{
  "url": "https://dantelabs.com/ro/genes/hgf",
  "gene": {
    "slug": "hgf",
    "symbol": "HGF",
    "name": "hepatocyte growth factor",
    "hgnc": "HGNC:4893",
    "summary": null,
    "location": "7q21.11",
    "locusType": "gene with protein product",
    "aliases": [
      "SF",
      "F-TCF",
      "HGFB",
      "HPTA"
    ],
    "previousSymbols": [
      "DFNB39"
    ],
    "ensemblId": "ENSG00000019991",
    "entrezId": 3082,
    "omim": [
      "142409"
    ],
    "uniprot": [
      "P14210"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "7",
      "start": 81699010,
      "end": 81770047,
      "strand": "-",
      "ensemblTranscript": "ENST00000222390.11",
      "refseqTranscript": "NM_000601.6",
      "ensemblProtein": "ENSP00000222390.5",
      "refseqProtein": "NP_000592.3",
      "exons": [
        {
          "start": 81699010,
          "end": 81702757
        },
        {
          "start": 81705390,
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        },
        {
          "start": 81705647,
          "end": 81705753
        },
        {
          "start": 81706287,
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        },
        {
          "start": 81707290,
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        },
        {
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        },
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        },
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        },
        {
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        },
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        },
        {
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        },
        {
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        },
        {
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        },
        {
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        },
        {
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        {
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        },
        {
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        }
      ],
      "cds": {
        "start": 81702581,
        "end": 81769971
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "7",
      "start": 81328322,
      "end": 81399754,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 81234529,
      "end": 82234528,
      "genes": [
        {
          "symbol": "CACNA2D1",
          "ensemblId": "ENSG00000153956",
          "biotype": "protein_coding",
          "start": 81946444,
          "end": 82444194,
          "strand": "-",
          "slug": "cacna2d1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hearing-loss-and-deafness",
        "name": "Pierderea auzului și surditatea",
        "diseases": [
          {
            "mondoId": "MONDO:0019497",
            "name": "Surditate genetică nesindromică",
            "genes": 97,
            "inheritance": null,
            "description": "Surditate ereditară fără alte manifestări medicale, incluzând formele recesive frecvente cauzate de GJB2, OTOF, SLC26A4, STRC și de multe alte gene, precum și formele dominante, legate de cromozomul X și mitocondriale.",
            "management": "Cunoașterea cauzei genetice poate ghida deciziile privind sprijinul auditiv și implantul cohlear, eligibilitatea pentru studiile de terapie genică (de exemplu, pentru OTOF) și consilierea familială.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Moderate",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/ro/conditions/hearing-loss-and-deafness"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "prelingual-sensorineural-hearing-impairment",
        "name": "Prelingual sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/prelingual-sensorineural-hearing-impairment"
      }
    ],
    "related": [
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "name": "actin gamma 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/actg1"
      },
      {
        "slug": "afg2b",
        "symbol": "AFG2B",
        "name": "AAA ATPase AFG2B",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/afg2b"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/aifm1"
      },
      {
        "slug": "atp11a",
        "symbol": "ATP11A",
        "name": "ATPase phospholipid transporting 11A",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/atp11a"
      },
      {
        "slug": "atp2b2",
        "symbol": "ATP2B2",
        "name": "ATPase plasma membrane Ca2+ transporting 2",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/atp2b2"
      },
      {
        "slug": "cabp2",
        "symbol": "CABP2",
        "name": "calcium binding protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/cabp2"
      },
      {
        "slug": "cd164",
        "symbol": "CD164",
        "name": "CD164 molecule",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/cd164"
      },
      {
        "slug": "cdc14a",
        "symbol": "CDC14A",
        "name": "cell division cycle 14A",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/cdc14a"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "name": "cadherin related 23",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/cdh23"
      },
      {
        "slug": "ceacam16",
        "symbol": "CEACAM16",
        "name": "CEA cell adhesion molecule 16, tectorial membrane component",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/ceacam16"
      },
      {
        "slug": "cib2",
        "symbol": "CIB2",
        "name": "calcium and integrin binding family member 2",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/cib2"
      },
      {
        "slug": "cldn14",
        "symbol": "CLDN14",
        "name": "claudin 14",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/cldn14"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}