "More active than typical",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperactivity"
      },
      {
        "slug": "nail-biting",
        "name": "Nail-biting",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nail-biting"
      },
      {
        "slug": "neuropathic-arthropathy",
        "name": "Neuropathic arthropathy",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neuropathic-arthropathy"
      },
      {
        "slug": "opacification-of-the-corneal-stroma",
        "name": "Opacification of the corneal stroma",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/opacification-of-the-corneal-stroma"
      },
      {
        "slug": "orthostatic-hypotension-due-to-autonomic-dysfunction",
        "name": "Orthostatic hypotension due to autonomic dysfunction",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/orthostatic-hypotension-due-to-autonomic-dysfunction"
      },
      {
        "slug": "pain-insensitivity",
        "name": "Pain insensitivity",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/pain-insensitivity"
      },
      {
        "slug": "painless-fractures-due-to-injury",
        "name": "Painless fractures due to injury",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/painless-fractures-due-to-injury"
      },
      {
        "slug": "nail-dystrophy",
        "name": "Poor nail formation",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/nail-dystrophy"
      },
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "poor-wound-healing",
        "name": "Poor wound healing",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/poor-wound-healing"
      },
      {
        "slug": "postural-hypotension-with-compensatory-tachycardia",
        "name": "Postural hypotension with compensatory tachycardia",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/postural-hypotension-with-compensatory-tachycardia"
      },
      {
        "slug": "recurrent-aspiration-pneumonia",
        "name": "Recurrent aspiration pneumonia",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-aspiration-pneumonia"
      },
      {
        "slug": "recurrent-corneal-erosions",
        "name": "Recurrent breakdown of clear protective layer of eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/recurrent-corneal-erosions"
      },
      {
        "slug": "recurrent-staphylococcus-aureus-infection",
        "name": "Recurrent Staphylococcus aureus infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/recurrent-staphylococcus-aureus-infection"
      },
      {
        "slug": "self-mutilation",
        "name": "Self-mutilation",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/self-mutilation"
      },
      {
        "slug": "short-attention-span",
        "name": "Short attention span",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/short-attention-span"
      },
      {
        "slug": "somatic-sensory-dysfunction",
        "name": "Somatic sensory dysfunction",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/somatic-sensory-dysfunction"
      },
      {
        "slug": "sparse-scalp-hair",
        "name": "Sparse scalp hair",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/sparse-scalp-hair"
      },
      {
        "slug": "specific-learning-disability",
        "name": "Specific learning disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/specific-learning-disability"
      },
      {
        "slug": "tongue-pain",
        "name": "Tongue pain",
        "systems": [
          "abnormality-of-head-or-neck",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tongue-pain"
      },
      {
        "slug": "tooth-abscess",
        "name": "Tooth abscess",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tooth-abscess"
      },
      {
        "slug": "trophic-limb-changes",
        "name": "Trophic limb changes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/trophic-limb-changes"
      },
      {
        "slug": "unexplained-fevers",
        "name": "Unexplained fevers",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/unexplained-fevers"
      },
      {
        "slug": "malar-flattening",
        "name": "Zygomatic flattening",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/malar-flattening"
      }
    ],
    "related": [
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/aifm1"
      },
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "name": "atlastin GTPase 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/atl1"
      },
      {
        "slug": "atl3",
        "symbol": "ATL3",
        "name": "atlastin GTPase 3",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/atl3"
      },
      {
        "slug": "clcf1",
        "symbol": "CLCF1",
        "name": "cardiotrophin like cytokine factor 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/clcf1"
      },
      {
        "slug": "crlf1",
        "symbol": "CRLF1",
        "name": "cytokine receptor like factor 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/crlf1"
      },
      {
        "slug": "dnmt1",
        "symbol": "DNMT1",
        "name": "DNA methyltransferase 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/dnmt1"
      },
      {
        "slug": "dst",
        "symbol": "DST",
        "name": "dystonin",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/dst"
      },
      {
        "slug": "elp1",
        "symbol": "ELP1",
        "name": "elongator acetyltransferase complex subunit 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/elp1"
      },
      {
        "slug": "kif1a",
        "symbol": "KIF1A",
        "name": "kinesin family member 1A",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/kif1a"
      },
      {
        "slug": "klhl7",
        "symbol": "KLHL7",
        "name": "kelch like family member 7",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/klhl7"
      },
      {
        "slug": "ngf",
        "symbol": "NGF",
        "name": "nerve growth factor",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/ngf"
      },
      {
        "slug": "prdm12",
        "symbol": "PRDM12",
        "name": "PR/SET domain 12",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/prdm12"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}