{
  "url": "https://dantelabs.com/ro/genes/hbg1",
  "gene": {
    "slug": "hbg1",
    "symbol": "HBG1",
    "name": "hemoglobin subunit gamma 1",
    "hgnc": "HGNC:4831",
    "summary": null,
    "location": "11p15.4",
    "locusType": "gene with protein product",
    "aliases": [
      "HBG-T2"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000213934",
    "entrezId": 3047,
    "omim": [
      "142200"
    ],
    "uniprot": [
      "P69891"
    ],
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      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
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      "end": 5249857,
      "strand": "-",
      "ensemblTranscript": "ENST00000330597.5",
      "refseqTranscript": "NM_000559.3",
      "ensemblProtein": "ENSP00000327431.4",
      "refseqProtein": "NP_000550.2",
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    },
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    },
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        {
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        {
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        {
          "symbol": "OR51G1",
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        {
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        {
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        {
          "symbol": "OR51V1",
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        {
          "symbol": "HBB",
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          "biotype": "protein_coding",
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        {
          "symbol": "HBD",
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        {
          "symbol": "",
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        {
          "symbol": "HBG2",
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          "slug": "hbg2"
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        {
          "symbol": "",
          "ensemblId": "ENSG00000239920",
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        },
        {
          "symbol": "HBE1",
          "ensemblId": "ENSG00000213931",
          "biotype": "protein_coding",
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        {
          "symbol": "OR51B4",
          "ensemblId": "ENSG00000183251",
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          "slug": "or51b4"
        },
        {
          "symbol": "OR51B5",
          "ensemblId": "ENSG00000167355",
          "biotype": "protein_coding",
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          "slug": "or51b5"
        },
        {
          "symbol": "OR51B2",
          "ensemblId": "ENSG00000279012",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "or51b2"
        },
        {
          "symbol": "OR51B6",
          "ensemblId": "ENSG00000176239",
          "biotype": "protein_coding",
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          "slug": "or51b6"
        },
        {
          "symbol": "OR51M1",
          "ensemblId": "ENSG00000184698",
          "biotype": "protein_coding",
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          "slug": "or51m1"
        },
        {
          "symbol": "OR51Q1",
          "ensemblId": "ENSG00000167360",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "or51q1"
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        {
          "symbol": "OR51I1",
          "ensemblId": "ENSG00000167359",
          "biotype": "protein_coding",
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          "slug": "or51i1"
        },
        {
          "symbol": "OR51I2",
          "ensemblId": "ENSG00000187918",
          "biotype": "protein_coding",
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        {
          "symbol": "OR52D1",
          "ensemblId": "ENSG00000181609",
          "biotype": "protein_coding",
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        {
          "symbol": "UBQLN3",
          "ensemblId": "ENSG00000175520",
          "biotype": "protein_coding",
          "start": 5507300,
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          "slug": "ubqln3"
        },
        {
          "symbol": "UBQLNL",
          "ensemblId": "ENSG00000175518",
          "biotype": "protein_coding",
          "start": 5514393,
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          "strand": "-",
          "slug": "ubqlnl"
        },
        {
          "symbol": "OR52H1",
          "ensemblId": "ENSG00000181616",
          "biotype": "protein_coding",
          "start": 5544489,
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          "strand": "-",
          "slug": "or52h1"
        },
        {
          "symbol": "OR52B6",
          "ensemblId": "ENSG00000187747",
          "biotype": "protein_coding",
          "start": 5580877,
          "end": 5581884,
          "strand": "+",
          "slug": "or52b6"
        },
        {
          "symbol": "TRIM6",
          "ensemblId": "ENSG00000121236",
          "biotype": "protein_coding",
          "start": 5596109,
          "end": 5612958,
          "strand": "+",
          "slug": "trim6"
        },
        {
