{
  "url": "https://dantelabs.com/ro/genes/grem1",
  "gene": {
    "slug": "grem1",
    "symbol": "GREM1",
    "name": "gremlin 1, DAN family BMP antagonist",
    "hgnc": "HGNC:2001",
    "summary": null,
    "location": "15q13.3",
    "locusType": "gene with protein product",
    "aliases": [
      "DRM",
      "gremlin",
      "DAND2",
      "HMPS"
    ],
    "previousSymbols": [
      "CKTSF1B1",
      "CRAC1"
    ],
    "ensemblId": "ENSG00000166923",
    "entrezId": 26585,
    "omim": [
      "603054"
    ],
    "uniprot": [
      "O60565"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "15",
      "start": 32718004,
      "end": 32745106,
      "strand": "+",
      "ensemblTranscript": "ENST00000651154.1",
      "refseqTranscript": "NM_013372.7",
      "ensemblProtein": "ENSP00000498748.1",
      "refseqProtein": "NP_037504.1",
      "exons": [
        {
          "start": 32718004,
          "end": 32718161
        },
        {
          "start": 32730690,
          "end": 32745106
        }
      ],
      "cds": {
        "start": 32730691,
        "end": 32731245
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "15",
      "start": 33010175,
      "end": 33026870,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 32231555,
      "end": 33231554,
      "genes": [
        {
          "symbol": "GOLGA8K",
          "ensemblId": "ENSG00000249931",
          "biotype": "protein_coding",
          "start": 32389599,
          "end": 32403292,
          "strand": "-",
          "slug": "golga8k"
        },
        {
          "symbol": "GOLGA8O",
          "ensemblId": "ENSG00000206127",
          "biotype": "protein_coding",
          "start": 32441914,
          "end": 32455634,
          "strand": "-",
          "slug": "golga8o"
        },
        {
          "symbol": "GOLGA8N",
          "ensemblId": "ENSG00000232653",
          "biotype": "protein_coding",
          "start": 32593456,
          "end": 32607310,
          "strand": "+",
          "slug": "golga8n"
        },
        {
          "symbol": "ARHGAP11A-SCG5",
          "ensemblId": "ENSG00000288864",
          "biotype": "protein_coding",
          "start": 32613860,
          "end": 32697095,
          "strand": "+",
          "slug": "arhgap11a-scg5"
        },
        {
          "symbol": "ARHGAP11A",
          "ensemblId": "ENSG00000198826",
          "biotype": "protein_coding",
          "start": 32615144,
          "end": 32641334,
          "strand": "+",
          "slug": "arhgap11a"
        },
        {
          "symbol": "SCG5",
          "ensemblId": "ENSG00000166922",
          "biotype": "protein_coding",
          "start": 32641385,
          "end": 32697613,
          "strand": "+",
          "slug": "scg5"
        },
        {
          "symbol": "FMN1",
          "ensemblId": "ENSG00000248905",
          "biotype": "protein_coding",
          "start": 32765544,
          "end": 33194727,
          "strand": "-",
          "slug": "fmn1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "adenocarcinoma-of-the-colon",
        "name": "Adenocarcinoma of the colon",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/adenocarcinoma-of-the-colon"
      },
      {
        "slug": "adenomatous-colonic-polyposis",
        "name": "Adenomatous colonic polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/adenomatous-colonic-polyposis"
      },
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "colon-cancer",
        "name": "Colon cancer",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/colon-cancer"
      },
      {
        "slug": "colorectal-polyposis",
        "name": "Colorectal polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/colorectal-polyposis"
      },
      {
        "slug": "duodenal-adenocarcinoma",
        "name": "Duodenal adenocarcinoma",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/duodenal-adenocarcinoma"
      },
      {
        "slug": "endometrial-carcinoma",
        "name": "Endometrial carcinoma",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/endometrial-carcinoma"
      },
      {
        "slug": "gastrointestinal-desmoid-tumor",
        "name": "Gastrointestinal desmoid tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/gastrointestinal-desmoid-tumor"
      },
      {
        "slug": "neoplasm-of-the-gastrointestinal-tract",
        "name": "Gastrointestinal tract tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-gastrointestinal-tract"
      },
      {
        "slug": "hyperplastic-colonic-polyposis",
        "name": "Hyperplastic colonic polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hyperplastic-colonic-polyposis"
      },
      {
        "slug": "intussusception",
        "name": "Intussusception",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/intussusception"
      },
      {
        "slug": "juvenile-colonic-polyposis",
        "name": "Juvenile colonic polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/juvenile-colonic-polyposis"
      },
      {
        "slug": "prostate-cancer",
        "name": "Prostate cancer",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/prostate-cancer"
      },
      {
        "slug": "hematochezia",
        "name": "Rectal bleeding",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hematochezia"
      },
      {
        "slug": "rectal-polyposis",
        "name": "Rectal polyposis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/rectal-polyposis"
      },
      {
        "slug": "neoplasm-of-the-rectum",
        "name": "Rectal tumor",
        "systems": [
          "abnormality-of-the-digestive-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-rectum"
      },
      {
        "slug": "refractory-anemia",
        "name": "Refractory anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/refractory-anemia"
      },
      {
        "slug": "thyroid-carcinoma",
        "name": "Thyroid carcinoma",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/thyroid-carcinoma"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}