          "symbol": "TRIM6-TRIM34",
          "ensemblId": "ENSG00000258588",
          "biotype": "protein_coding",
          "start": 5596725,
          "end": 5644398,
          "strand": "+",
          "slug": "trim6-trim34"
        },
        {
          "symbol": "TRIM34",
          "ensemblId": "ENSG00000258659",
          "biotype": "protein_coding",
          "start": 5619764,
          "end": 5644398,
          "strand": "+",
          "slug": "trim34"
        },
        {
          "symbol": "TRIM5",
          "ensemblId": "ENSG00000132256",
          "biotype": "protein_coding",
          "start": 5663195,
          "end": 5938619,
          "strand": "-",
          "slug": "trim5"
        },
        {
          "symbol": "TRIM22",
          "ensemblId": "ENSG00000132274",
          "biotype": "protein_coding",
          "start": 5689610,
          "end": 5737089,
          "strand": "+",
          "slug": "trim22"
        },
        {
          "symbol": "OR52P1",
          "ensemblId": "ENSG00000181109",
          "biotype": "protein_coding",
          "start": 5726502,
          "end": 5727464,
          "strand": "+",
          "slug": "or52p1"
        },
        {
          "symbol": "OR56B1",
          "ensemblId": "ENSG00000181023",
          "biotype": "protein_coding",
          "start": 5736448,
          "end": 5738523,
          "strand": "+",
          "slug": "or56b1"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "thalassaemia",
        "name": "Talasemie",
        "diseases": [
          {
            "mondoId": "MONDO:0017145",
            "name": "Beta-talasemie și afecțiuni asociate",
            "genes": 3,
            "inheritance": "autosomal-recessive",
            "description": "Tulburări ale producției de beta-globină, inclusiv beta-talasemia, talasemia hemoglobină E-beta, talasemia delta-beta și hemoglobina Lepore, care variază de la stări de purtător cu anemie ușoară până la boală dependentă de transfuzii.",
            "management": "Starea de purtător este relevantă pentru planificarea familială, iar persoanele afectate pot avea nevoie de transfuzii, terapie de chelare a fierului sau tratamente mai noi.",
            "evidence": {
              "gencc": [
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/ro/conditions/thalassaemia"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-bone-structure",
        "name": "Abnormal bone structure",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-bone-structure"
      },
      {
        "slug": "abnormal-hemoglobin",
        "name": "Abnormal hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-hemoglobin"
      },
      {
        "slug": "asplenia",
        "name": "Absent spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/asplenia"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "hbs-hemoglobin",
        "name": "HbS hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hbs-hemoglobin"
      },
      {
        "slug": "hypochromic-microcytic-anemia",
        "name": "Hypochromic microcytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypochromic-microcytic-anemia"
      },
      {
        "slug": "reticulocytosis",
        "name": "Increased immature red blood cells",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/reticulocytosis"
      },
      {
        "slug": "increased-red-cell-sickling-tendency",
        "name": "Increased red cell sickling tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/increased-red-cell-sickling-tendency"
      },
      {
        "slug": "splenomegaly",
        "name": "Increased spleen size",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/splenomegaly"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "pulmonary-infiltrates",
        "name": "Lung infiltrates",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pulmonary-infiltrates"
      },
      {
        "slug": "microcytic-anemia",
        "name": "Microcytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/microcytic-anemia"
      },
      {
        "slug": "retinopathy",
        "name": "Noninflammatory retina disease",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/retinopathy"
      },
      {
        "slug": "pallor",
        "name": "Paleness",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pallor"
      },
      {
        "slug": "persistence-of-hemoglobin-f",
        "name": "Persistence of hemoglobin F",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/persistence-of-hemoglobin-f"
      },
      {
        "slug": "severe-infection",
        "name": "Severe infection",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/severe-infection"
      },
      {
        "slug": "splenic-infarction",
        "name": "Splenic infarction",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/splenic-infarction"
      }
    ],
    "related": [
      {
        "slug": "hbb",
        "symbol": "HBB",
        "name": "hemoglobin subunit beta",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/hbb"
      },
      {
        "slug": "hbg2",
        "symbol": "HBG2",
        "name": "hemoglobin subunit gamma 2",
        "shared": 1,
        "url": "https://dantelabs.com/ro/genes/hbg2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}